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Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance

Nature communications, 2022-02, Vol.13 (1), p.770-770, Article 770

2022

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The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

Nature medicine, 2014-02, Vol.20 (2), p.184-192

2014

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Axoplasmic reticulum Ca2+ release causes secondary degeneration of spinal axons

Annals of neurology, 2014-02, Vol.75 (2), p.220-229

2014

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Ligand sensitivity of type-1 inositol 1,4,5-trisphosphate receptor is enhanced by the D2594K mutation

Pflügers Archiv, 2023-05, Vol.475 (5), p.569-581

2023

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Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor

Biochemical journal, 2008-09, Vol.414 (3), p.441-452

2008

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Enhanced Store Overload–Induced Ca2+ Release and Channel Sensitivity to Luminal Ca2+ Activation Are Common Defects of RyR2 Mutations Linked to Ventricular Tachycardia and Sudden Death

Circulation research, 2005-11, Vol.97 (11), p.1173-1181

2005

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Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2

Science (American Association for the Advancement of Science), 2016-10, Vol.354 (6310), p.301-301

2016

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Inherited Dysfunction of Sarcoplasmic Reticulum Ca2+ Handling and Arrhythmogenesis

Circulation research, 2011-04, Vol.108 (7), p.871-883

2011

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Modulation of cardiac ryanodine receptor 2 by calmodulin

Nature (London), 2019-08, Vol.572 (7769), p.347-351

2019

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Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor

PloS one, 2014-04, Vol.9 (4), p.e95615-e95615

2014

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Novel RyR2 Mutation (G3118R) Is Associated With Autosomal Recessive Ventricular Fibrillation and Sudden Death: Clinical, Functional, and Computational Analysis

Journal of the American Heart Association, 2021-03, Vol.10 (6), p.e017128-e017128

2021

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Reduced expression of cardiac ryanodine receptor protects against stress-induced ventricular tachyarrhythmia, but increases the susceptibility to cardiac alternans

Biochemical journal, 2018-01, Vol.475 (1), p.169-183

2018

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Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory

Communications biology, 2022-03, Vol.5 (1), p.183-183, Article 183

2022

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Removal of FKBP12.6 Does Not Alter the Conductance and Activation of the Cardiac Ryanodine Receptor or the Susceptibility to Stress-induced Ventricular Arrhythmias

The Journal of biological chemistry, 2007-11, Vol.282 (48), p.34828-34838

2007

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The central domain of cardiac ryanodine receptor governs channel activation, regulation, and stability

The Journal of biological chemistry, 2020-11, Vol.295 (46), p.15622-15635

2020

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Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (5), p.E859-E868

2017

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RyR2 disease mutations at the C-terminal domain intersubunit interface alter closed-state stability and channel activation

The Journal of biological chemistry, 2021-07, Vol.297 (1), p.100808-100808, Article 100808

2021

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Non-β-Blocking Carvedilol Analog, VK-II-86, Prevents Ouabain-Induced Cardiotoxicity

Circulation Journal, 2018/12/25, Vol.83(1), pp.41-51

2018

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K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association

Biochemical journal, 2007-06, Vol.404 (3), p.431-438

2007

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Red fluorescent genetically encoded Ca2+ indicators for use in mitochondria and endoplasmic reticulum

Biochemical journal, 2014-11, Vol.464 (1), p.13-22

2014

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Abnormal Termination of Ca2+ Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies

Circulation research, 2012-03, Vol.110 (7), p.968-977

2012

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R-carvedilol, a potential new therapy for Alzheimer's disease

Frontiers in pharmacology, 2022-11, Vol.13, p.1062495-1062495

2022

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Corrigendum: R-carvedilol, a potential new therapy for Alzheimer's disease

Frontiers in pharmacology, 2022, Vol.13, p.1125890-1125890

2022

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Three-Dimensional Localization of Serine 2808, a Phosphorylation Site in Cardiac Ryanodine Receptor

The Journal of biological chemistry, 2007-08, Vol.282 (35), p.25929-25939

2007

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Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release

Nature medicine, 2011-07, Vol.17 (8), p.1003-1009

2011

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Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

Axoplasmic reticulum Ca2+ release causes secondary degeneration of spinal axons

Ligand sensitivity of type-1 inositol 1,4,5-trisphosphate receptor is enhanced by the D2594K mutation

Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor

Enhanced Store Overload–Induced Ca2+ Release and Channel Sensitivity to Luminal Ca2+ Activation Are Common Defects of RyR2 Mutations Linked to Ventricular Tachycardia and Sudden Death

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2

Inherited Dysfunction of Sarcoplasmic Reticulum Ca2+ Handling and Arrhythmogenesis

Modulation of cardiac ryanodine receptor 2 by calmodulin

Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor

Novel RyR2 Mutation (G3118R) Is Associated With Autosomal Recessive Ventricular Fibrillation and Sudden Death: Clinical, Functional, and Computational Analysis

Reduced expression of cardiac ryanodine receptor protects against stress-induced ventricular tachyarrhythmia, but increases the susceptibility to cardiac alternans

Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory

Removal of FKBP12.6 Does Not Alter the Conductance and Activation of the Cardiac Ryanodine Receptor or the Susceptibility to Stress-induced Ventricular Arrhythmias

The central domain of cardiac ryanodine receptor governs channel activation, regulation, and stability

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity

RyR2 disease mutations at the C-terminal domain intersubunit interface alter closed-state stability and channel activation

Non-β-Blocking Carvedilol Analog, VK-II-86, Prevents Ouabain-Induced Cardiotoxicity

K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association

Red fluorescent genetically encoded Ca2+ indicators for use in mitochondria and endoplasmic reticulum

Abnormal Termination of Ca2+ Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies

R-carvedilol, a potential new therapy for Alzheimer's disease

Corrigendum: R-carvedilol, a potential new therapy for Alzheimer's disease

Three-Dimensional Localization of Serine 2808, a Phosphorylation Site in Cardiac Ryanodine Receptor

Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release

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