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Discovery of a novel IL-15 based protein with improved developability and efficacy for cancer immunotherapy

Scientific reports, 2018-05, Vol.8 (1), p.7675-11, Article 7675

2018

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Discovery of a novel RORγ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasis

Scientific reports, 2021-04, Vol.11 (1), p.9132-9132, Article 9132

2021

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SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis

Scientific reports, 2022-05, Vol.12 (1), p.8579-12, Article 8579

2022

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Novel Small Molecule Tyrosine Kinase 2 Pseudokinase Ligands Block Cytokine-Induced TYK2-Mediated Signaling Pathways

Frontiers in immunology, 2022-05, Vol.13, p.884399-884399

2022

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Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

Cancer cell, 2005-07, Vol.8 (1), p.49-59

2005

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Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin’s Lymphoma

ACS medicinal chemistry letters, 2018-02, Vol.9 (2), p.98-102

2018

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A Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer

OncoTargets and therapy, 2021, Vol.14, p.4561-4574

2021

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Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses

Molecular therapy, 2011-03, Vol.19 (3), p.567-575

2011

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Ubiquitin-conjugating enzyme UbcH10 promotes gastric cancer growth and is a potential biomarker for gastric cancer

Oncology reports, 2016-08, Vol.36 (2), p.779-786

2016

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Nucleocytoplasmic Shuttling of Oncoprotein Hdm2 Is Required for Hdm2-Mediated Degradation of p53

Proceedings of the National Academy of Sciences - PNAS, 1999-03, Vol.96 (6), p.3077-3080

1999

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The Mitotic Checkpoint in Cancer Therapy

Cell cycle (Georgetown, Tex.), 2005-11, Vol.4 (11), p.1495-1499

Tao, Weikang

2005

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Discovery of EBI-907: A highly potent and orally active B-Raf V600E inhibitor for the treatment of melanoma and associated cancers

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (3), p.819-823

2016

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Discovery of SHR9352: A Highly Potent G Protein-Biased μ‑Opioid Receptor Agonist

ACS omega, 2017-12, Vol.2 (12), p.9261-9267

2017

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An Inhibitor of the Kinesin Spindle Protein Activates the Intrinsic Apoptotic Pathway Independently of p53 and De Novo Protein Synthesis

Molecular and Cellular Biology, 2007-01, Vol.27 (2), p.689-698

2007

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Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer

European journal of pharmaceutical sciences, 2017-12, Vol.110, p.51-61

2017

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Progress in the development of antiplatelet agents: Focus on the targeted molecular pathway from bench to clinic

Pharmacology & therapeutics (Oxford), 2019-11, Vol.203, p.107393-107393, Article 107393

2019

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Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (10), p.2697-2702

2007

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Pyridyl aminothiazoles as potent Chk1 inhibitors: Optimization of cellular activity

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (7), p.2613-2619

2012

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Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1775-1779

2006

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Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3175-3179

2006

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Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5677-5682

2007

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3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (23), p.6049-6053

2006

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Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.5989-5994

2007

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Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (22), p.5907-5912

2006

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Discovery of a novel IL-15 based protein with improved developability and efficacy for cancer immunotherapy

Discovery of a novel RORγ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasis

SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis

Novel Small Molecule Tyrosine Kinase 2 Pseudokinase Ligands Block Cytokine-Induced TYK2-Mediated Signaling Pathways

Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin’s Lymphoma

A Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer

Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses

Ubiquitin-conjugating enzyme UbcH10 promotes gastric cancer growth and is a potential biomarker for gastric cancer

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Nucleocytoplasmic Shuttling of Oncoprotein Hdm2 Is Required for Hdm2-Mediated Degradation of p53

The Mitotic Checkpoint in Cancer Therapy

Discovery of EBI-907: A highly potent and orally active B-Raf V600E inhibitor for the treatment of melanoma and associated cancers

Discovery of SHR9352: A Highly Potent G Protein-Biased μ‑Opioid Receptor Agonist

An Inhibitor of the Kinesin Spindle Protein Activates the Intrinsic Apoptotic Pathway Independently of p53 and De Novo Protein Synthesis

Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer

Progress in the development of antiplatelet agents: Focus on the targeted molecular pathway from bench to clinic

Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein

Pyridyl aminothiazoles as potent Chk1 inhibitors: Optimization of cellular activity

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP

Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP

3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6

Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors

Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors

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