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Research strategies of small molecules as chemotherapeutics to overcome multiple myeloma resistance

European journal of medicinal chemistry, 2024-05, Vol.271, p.116435-116435, Article 116435

2024

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Design and synthesis 1H-Pyrrolo[2,3-b]pyridine derivatives as FLT3 inhibitors for the treatment of Acute myeloid Leukemia

Bioorganic & medicinal chemistry, 2024-02, Vol.100, p.117631-117631, Article 117631

2024

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Exploring drug repositioning possibilities of kinase inhibitors via molecular simulation

Molecular informatics, 2024-09, Vol.43 (9), p.e202300336-n/a

2024

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Preclinical characterization of danatinib as a novel FLT3 inhibitor with excellent efficacy against resistant acute myeloid leukemia

Biomedicine & pharmacotherapy, 2023-12, Vol.169, p.115905-115905, Article 115905

2023

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Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolo[3,4‐b]pyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia

Drug development research, 2023-04, Vol.84 (2), p.296-311

2023

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Development of Orally Active Thrombin Inhibitors for the Treatment of Thrombotic Disorder Diseases

Molecules, 2015-06, Vol.20 (6), p.11046-11062

2015

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Grinding temperature and power consumption in high speed grinding of Inconel 718 nickel-based superalloy with a vitrified CBN wheel

Precision engineering, 2018-04, Vol.52, p.192-200

2018

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Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics

MedComm - Oncology, 2024-03, Vol.3 (1), p.n/a

2024

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Single diamond grain cutting-edges morphology effect on grinding mechanism of Inconel 718

Precision engineering, 2019-01, Vol.55, p.119-126

2019

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Immobilization of calcium oxide onto chitosan beads as a heterogeneous catalyst for biodiesel production

Polymer international, 2011-06, Vol.60 (6), p.957-962

2011

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Unraveling the Promise of RET Inhibitors in Precision Cancer Therapy by Targeting RET Mutations

Journal of medicinal chemistry, 2024-03, Vol.67 (6), p.4346-4375

2024

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Synthesis and biological evaluation of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine covalent inhibitors as potential agents for the treatment of acute myeloid leukemia

Bioorganic & medicinal chemistry, 2022-09, Vol.70, p.116937-116937, Article 116937

2022

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Scaffold-hopping of Linifanib to Design 6-phenylisoxazolo[3,4-b]pyridin-3-amine Derivatives as FLT3 Inhibitors for Treating Acute Myeloid Leukemia

Letters in drug design & discovery, 2024-08, Vol.21 (10), p.1833-1846

2024

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Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II

Future medicinal chemistry, 2023-01, Vol.15 (1), p.57-71

2023

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Synthesis and Biological Evaluation of 2-Amino-1-phenyl-benzimidazole Derivatives as BACE1 Inhibitors

Letters in drug design & discovery, 2024-06, Vol.21 (7), p.1252-1262

2024

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A SAR Study on a Class of 6-(Trifluoromethyl)-pyridine Derivatives as RORγt Inverse Agonists

Letters in drug design & discovery, 2024-09, Vol.21 (12), p.2359-2373

2024

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Lipase-catalyzed synthesis of butyl propionate in solvent-free system: Optimization by response surface methodology

Journal of the Taiwan Institute of Chemical Engineers, 2014-09, Vol.45 (5), p.2233-2237

2014

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Discovery of SILA-123 as a Highly Potent FLT3 Inhibitor for the Treatment of Acute Myeloid Leukemia with Various FLT3 Mutations

Journal of medicinal chemistry, 2024-09

2024

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Catalyst-free hydrochlorination protocol for terminal arylalkynes with hydrogen chloride

Chinese chemical letters, 2016-11, Vol.27 (11), p.1683-1685

2016

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Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolopyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia

Drug development research, 2023-04, Vol.84 (2), p.296-311

2023

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Annealing Induced Microstructure and Mechanical Property Changes of Impact Resistant Polypropylene Copolymer

Chinese journal of polymer science, 2015-09, Vol.33 (9), p.1211-1211

2015

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Evaluation of neuro-intensive care unit performance in China： predicting outcomes of Simplified Acute Physiology Score II or Glasgow Coma Scale

Chinese medical journal, 2013-03, Vol.126 (6), p.1132-1137

2013

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Metal-organic framework derived CoSe2 nanoparticles anchored on carbon fibers as bifunctional electrocatalysts for efficient overall water splitting

Nano research, 2016-08, Vol.9 (8), p.2234-2243

2016

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Simulation of Chip Formation Behavior during Single Diamond Grains Grinding by CEL Method

Advanced materials research, 2014-09, Vol.1017, p.598-603

2014

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Prognostic value of high-sensitivity cardiac troponin T in patients with en-domyocardial-biopsy proven cardiac amyloidosis

老年心脏病学杂志（英文版）, 2014 (2), p.136-140

Geng QIAN Chen WU Yang ZHANG Yun-Dai CHEN Wei DONG Yi-Hong REN

2014

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Research strategies of small molecules as chemotherapeutics to overcome multiple myeloma resistance

Design and synthesis 1H-Pyrrolo[2,3-b]pyridine derivatives as FLT3 inhibitors for the treatment of Acute myeloid Leukemia

Exploring drug repositioning possibilities of kinase inhibitors via molecular simulation

Preclinical characterization of danatinib as a novel FLT3 inhibitor with excellent efficacy against resistant acute myeloid leukemia

Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolo[3,4‐b]pyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia

Development of Orally Active Thrombin Inhibitors for the Treatment of Thrombotic Disorder Diseases

Grinding temperature and power consumption in high speed grinding of Inconel 718 nickel-based superalloy with a vitrified CBN wheel

Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics

Single diamond grain cutting-edges morphology effect on grinding mechanism of Inconel 718

Immobilization of calcium oxide onto chitosan beads as a heterogeneous catalyst for biodiesel production

Unraveling the Promise of RET Inhibitors in Precision Cancer Therapy by Targeting RET Mutations

Synthesis and biological evaluation of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine covalent inhibitors as potential agents for the treatment of acute myeloid leukemia

Scaffold-hopping of Linifanib to Design 6-phenylisoxazolo[3,4-b]pyridin-3-amine Derivatives as FLT3 Inhibitors for Treating Acute Myeloid Leukemia

Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II

Synthesis and Biological Evaluation of 2-Amino-1-phenyl-benzimidazole Derivatives as BACE1 Inhibitors

A SAR Study on a Class of 6-(Trifluoromethyl)-pyridine Derivatives as RORγt Inverse Agonists

Lipase-catalyzed synthesis of butyl propionate in solvent-free system: Optimization by response surface methodology

Discovery of SILA-123 as a Highly Potent FLT3 Inhibitor for the Treatment of Acute Myeloid Leukemia with Various FLT3 Mutations

Catalyst-free hydrochlorination protocol for terminal arylalkynes with hydrogen chloride

Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolopyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia

Annealing Induced Microstructure and Mechanical Property Changes of Impact Resistant Polypropylene Copolymer

Evaluation of neuro-intensive care unit performance in China： predicting outcomes of Simplified Acute Physiology Score II or Glasgow Coma Scale

Metal-organic framework derived CoSe2 nanoparticles anchored on carbon fibers as bifunctional electrocatalysts for efficient overall water splitting

Simulation of Chip Formation Behavior during Single Diamond Grains Grinding by CEL Method

Prognostic value of high-sensitivity cardiac troponin T in patients with en-domyocardial-biopsy proven cardiac amyloidosis

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