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Two placebo-controlled crossover studies in healthy subjects to evaluate gastric acid neutralization by an alginate-antacid formulation (Gaviscon Double Action)

Drug development and industrial pharmacy, 2019-03, Vol.45 (3), p.430-438

2019

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Phase I study of Solulin, a novel recombinant soluble human thrombomodulin analogue

Thrombosis and haemostasis, 2011-02, Vol.105 (2), p.302-312

2011

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Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers

Biomedical chromatography, 2011-10, Vol.25 (10), p.1112-1123

2011

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Pharmacokinetics of fingolimod (FTY720) and a combined oral contraceptive coadministered in healthy women: drug-drug interaction study results

International journal of clinical pharmacology and therapeutics, 2012-08, Vol.50 (8), p.540-544

2012

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Serial CSF sampling over a period of 30Â h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile

European journal of clinical pharmacology, 2013-05, Vol.69 (5), p.1083

2013

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Serial CSF sampling over a period of 30 h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile

European journal of clinical pharmacology, 2013-05, Vol.69 (5), p.1083-1090

2013

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Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers: Application of DBS-LC-MS/MS to geno- and phenotyping of P450 enzymes

Biomedical chromatography, 2011-10, Vol.25 (10), p.1112-1123

2011

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NXY-059 Does Not Significantly Interact With Furosemide in Healthy Volunteers

Journal of clinical pharmacology, 2006-12, Vol.46 (12), p.1417-1425

2006

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NXY-059 Does Not Affect Bleeding Time in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, 3-Period Crossover Phase I Study

Journal of clinical pharmacology, 2007-02, Vol.47 (2), p.264-272

2007

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Active Renal Secretion of NXY-059, a Novel Neuroprotectant, Is Mediated via an Organic Acid Transporter

Journal of clinical pharmacology, 2007-07, Vol.47 (7), p.909-914

2007

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Safety, tolerability and pharmacokinetics of escalating doses of NXY-059 in healthy young and elderly subjects

Current medical research and opinion, 2006-09, Vol.22 (9), p.1813-1823

2006

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Polymorphic drug metabolism (CYP2D6) and utilisation of psychotropic drugs in hospitalised psychiatric patients: a retrospective study

European journal of clinical pharmacology, 2003-05, Vol.59 (1), p.57-64

2003

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Plasma Elimination of Milrinone in Rats in Relation to Its Hemodynamic Effects

Journal of pharmaceutical sciences, 1990-03, Vol.79 (3), p.236-239

1990

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Cyclic-AMP mediated drugs: differential or global reduction of eicosanoid synthesis in the isolated rat lung?

Mediators of Inflammation, 1992, Vol.1992 (4), p.255-261

1992

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Comparison of Equilibrium Dialysis, Ultrafiltration, and Gel Permeation Chromatography for the Determination of Free Fractions of Phenobarbital and Phenytoin

Journal of pharmaceutical sciences, 1985-06, Vol.74 (6), p.692-694

1985

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The absolute bioavailability and effect of food on the pharmacokinetics of zolmitriptan in healthy volunteers

British journal of clinical pharmacology, 1998-11, Vol.46 (5), p.433-439

1998

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An optimized methodology for combined phenotyping and genotyping on CYP2D6 and CYP2C19

European journal of clinical pharmacology, 2001-05, Vol.57 (2), p.143-146

2001

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Mephenytoin as a probe for CYP2C19 phenotyping:effect of sample storage, intra‐individual reproducibility and occurrence of adverse events

British journal of clinical pharmacology, 2001-05, Vol.51 (5), p.471-474

2001

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Evaluation of analytical and clinical performance of a dual-probe phenotyping method for CYP2D6 polymorphism and CYP3A4 activity screening

Therapeutic drug monitoring, 2000-08, Vol.22 (4), p.486-496

2000

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The prevalence of CYP2C19 genotypes in a population of healthy Dutch volunteers and apparent gender differences in phenotypes

British journal of clinical pharmacology, 2002-05, Vol.53 (5), p.550P-550P

2002

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Tetrahydrobiopterin induces vasodilatation via enhancement of cGMP level

European journal of pharmacology, 1992-05, Vol.215 (2), p.349-350

1992

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Tetrahydrobiopterin induces vasodilation via enhancement of cGMP level

European journal of pharmacology, 1993, Vol.230 (3), p.387-387

1993

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The effect of pertussis toxin and whole-cell pertussis vaccine on haemodynamics and autonomic responsiveness in the rat depends on route of administration and age

Vaccine, 1998-04, Vol.16 (7), p.666-671

1998

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Comparison of the Antiatherogenic Effects of Isradipine and Ramipril in Cholesterol-Fed Rabbits: I. Effect on Progression of Atherosclerosis and Endothelial Dysfunction

Journal of cardiovascular pharmacology, 1994-03, Vol.23 (3), p.415-423

1994

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Septic shock: no correlation between plasma levels of nitric oxide metabolites and hypotension or lethality

European journal of pharmacology, 1994-08, Vol.270 (4), p.379-382

1994

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Two placebo-controlled crossover studies in healthy subjects to evaluate gastric acid neutralization by an alginate-antacid formulation (Gaviscon Double Action)

Phase I study of Solulin, a novel recombinant soluble human thrombomodulin analogue

Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers

Pharmacokinetics of fingolimod (FTY720) and a combined oral contraceptive coadministered in healthy women: drug-drug interaction study results

Serial CSF sampling over a period of 30Â h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile

Serial CSF sampling over a period of 30 h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile

Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers: Application of DBS-LC-MS/MS to geno- and phenotyping of P450 enzymes

NXY-059 Does Not Significantly Interact With Furosemide in Healthy Volunteers

NXY-059 Does Not Affect Bleeding Time in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, 3-Period Crossover Phase I Study

Active Renal Secretion of NXY-059, a Novel Neuroprotectant, Is Mediated via an Organic Acid Transporter

Safety, tolerability and pharmacokinetics of escalating doses of NXY-059 in healthy young and elderly subjects

Polymorphic drug metabolism (CYP2D6) and utilisation of psychotropic drugs in hospitalised psychiatric patients: a retrospective study

Plasma Elimination of Milrinone in Rats in Relation to Its Hemodynamic Effects

Cyclic-AMP mediated drugs: differential or global reduction of eicosanoid synthesis in the isolated rat lung?

Comparison of Equilibrium Dialysis, Ultrafiltration, and Gel Permeation Chromatography for the Determination of Free Fractions of Phenobarbital and Phenytoin

The absolute bioavailability and effect of food on the pharmacokinetics of zolmitriptan in healthy volunteers

An optimized methodology for combined phenotyping and genotyping on CYP2D6 and CYP2C19

Mephenytoin as a probe for CYP2C19 phenotyping:effect of sample storage, intra‐individual reproducibility and occurrence of adverse events

Evaluation of analytical and clinical performance of a dual-probe phenotyping method for CYP2D6 polymorphism and CYP3A4 activity screening

The prevalence of CYP2C19 genotypes in a population of healthy Dutch volunteers and apparent gender differences in phenotypes

Tetrahydrobiopterin induces vasodilatation via enhancement of cGMP level

Tetrahydrobiopterin induces vasodilation via enhancement of cGMP level

The effect of pertussis toxin and whole-cell pertussis vaccine on haemodynamics and autonomic responsiveness in the rat depends on route of administration and age

Comparison of the Antiatherogenic Effects of Isradipine and Ramipril in Cholesterol-Fed Rabbits: I. Effect on Progression of Atherosclerosis and Endothelial Dysfunction

Septic shock: no correlation between plasma levels of nitric oxide metabolites and hypotension or lethality

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