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Machine learning methods accurately predict host specificity of coronaviruses based on spike sequences alone

Biochemical and biophysical research communications, 2020-12, Vol.533 (3), p.553-558

2020

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Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance

Chemical communications (Cambridge, England), 2022-10, Vol.58 (84), p.11762-11782

2022

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HIV Protease: Historical Perspective and Current Research

Viruses, 2021-05, Vol.13 (5), p.839

2021

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Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics

PloS one, 2016-12, Vol.11 (12), p.e0168616-e0168616

2016

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Evolution of drug resistance in HIV protease

BMC bioinformatics, 2020-12, Vol.21 (Suppl 18), p.497-497, Article 497

2020

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Enhancing Protein Backbone Binding-A Fruitful Concept for Combating Drug-Resistant HIV

Angewandte Chemie (International ed.), 2012-02, Vol.51 (8), p.1778-1802

International ed. in English, 2012

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Structure-Based Design of Highly Potent HIV‑1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X‑ray Structural Studies

Journal of medicinal chemistry, 2020-05, Vol.63 (9), p.4867-4879

2020

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Discovery of a new flavin N5-adduct in a tyrosine to phenylalanine variant of d-Arginine dehydrogenase

Archives of biochemistry and biophysics, 2022-01, Vol.715 (C), p.109100-109100, Article 109100

2022

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Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for Combating Drug Resistance

Accounts of chemical research, 2008-01, Vol.41 (1), p.78-86

2008

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Potent antiviral HIV-1 protease inhibitor combats highly drug resistant mutant PR20

Biochemical and biophysical research communications, 2019-10, Vol.519 (1), p.61-66

2019

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Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2′ amide-derivatives: Synthesis, biological evaluation and structural studies

Bioorganic & medicinal chemistry letters, 2023-03, Vol.83 (C), p.129168-129168, Article 129168

2023

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Analysis of drug resistance in HIV protease

BMC bioinformatics, 2018-10, Vol.19 (Suppl 11), p.362-362, Article 362

2018

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Design and Synthesis of Potent HIV‑1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X‑ray Structural Studies

Journal of medicinal chemistry, 2018-11, Vol.61 (21), p.9722-9737

2018

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HIV-1 Protease: Structural Perspectives on Drug Resistance

Viruses, 2009-12, Vol.1 (3), p.1110-1136

2009

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Automated prediction of HIV drug resistance from genotype data

BMC bioinformatics, 2016-08, Vol.17 Suppl 8 (Suppl 8), p.278, Article 278

2016

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Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site

Angewandte Chemie (International ed.), 2016-04, Vol.55 (16), p.4924-4927

International ed. in English, 2016

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Room Temperature Neutron Crystallography of Drug Resistant HIV‑1 Protease Uncovers Limitations of X‑ray Structural Analysis at 100 K

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.2018-2025

2017

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Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (22), p.9072-9077

2011

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Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐Ligand X‐ray Structural Studies

ChemMedChem, 2019-11, Vol.14 (21), p.1863-1872

2019

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Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands

ChemMedChem, 2022-05, Vol.17 (9), p.e202200058-n/a

2022

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Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands

Bioorganic & medicinal chemistry letters, 2017-11, Vol.27 (21), p.4925-4931

2017

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Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex

Bioorganic & medicinal chemistry, 2017-10, Vol.25 (19), p.5114-5127

2017

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Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV‑1 Protease Inhibitors: Design, Synthesis, Protein X‑ray Structural Studies, and Biological Evaluation

Journal of medicinal chemistry, 2016-07, Vol.59 (14), p.6826-6837

2016

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Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (21), p.4903-4909

2015

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Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands

European journal of medicinal chemistry, 2018-12, Vol.160 (C), p.171-182

2018

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Machine learning methods accurately predict host specificity of coronaviruses based on spike sequences alone

Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance

HIV Protease: Historical Perspective and Current Research

Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics

Evolution of drug resistance in HIV protease

Enhancing Protein Backbone Binding-A Fruitful Concept for Combating Drug-Resistant HIV

Structure-Based Design of Highly Potent HIV‑1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X‑ray Structural Studies

Discovery of a new flavin N5-adduct in a tyrosine to phenylalanine variant of d-Arginine dehydrogenase

Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for Combating Drug Resistance

Potent antiviral HIV-1 protease inhibitor combats highly drug resistant mutant PR20

Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2′ amide-derivatives: Synthesis, biological evaluation and structural studies

Analysis of drug resistance in HIV protease

Design and Synthesis of Potent HIV‑1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X‑ray Structural Studies

HIV-1 Protease: Structural Perspectives on Drug Resistance

Automated prediction of HIV drug resistance from genotype data

Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site

Room Temperature Neutron Crystallography of Drug Resistant HIV‑1 Protease Uncovers Limitations of X‑ray Structural Analysis at 100 K

Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors

Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐Ligand X‐ray Structural Studies

Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands

Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex

Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV‑1 Protease Inhibitors: Design, Synthesis, Protein X‑ray Structural Studies, and Biological Evaluation

Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands

Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands

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