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Total Synthesis of (+)-Linoxepin by Utilizing the Catellani Reaction

Angewandte Chemie International Edition, 2013-05, Vol.52 (20), p.5305-5308

International ed. in English, 2013

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A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

Nature communications, 2022-10, Vol.13 (1), p.5969-15, Article 5969

2022

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Additive Effects in the Palladium-Catalyzed Carboiodination of Chiral N-Allyl Carboxamides

Angewandte Chemie International Edition, 2014-07, Vol.53 (30), p.7908-7912

International ed. in English, 2014

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Synthesis of the Lycopodium Alkaloid (+)-Lycoflexine

Journal of the American Chemical Society, 2010-10, Vol.132 (41), p.14338-14339

2010

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Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor

Journal of medicinal chemistry, 2022-11, Vol.65 (21), p.14614-14629

2022

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opnMe.com: a digital initiative for sharing tools with the biomedical research community

Nature reviews. Drug discovery, 2022-07, Vol.21 (7), p.475-476

2022

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Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

Nature communications, 2024-03, Vol.15 (1), p.2005-2005, Article 2005

2024

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Application of the Rodriguez–Pattenden Photo-Ring Contraction: Total Synthesis and Configurational Reassignment of 11-Gorgiacerol and 11-Epigorgiacerol

Organic letters, 2012-06, Vol.14 (11), p.2834-2837

2012

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Circulating procoagulant microparticles in cancer patients

Annals of hematology, 2011-04, Vol.90 (4), p.447-453

2011

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Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice

GeroScience, 2024-04, Vol.46 (2), p.2153-2176

2024

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Electrochemical Umpolung C–H Functionalization of Oxindoles

Journal of organic chemistry, 2022-01, Vol.87 (1), p.606-612

2022

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Intermolecular Domino Reaction of Two Aryl Iodides Involving Two CH Functionalizations

Angewandte Chemie International Edition, 2014-05, Vol.53 (20), p.5147-5151

International ed. in English, 2014

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BacPROTACs mediate targeted protein degradation in bacteria

Cell, 2022-06, Vol.185 (13), p.2338-2353.e18

2022

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Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis–Beirut Reaction

Organic process research & development, 2022-08, Vol.26 (8), p.2526-2531

2022

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Synthesis of a 13C-methylene-labeled isoleucine precursor as a useful tool for studying protein side-chain interactions and dynamics

Journal of biomolecular NMR, 2024-03, Vol.78 (1), p.1-8

2024

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Discovery of Novel Spiro[3H‑indole-3,2′-pyrrolidin]-2(1H)‑one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

Journal of medicinal chemistry, 2016-11, Vol.59 (22), p.10147-10162

2016

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Light-Mediated Total Synthesis of 17-Deoxyprovidencin

Angewandte Chemie International Edition, 2014-04, Vol.53 (15), p.3859-3862

International ed. in English, 2014

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13 Cβ‐Valine and 13 Cγ‐Leucine Methine Labeling To Probe Protein Ligand Interaction

Chembiochem : a European journal of chemical biology, 2024-03, Vol.25 (6), p.e202300762-e202300762

2024

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Superparamagnetic Ironoxide Nanoparticles via Ligand Exchange Reactions: Organic 1,2-Diols as Versatile Building Blocks for Surface Engineering

Journal of nanomaterials, 2008-01, Vol.2008 (2008), p.1-10

2008

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Synthesis of Complex Tetracyclic Fused Scaffolds Enabled by (3 + 2) Cycloaddition

Organic letters, 2024-06, Vol.26 (23), p.4873-4876

2024

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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival

Cell, 2023-05, Vol.186 (10), p.2176-2192.e22

2023

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13Cβ‐Valine and 13Cγ‐Leucine Methine Labeling To Probe Protein Ligand Interaction

Chembiochem : a European journal of chemical biology, 2024-03, Vol.25 (6), p.e202300762-n/a

2024

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Application of the Palladium-Catalysed Norbornene-Assisted Catellani Reaction Towards the Total Synthesis of (+)-Linoxepin and Isolinoxepin

European journal of organic chemistry, 2014-07, Vol.2014 (19), p.4053-4069

2014

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Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2–p53 Antagonist Suitable for Intermittent Dose Schedules

Molecular cancer therapeutics, 2024-09, p.OF1-OF14

2024

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Total Synthesis of (+)-Linoxepin by Utilizing the Catellani Reaction

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

Additive Effects in the Palladium-Catalyzed Carboiodination of Chiral N-Allyl Carboxamides

Synthesis of the Lycopodium Alkaloid (+)-Lycoflexine

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor

opnMe.com: a digital initiative for sharing tools with the biomedical research community

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

Application of the Rodriguez–Pattenden Photo-Ring Contraction: Total Synthesis and Configurational Reassignment of 11-Gorgiacerol and 11-Epigorgiacerol

Circulating procoagulant microparticles in cancer patients

Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice

Electrochemical Umpolung C–H Functionalization of Oxindoles

Intermolecular Domino Reaction of Two Aryl Iodides Involving Two CH Functionalizations

BacPROTACs mediate targeted protein degradation in bacteria

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis–Beirut Reaction

Synthesis of a 13C-methylene-labeled isoleucine precursor as a useful tool for studying protein side-chain interactions and dynamics

Discovery of Novel Spiro[3H‑indole-3,2′-pyrrolidin]-2(1H)‑one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

Light-Mediated Total Synthesis of 17-Deoxyprovidencin

13 Cβ‐Valine and 13 Cγ‐Leucine Methine Labeling To Probe Protein Ligand Interaction

Superparamagnetic Ironoxide Nanoparticles via Ligand Exchange Reactions: Organic 1,2-Diols as Versatile Building Blocks for Surface Engineering

Synthesis of Complex Tetracyclic Fused Scaffolds Enabled by (3 + 2) Cycloaddition

Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival

13Cβ‐Valine and 13Cγ‐Leucine Methine Labeling To Probe Protein Ligand Interaction

Application of the Palladium-Catalysed Norbornene-Assisted Catellani Reaction Towards the Total Synthesis of (+)-Linoxepin and Isolinoxepin

Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2–p53 Antagonist Suitable for Intermittent Dose Schedules

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