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Aminoacyl-tRNA Synthetases as Valuable Targets for Antimicrobial Drug Discovery

International journal of molecular sciences, 2021-02, Vol.22 (4), p.1750

2021

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Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins

Nucleic acids research, 2019-07, Vol.47 (13), p.7130-7142

2019

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MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes

PloS one, 2014-08, Vol.9 (8), p.e103774-e103774

2014

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Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies

International journal of molecular sciences, 2021-08, Vol.22 (15), p.7793

2021

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Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity

International journal of molecular sciences, 2020-08, Vol.21 (16), p.5859

2020

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The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication

Scientific reports, 2021-03, Vol.11 (1), p.5433-9, Article 5433

2021

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Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides

International journal of molecular sciences, 2022-12, Vol.23 (23), p.15095

2022

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Characterization of Mutants of Human Small Heat Shock Protein HspB1 Carrying Replacements in the N-Terminal Domain and Associated with Hereditary Motor Neuron Diseases

PloS one, 2015-05, Vol.10 (5), p.e0126248-e0126248

2015

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Dissecting the functional role of the N-terminal domain of the human small heat shock protein HSPB6

PloS one, 2014-08, Vol.9 (8), p.e105892

2014

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The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8

International journal of molecular sciences, 2018-07, Vol.19 (7), p.2112

2018

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Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors

Molecules (Basel, Switzerland), 2020-10, Vol.25 (20), p.4751

2020

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Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip

Communications biology, 2022-08, Vol.5 (1), p.883-883, Article 883

2022

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Structural insights into the activity and regulation of human Josephin-2

Journal of structural biology. X, 2019-07, Vol.3 (C), p.100011-100011, Article 100011

2019

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Crag Regulates Epithelial Architecture and Polarized Deposition of Basement Membrane Proteins in Drosophila

Developmental cell, 2008-03, Vol.14 (3), p.354-364

2008

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SUMO fusions and SUMO-specific protease for efficient expression and purification of proteins

Journal of structural and functional genomics, 2004-03, Vol.5 (1-2), p.75-86

2004

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Crystal structures of Lys-63-linked tri- and di-ubiquitin reveal a highly extended chain architecture

Proteins, structure, function, and bioinformatics, 2009-12, Vol.77 (4), p.753-759

2009

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Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator

Structure (London), 2017-02, Vol.25 (2), p.305-316

2017

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Characterization of human small heat shock protein HSPB1 α-crystallin domain localized mutants associated with hereditary motor neuron diseases

Scientific reports, 2018-01, Vol.8 (1), p.688-15, Article 688

2018

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Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors

European journal of medicinal chemistry, 2021-02, Vol.211, p.113021, Article 113021

2021

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Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1

The Journal of biological chemistry, 2017-06, Vol.292 (24), p.9944-9957

2017

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Heptyl α-D-Mannosides Grafted on a β-Cyclodextrin Core To Interfere with Escherichia coli Adhesion: An In Vivo Multivalent Effect

Chemistry : a European journal, 2013-06, Vol.19 (24), p.7847-7855

2013

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Molecular mechanism of two nanobodies that inhibit PAI‐1 activity reveals a modulation at distinct stages of the PAI‐1/plasminogen activator interaction

Journal of thrombosis and haemostasis, 2020-03, Vol.18 (3), p.681-692

2020

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Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase

Bioorganic & medicinal chemistry, 2020-09, Vol.28 (17), p.115645-115645, Article 115645

2020

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Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases

European journal of medicinal chemistry, 2019-07, Vol.173, p.154-166

2019

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Heptyl [alpha]-D-Mannosides Grafted on a [beta]-Cyclodextrin Core To Interfere with Escherichia coli Adhesion: An In Vivo Multivalent Effect

Chemistry : a European journal, 2013-06, Vol.19 (24), p.7847-7855

2013

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Aminoacyl-tRNA Synthetases as Valuable Targets for Antimicrobial Drug Discovery

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins

MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes

Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies

Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity

The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication

Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides

Characterization of Mutants of Human Small Heat Shock Protein HspB1 Carrying Replacements in the N-Terminal Domain and Associated with Hereditary Motor Neuron Diseases

Dissecting the functional role of the N-terminal domain of the human small heat shock protein HSPB6

The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8

Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors

Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip

Structural insights into the activity and regulation of human Josephin-2

Crag Regulates Epithelial Architecture and Polarized Deposition of Basement Membrane Proteins in Drosophila

SUMO fusions and SUMO-specific protease for efficient expression and purification of proteins

Crystal structures of Lys-63-linked tri- and di-ubiquitin reveal a highly extended chain architecture

Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator

Characterization of human small heat shock protein HSPB1 α-crystallin domain localized mutants associated with hereditary motor neuron diseases

Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors

Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1

Heptyl α-D-Mannosides Grafted on a β-Cyclodextrin Core To Interfere with Escherichia coli Adhesion: An In Vivo Multivalent Effect

Molecular mechanism of two nanobodies that inhibit PAI‐1 activity reveals a modulation at distinct stages of the PAI‐1/plasminogen activator interaction

Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase

Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases

Heptyl [alpha]-D-Mannosides Grafted on a [beta]-Cyclodextrin Core To Interfere with Escherichia coli Adhesion: An In Vivo Multivalent Effect

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