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Development of selective bispecific Wnt mimetics for bone loss and repair

Nature communications, 2021-05, Vol.12 (1), p.3247-3247, Article 3247

2021

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cFLIP regulation of lymphocyte activation and development

Nature Reviews: Immunology, 2006-03, Vol.6 (3), p.196-204

2006

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A WNT mimetic with broad spectrum FZD-specificity decreases fibrosis and improves function in a pulmonary damage model

Respiratory research, 2024-04, Vol.25 (1), p.153-153, Article 153

2024

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Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice

Nature communications, 2023-06, Vol.14 (1), p.2947-15, Article 2947

2023

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Tissue-targeted R-spondin mimetics for liver regeneration

Scientific reports, 2020-08, Vol.10 (1), p.13951-13951, Article 13951

2020

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C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a

Nature, 2007-03, Vol.446 (7132), p.203-207

2007

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Role of a Transductional-Transcriptional Processor Complex Involving MyD88 and IRF-7 in Toll-Like Receptor Signaling

Proceedings of the National Academy of Sciences - PNAS, 2004-10, Vol.101 (43), p.15416-15421

2004

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Targeted protein degradation systems to enhance Wnt signaling

eLife, 2024-06, Vol.13

2024

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IRAK-4 inhibitors for inflammation

Current topics in medicinal chemistry, 2009-05, Vol.9 (8), p.724

2009

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Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia

PloS one, 2015-06, Vol.10 (6), p.e0126924-e0126924

2015

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Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection

The Journal of experimental medicine, 2004-06, Vol.199 (12), p.1651-1658

2004

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Robust Colonic Epithelial Regeneration and Amelioration of Colitis via FZD-Specific Activation of Wnt Signaling

Cellular and molecular gastroenterology and hepatology, 2022-01, Vol.14 (2), p.435-464

2022

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Energy utilization of induced pluripotent stem cell-derived cardiomyocyte in Fabry disease

International journal of cardiology, 2017-04, Vol.232, p.255-263

2017

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Abnormal TNF activity in Timp3 −/− mice leads to chronic hepatic inflammation and failure of liver regeneration

Nature genetics, 2004-09, Vol.36 (9), p.969-977

2004

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PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE[S]

Journal of lipid research, 2014-11, Vol.55 (11), p.2370-2379

2014

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An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

The EMBO journal, 2006-11, Vol.25 (23), p.5549-5559

2006

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Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis

The Journal of experimental medicine, 2005-09, Vol.202 (5), p.589-595

2005

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LPS/TLR4 signal transduction pathway

Cytokine (Philadelphia, Pa.), 2008-05, Vol.42 (2), p.145-151

2008

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IRAK-4 as the central TIR signaling mediator in innate immunity

Trends in Immunology, 2002-10, Vol.23 (10), p.503-506

2002

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Toll-like receptors induce a phagocytic gene program through p38

The Journal of experimental medicine, 2004-01, Vol.199 (1), p.81-90

2004

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Design principles and therapeutic applications of novel synthetic WNT signaling agonists

iScience, 2024-06, Vol.27 (6), p.109938-109938, Article 109938

2024

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Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis

Cell, 2005-05, Vol.121 (4), p.579-591

2005

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Myeloid differentiation factor-88 plays a crucial role in the pathogenesis of coxsackievirus B3-induced myocarditis and influences type I interferon production

Circulation (New York, N.Y.), 2005-10, Vol.112 (15), p.2276-2285

2005

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Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo

Molecular and Cellular Biology, 2005-04, Vol.25 (8), p.3348-3356

2005

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The MAGUK Family Protein CARD11 Is Essential for Lymphocyte Activation

Immunity (Cambridge, Mass.), 2003-06, Vol.18 (6), p.763-775

2003

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Development of selective bispecific Wnt mimetics for bone loss and repair

cFLIP regulation of lymphocyte activation and development

A WNT mimetic with broad spectrum FZD-specificity decreases fibrosis and improves function in a pulmonary damage model

Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice

Tissue-targeted R-spondin mimetics for liver regeneration

C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a

Role of a Transductional-Transcriptional Processor Complex Involving MyD88 and IRF-7 in Toll-Like Receptor Signaling

Targeted protein degradation systems to enhance Wnt signaling

IRAK-4 inhibitors for inflammation

Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia

Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection

Robust Colonic Epithelial Regeneration and Amelioration of Colitis via FZD-Specific Activation of Wnt Signaling

Energy utilization of induced pluripotent stem cell-derived cardiomyocyte in Fabry disease

Abnormal TNF activity in Timp3 −/− mice leads to chronic hepatic inflammation and failure of liver regeneration

PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE[S]

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis

LPS/TLR4 signal transduction pathway

IRAK-4 as the central TIR signaling mediator in innate immunity

Toll-like receptors induce a phagocytic gene program through p38

Design principles and therapeutic applications of novel synthetic WNT signaling agonists

Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis

Myeloid differentiation factor-88 plays a crucial role in the pathogenesis of coxsackievirus B3-induced myocarditis and influences type I interferon production

Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo

The MAGUK Family Protein CARD11 Is Essential for Lymphocyte Activation

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