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The physiological interactome of TCR-like antibody therapeutics in human tissues

Nature communications, 2024-04, Vol.15 (1), p.3271-3271, Article 3271

2024

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Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid

Pharmaceutics, 2021-12, Vol.13 (12), p.2105

2021

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A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

Clinical cancer research, 2016-07, Vol.22 (13), p.3286-3297

2016

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Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models

Molecular cancer therapeutics, 2013-10, Vol.12 (10), p.2031-2042

2013

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A Novel Approach for Quantifying the Pharmacological Activity of T-Cell Engagers Utilizing In Vitro Time Course Experiments and Streamlined Data Analysis

The AAPS journal, 2021-12, Vol.24 (1), p.7, Article 7

2021

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Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining In Vitro Experiments with Systems Modeling

Molecular cancer therapeutics, 2021-02, Vol.20 (2), p.357-366

2021

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Abstract 2955: Herceptarg, a novel heterodimeric biparatopic common light chain IgG1 antibody based on trastuzumab and pertuzumab, exerts potent anti-tumoral activity

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2955-2955

2016

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Abstract 3629: Engineering a novel asymmetric head-to-tail 2+1 T-cell bispecific (2+1 TCB) IgG antibody platform with superior T-cell killing compared to 1+1 asymmetric TCBs

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.3629-3629

2017

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Real growth in space manufacturing output substantially exceeds growth in the overall space economy

Acta astronautica, 2024-06, Vol.219, p.236-242

2024

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Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells

Nature communications, 2017-08, Vol.8 (1), p.311-16, Article 311

2017

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Biofuel blending reduces particle emissions from aircraft engines at cruise conditions

Nature (London), 2017-03, Vol.543 (7645), p.411-415

2017

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Aircraft-based observations of isoprene-epoxydiol-derived secondary organic aerosol (IEPOX-SOA) in the tropical upper troposphere over the Amazon region

Atmospheric chemistry and physics, 2018-10, Vol.18 (20), p.14979-15001

2018

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The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs

Oncoimmunology, 2017-02, Vol.6 (2), p.e1273300-e1273300

2017

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Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function

Haematologica (Roma), 2014-06, Vol.99 (6), p.e90

2014

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Sensitivities of Amazonian clouds to aerosols and updraft speed

Atmospheric chemistry and physics, 2017-08, Vol.17 (16), p.10037-10050

2017

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ML-CIRRUS: THE AIRBORNE EXPERIMENT ON NATURAL CIRRUS AND CONTRAIL CIRRUS WITH THE HIGH-ALTITUDE LONG-RANGE RESEARCH AIRCRAFT HALO

Bulletin of the American Meteorological Society, 2017-02, Vol.98 (2), p.271-288

2017

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Porous aerosol in degassing plumes of Mt. Etna and Mt. Stromboli

Atmospheric chemistry and physics, 2016-09, Vol.16 (18), p.11883-11897

2016

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Specificity of JAK-Kinase Inhibition Determines Impact on T-Cell Function

Blood, 2014-12, Vol.124 (21), p.1410-1410

2014

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The physiological interactome of TCR-like antibody therapeutics in human tissues

Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid

A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models

A Novel Approach for Quantifying the Pharmacological Activity of T-Cell Engagers Utilizing In Vitro Time Course Experiments and Streamlined Data Analysis

Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining In Vitro Experiments with Systems Modeling

Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

XGFR, a novel affinity-matured bispecific antibody targeting IGF-1R and EGFR with combined signaling inhibition and enhanced immune activation for the treatment of pancreatic cancer

Abstract 2955: Herceptarg, a novel heterodimeric biparatopic common light chain IgG1 antibody based on trastuzumab and pertuzumab, exerts potent anti-tumoral activity

Abstract 3629: Engineering a novel asymmetric head-to-tail 2+1 T-cell bispecific (2+1 TCB) IgG antibody platform with superior T-cell killing compared to 1+1 asymmetric TCBs

A New Class of T-Cell Bispecific Antibodies for the Treatment of Multiple Myeloma, Binding to B Cell Maturation Antigen and CD3 and Showing Potent, Specific Antitumor Activity in Myeloma Cells and Long Duration of Action in Cynomolgus Monkeys

XGFR, a novel affinity-matured bispecific antibody targeting IGF-1R and EGFR with combined signaling inhibition and enhanced immune activation for the treatment of pancreatic cancer

Real growth in space manufacturing output substantially exceeds growth in the overall space economy

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells

Biofuel blending reduces particle emissions from aircraft engines at cruise conditions

Aircraft-based observations of isoprene-epoxydiol-derived secondary organic aerosol (IEPOX-SOA) in the tropical upper troposphere over the Amazon region

The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs

Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function

Sensitivities of Amazonian clouds to aerosols and updraft speed

Aerosol characteristics and particle production in the upper troposphere over the Amazon Basin

ML-CIRRUS: THE AIRBORNE EXPERIMENT ON NATURAL CIRRUS AND CONTRAIL CIRRUS WITH THE HIGH-ALTITUDE LONG-RANGE RESEARCH AIRCRAFT HALO

Porous aerosol in degassing plumes of Mt. Etna and Mt. Stromboli

Specificity of JAK-Kinase Inhibition Determines Impact on T-Cell Function

Die Krise in Griechenland: Ursprünge, Verlauf, Folgen

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