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Ultrahigh-Throughput and Chromatography-Free Bioanalysis of Polar Analytes with Acoustic Ejection Mass Spectrometry

Analytical chemistry (Washington), 2020-10, Vol.92 (19), p.13525-13531

2020

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Comparative assessment of achiral stationary phases for high throughput analysis in supercritical fluid chromatography

Journal of Chromatography A, 2014-03, Vol.1332, p.73-81

2014

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Microscale purification in support of high-throughput medicinal chemistry

Chemical communications (Cambridge, England), 2021-10, Vol.57 (84), p.1137-114

2021

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Comparison of chromatographic techniques for diastereomer separation of a diverse set of drug-like compounds

Journal of Chromatography A, 2013-01, Vol.1272 (11), p.150-154

2013

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HPLC Biogram Analysis: A Powerful Tool Used for Hit Confirmation in Early Drug Discovery

Journal of biomolecular screening, 2015-06, Vol.20 (5), p.681-687

2015

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An integrated bioanalytical platform for supporting high-throughput serum protein binding screening

Rapid communications in mass spectrometry, 2010-12, Vol.24 (24), p.3593-3601

2010

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Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P-glycoprotein (P-gp) inhibition screen

Rapid communications in mass spectrometry, 2011-05, Vol.25 (9), p.1231-1240

2011

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A high-throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen

Rapid communications in mass spectrometry, 2009-06, Vol.23 (11), p.1579-1591

2009

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Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging

SLAS discovery, 2021-02, Vol.26 (2), p.242-247

2021

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Efficient and library-friendly synthesis of furo- and thieno[2,3- d] pyrimidin-4-amine derivatives by microwave irradiation

Tetrahedron letters, 2010-01, Vol.51 (4), p.629-632

2010

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Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay

Xenobiotica, 2022-07, Vol.52 (7), p.742-750

2022

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Enabling direct and definitive free fraction determination for highly-bound compounds in protein binding assay

Journal of pharmaceutical and biomedical analysis, 2021-02, Vol.194, p.113765-113765, Article 113765

2021

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Acoustic Ejection/Full-Scan Mass Spectrometry Analysis for High-Throughput Compound Quality Control

SLAS technology, 2021-04, Vol.26 (2), p.178-188

2021

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Optimization of microflow LC–MS/MS and its utility in quantitative discovery bioanalysis

Bioanalysis, 2019-06, Vol.11 (11), p.1117-1127

2019

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Addition of Optimized Bovine Serum Albumin Level in a High-Throughput Caco-2 Assay Enabled Accurate Permeability Assessment for Lipophilic Compounds

SLAS discovery, 2019-08, Vol.24 (7), p.738-744

2019

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A high-speed liquid chromatography/tandem mass spectrometry platform using multiplexed multiple-injection chromatography controlled by single software and its application in discovery ADME screening

Rapid communications in mass spectrometry, 2013-04, Vol.27 (7), p.731-737

2013

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Development of an LC–MS/MS method for high throughput quantification of metformin uptake in transporter inhibition assays

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014-09, Vol.967, p.211-218

2014

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Purification of combinatorial libraries

Molecular diversity, 1998-01, Vol.4 (1), p.47-52

Weller, H N

1998

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Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships

Journal of medicinal chemistry, 1993-08, Vol.36 (16), p.2335-2342

1993

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Approach to Improve Compound Recovery in a High-Throughput Caco-2 Permeability Assay Supported by Liquid Chromatography–Tandem Mass Spectrometry

Journal of pharmaceutical sciences, 2012-08, Vol.101 (8), p.2755-2762

2012

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Evaluation of a New Preparative Supercritical Fluid Chromatography System for Compound Library Purification: The TharSFC SFC-MS Prep-100 System

Journal of Laboratory Automation, 2011-06, Vol.16 (3), p.241-249

2011

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Peptidomimetic Synthesis: A Novel, Highly Stereoselective Route to Substituted Freidinger Lactams

Journal of the American Chemical Society, 1994-03, Vol.116 (6), p.2348-2355

1994

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High throughput analysis and purification in support of automated parallel synthesis

Molecular diversity, 1997, Vol.3 (1), p.61-70

1997

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Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays

Bioanalysis, 2012-03, Vol.4 (5), p.581-593

2012

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Convenient and inexpensive procedure for oxidation of secondary alcohols to ketones

Journal of organic chemistry, 1980-05, Vol.45 (10), p.2030-2032

1980

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Ultrahigh-Throughput and Chromatography-Free Bioanalysis of Polar Analytes with Acoustic Ejection Mass Spectrometry

Comparative assessment of achiral stationary phases for high throughput analysis in supercritical fluid chromatography

Microscale purification in support of high-throughput medicinal chemistry

Comparison of chromatographic techniques for diastereomer separation of a diverse set of drug-like compounds

HPLC Biogram Analysis: A Powerful Tool Used for Hit Confirmation in Early Drug Discovery

An integrated bioanalytical platform for supporting high-throughput serum protein binding screening

Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P-glycoprotein (P-gp) inhibition screen

A high-throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen

Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging

Efficient and library-friendly synthesis of furo- and thieno[2,3- d] pyrimidin-4-amine derivatives by microwave irradiation

Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay

Enabling direct and definitive free fraction determination for highly-bound compounds in protein binding assay

Acoustic Ejection/Full-Scan Mass Spectrometry Analysis for High-Throughput Compound Quality Control

Optimization of microflow LC–MS/MS and its utility in quantitative discovery bioanalysis

Addition of Optimized Bovine Serum Albumin Level in a High-Throughput Caco-2 Assay Enabled Accurate Permeability Assessment for Lipophilic Compounds

A high-speed liquid chromatography/tandem mass spectrometry platform using multiplexed multiple-injection chromatography controlled by single software and its application in discovery ADME screening

Development of an LC–MS/MS method for high throughput quantification of metformin uptake in transporter inhibition assays

Purification of combinatorial libraries

Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships

Approach to Improve Compound Recovery in a High-Throughput Caco-2 Permeability Assay Supported by Liquid Chromatography–Tandem Mass Spectrometry

Evaluation of a New Preparative Supercritical Fluid Chromatography System for Compound Library Purification: The TharSFC SFC-MS Prep-100 System

Peptidomimetic Synthesis: A Novel, Highly Stereoselective Route to Substituted Freidinger Lactams

High throughput analysis and purification in support of automated parallel synthesis

Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays

Convenient and inexpensive procedure for oxidation of secondary alcohols to ketones

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