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LC-MS for identifying changes (or lack of it) in ADME across different cohorts

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100565, Article 100565

Wegler, Christine

2024

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Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions

Analytical biochemistry, 2016-09, Vol.509, p.82-88

2016

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Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

Molecular pharmaceutics, 2017-09, Vol.14 (9), p.3142-3151

2017

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Hepatocyte size fractionation allows dissection of human liver zonation

Journal of cellular physiology, 2021-08, Vol.236 (8), p.5885-5894

2021

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A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2909-2913

2017

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Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Biomedicine & pharmacotherapy, 2022-02, Vol.146, p.112501-112501, Article 112501

2022

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Global variability analysis of mRNA and protein concentrations across and within human tissues

NAR genomics and bioinformatics, 2020-03, Vol.2 (1)

2020

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Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial

Clinical and translational science, 2022-01, Vol.15 (1), p.221-233

2022

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Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity

Clinical and translational science, 2022-11, Vol.15 (11), p.2685-2696

2022

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Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis

Computational and structural biotechnology journal, 2023-01, Vol.21, p.4361-4369

2023

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Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Scientific reports, 2017-02, Vol.7 (1), p.43047-43047, Article 43047

2017

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Simple and rapid quantification of cetirizine, venlafaxine, and O-desmethylvenlafaxine in human breast milk, and metformin in human milk and plasma with UHPLC-MS/MS

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2022-08, Vol.1205, p.123340-123340, Article 123340

2022

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Quantitative Proteomics for Translational Pharmacology and Precision Medicine: State of The Art and Future Outlook

Drug metabolism and disposition, 2024-11, Vol.52 (11), p.1208-1216

2024

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Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

Journal of proteome research, 2019-01, Vol.18 (1), p.217-224, Article acs.jproteome.8b00549

2019

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Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.388-396

2021

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Effects of Osteoporosis‐Inducing Drugs on Vitamin D‐Related Gene Transcription and Mineralization in MG‐63 and Saos‐2 Cells

Basic & clinical pharmacology & toxicology, 2016-11, Vol.119 (5), p.436-442

2016

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A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

Drug metabolism and disposition, 2020-01, Vol.48 (1), p.8-17

2020

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Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project

Basic & clinical pharmacology & toxicology, 2024-01, Vol.134 (1), p.153-164

2024

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Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals

Clinical pharmacokinetics, 2024-01, Vol.63 (1), p.109-120

2024

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Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity

Clinical pharmacology and therapeutics, 2022-05, Vol.111 (5), p.1142-1154

2022

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Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

Molecular pharmaceutics, 2021-04, Vol.18 (4), p.1792-1805

2021

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Short‐ and long‐term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity

British journal of clinical pharmacology, 2022-09, Vol.88 (9), p.4121-4133

2022

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Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance

Clinical pharmacokinetics, 2023-05, Vol.62 (5), p.725-735

2023

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Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.239-250

2021

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Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range

European journal of clinical pharmacology, 2022-08, Vol.78 (8), p.1289-1299

2022

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LC-MS for identifying changes (or lack of it) in ADME across different cohorts

Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

Hepatocyte size fractionation allows dissection of human liver zonation

A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Global variability analysis of mRNA and protein concentrations across and within human tissues

Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial

Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity

Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis

Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Simple and rapid quantification of cetirizine, venlafaxine, and O-desmethylvenlafaxine in human breast milk, and metformin in human milk and plasma with UHPLC-MS/MS

Quantitative Proteomics for Translational Pharmacology and Precision Medicine: State of The Art and Future Outlook

Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Effects of Osteoporosis‐Inducing Drugs on Vitamin D‐Related Gene Transcription and Mineralization in MG‐63 and Saos‐2 Cells

A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project

Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals

Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity

Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

Short‐ and long‐term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity

Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance

Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range

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