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Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.7643-7655

2019

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Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses

Journal for immunotherapy of cancer, 2022-07, Vol.10 (7), p.e004122

2022

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Structural insights into the early steps of receptor-transducer signal transfer in archaeal phototaxis

The EMBO journal, 2001-10, Vol.20 (19), p.5312-5319

2001

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Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design

ChemMedChem, 2023-04, Vol.18 (8), p.e202200615-n/a

2023

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Purification of histidine tagged bacteriorhodopsin, pharaonis halorhodopsin and pharaonis sensory rhodopsin II functionally expressed in Escherichia coli

FEBS letters, 1999-01, Vol.442 (2), p.198-202

1999

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Probing the Sensory Rhodopsin II Binding Domain of its Cognate Transducer by Calorimetry and Electrophysiology

Journal of molecular biology, 2003-07, Vol.330 (5), p.1203-1213

2003

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Structural analysis of a HAMP domain: the linker region of the phototransducer in complex with sensory rhodopsin II

The Journal of biological chemistry, 2005-11, Vol.280 (46), p.38767-38775

2005

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Enthalpy−Entropy Compensation in a Photocycle: The K-to-L Transition in Sensory Rhodopsin II from Natronobacterium pharaonis

Journal of the American Chemical Society, 2001-02, Vol.123 (8), p.1766-1767

2001

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Structural Analysis of a HAMP Domain

The Journal of biological chemistry, 2005-11, Vol.280 (46), p.38767-38775

2005

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Thermodynamics of the Early Steps in the Photocycle of Natronobacterium pharaonis Halorhodopsin. Influence of Medium and of Anion Substitution

Photochemistry and photobiology, 2001-09, Vol.74 (3), p.495-503

2001

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Aspartate 75 Mutation in Sensory Rhodopsin II from Natronobacterium pharaonis Does Not Influence the Production of the K-Like Intermediate, but Strongly Affects Its Relaxation Pathway

Biophysical journal, 2000-05, Vol.78 (5), p.2581-2589

2000

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Enthalpy−Entropy Compensation in a Photocycle: The K-to-L Transition in Sensory Rhodopsin II from Natronobacterium p haraonis

Journal of the American Chemical Society, 2001-02, Vol.123 (8), p.1766-1767

2001

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Time-resolved detection of transient movement of helix F in spin-labelled pharaonis sensory rhodopsin II

Journal of molecular biology, 2000-08, Vol.301 (4), p.881-891

2000

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Time-Resolved Absorption and Photothermal Measurements with Recombinant Sensory Rhodopsin II from Natronobacterium pharaonis

Biophysical journal, 1999-12, Vol.77 (6), p.3277-3286

1999

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Thermodynamics of the Early Steps in the Photocycle of Natronobacterium pharaonis Halorhodopsin. Influence of Medium and of Anion Substitution

Photochemistry and photobiology, 2001-09, Vol.74 (3), p.495-503

2001

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Time-resolved detection of transient movement of helix F in spin-labelled pharaonis sensory rhodopsin II 1 1Edited by W. Baumeister

Journal of molecular biology, 2000-08, Vol.301 (4), p.881-891

2000

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Photoreceptors and light signalling

1, 2007

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Archeabacterial phototaxis

Photoreceptors and light signalling, 2003, Vol.3, p.1-39

2003

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Time-resolved absorption and photothermal measurements with recombinant sensory rhodopsin II form Natronobacterium pharaonis

Biophysical journal, 1999-12, Vol.77 (6), p.3277

1999

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Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells

The Journal of biological chemistry, 2019-03, Vol.294 (11), p.4012-4026

2019

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Functional analysis of Hsp70 inhibitors

PloS one, 2013-11, Vol.8 (11), p.e78443-e78443

2013

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Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects

Journal of chemical information and modeling, 2020-11, Vol.60 (11), p.5457-5474

2020

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Structural and Biophysical Characterization of the Syk Activation Switch

Journal of molecular biology, 2013-01, Vol.425 (2), p.309-333

2013

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Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding

The Journal of biological chemistry, 2023-11, Vol.299 (11), p.105328-105328, Article 105328

2023

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Identification of Methionine Aminopeptidase‑2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11119-11134

2019

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Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases

Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses

Structural insights into the early steps of receptor-transducer signal transfer in archaeal phototaxis

Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design

Purification of histidine tagged bacteriorhodopsin, pharaonis halorhodopsin and pharaonis sensory rhodopsin II functionally expressed in Escherichia coli

Probing the Sensory Rhodopsin II Binding Domain of its Cognate Transducer by Calorimetry and Electrophysiology

Structural analysis of a HAMP domain: the linker region of the phototransducer in complex with sensory rhodopsin II

Enthalpy−Entropy Compensation in a Photocycle: The K-to-L Transition in Sensory Rhodopsin II from Natronobacterium pharaonis

Structural Analysis of a HAMP Domain

Thermodynamics of the Early Steps in the Photocycle of Natronobacterium pharaonis Halorhodopsin. Influence of Medium and of Anion Substitution

Aspartate 75 Mutation in Sensory Rhodopsin II from Natronobacterium pharaonis Does Not Influence the Production of the K-Like Intermediate, but Strongly Affects Its Relaxation Pathway

Enthalpy−Entropy Compensation in a Photocycle: The K-to-L Transition in Sensory Rhodopsin II from Natronobacterium p haraonis

Time-resolved detection of transient movement of helix F in spin-labelled pharaonis sensory rhodopsin II

Time-Resolved Absorption and Photothermal Measurements with Recombinant Sensory Rhodopsin II from Natronobacterium pharaonis

Thermodynamics of the Early Steps in the Photocycle of Natronobacterium pharaonis Halorhodopsin. Influence of Medium and of Anion Substitution

Time-resolved detection of transient movement of helix F in spin-labelled pharaonis sensory rhodopsin II 1 1Edited by W. Baumeister

Photoreceptors and light signalling

Archeabacterial phototaxis

Time-resolved absorption and photothermal measurements with recombinant sensory rhodopsin II form Natronobacterium pharaonis

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells

Functional analysis of Hsp70 inhibitors

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects

Structural and Biophysical Characterization of the Syk Activation Switch

Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding

Identification of Methionine Aminopeptidase‑2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer

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