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Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: Current status and future considerations

Drug discovery today. Technologies, 2019-04, Vol.31, p.69-80

2019

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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Angewandte Chemie International Edition, 2021-10, Vol.60 (43), p.23327-23334

International ed. in English, 2021

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Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists

Journal of leukocyte biology, 2008-10, Vol.84 (4), p.1202-1212

2008

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Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia

Cancer discovery, 2022-11, Vol.12 (11), p.2684-2709

2022

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Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3K δ

The Journal of pharmacology and experimental therapeutics, 2017-06, Vol.361 (3), p.429-440

2017

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Optimization of 1,3,4-Benzotriazepine-Based CCK2 Antagonists to Obtain Potent, Orally Active Inhibitors of Gastrin-Mediated Gastric Acid Secretion

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.3101-3112

2007

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Design, Synthesis, and Structure−Activity Relationships of Novel Non-Imidazole Histamine H3 Receptor Antagonists

Journal of medicinal chemistry, 2000-06, Vol.43 (12), p.2362-2370

2000

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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Angewandte Chemie, 2021-10, Vol.133 (43), p.23515-23522

2021

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Optimization of the in Vitro and in Vivo Properties of a Novel Series of 2,4,5-Trisubstituted Imidazoles as Potent Cholecystokinin-2 (CCK2) Antagonists

Journal of medicinal chemistry, 2005-11, Vol.48 (22), p.6803-6812

2005

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Nonpeptide Cholecystokinin-2 Receptor Agonists

Journal of medicinal chemistry, 2001-04, Vol.44 (8), p.1125-1133

2001

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Design, Synthesis, and Structure−Activity Relationships of Novel Non-Imidazole Histamine H 3 Receptor Antagonists

Journal of medicinal chemistry, 2000-06, Vol.43 (12), p.2362-2370

2000

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Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.3101-3112

2007

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Optimization of 1,3,4-Benzotriazepine-Based CCK 2 Antagonists to Obtain Potent, Orally Active Inhibitors of Gastrin-Mediated Gastric Acid Secretion

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.3101-3112

2007

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From histamine to imidazolylalkyl-sulfonamides: The design of a novel series of histamine H 3-receptor antagonists

Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (13), p.1825-1830

1999

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From histamine to imidazolylalkyl-sulfonamides : The design of a novel series of histamine H3-RECEPTOR antagonists

Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (13), p.1825-1830

1999

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Histamine Receptor Assays

Current Protocols in Pharmacology, 2001-11, Vol.14 (1), p.4.17.1-4.17.16

2001

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ChemInform Abstract: From Histamine to Imidazolylalkyl‐sulfonamides: The Design of a Novel Series of Histamine H 3 ‐Receptor Antagonists

ChemInform, 1999-10, Vol.30 (43)

1999

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ChemInform Abstract: From Histamine to Imidazolylalkyl-sulfonamides: The Design of a Novel Series of Histamine H3-Receptor Antagonists

ChemInform, 1999-10, Vol.30 (43), p.no-no

1999

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ChemInform Abstract: Design, Synthesis, and Structure—Activity Relationships of Novel Non‐Imidazole Histamine H 3 Receptor Antagonists

ChemInform, 2000-10, Vol.31 (40)

2000

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ChemInform Abstract: Design, Synthesis, and Structure-Activity Relationships of Novel Non-Imidazole Histamine H3 Receptor Antagonists

ChemInform, 2000-10, Vol.31 (40), p.no-no

2000

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Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE

JNCI : Journal of the National Cancer Institute, 2013-06, Vol.105 (11), p.812-822

2013

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Predicting ultrahigh risk multiple myeloma by molecular profiling: an analysis of newly diagnosed transplant eligible myeloma XI trial patients

Leukemia, 2020-11, Vol.34 (11), p.3091-3096

2020

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A novel mitochondrial DNA variant in MT-ND6: m.14430A>C p.(Trp82Gly) identified in a patient with Leigh syndrome and complex I deficiency

Molecular genetics and metabolism reports, 2024-06, Vol.39, p.101078-101078, Article 101078

2024

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Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial

BMJ (Online), 2021-09, Vol.374, p.n2106

2021

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Factors affecting implementation of interventions for oral health, substance use, smoking and diet for people with severe and multiple disadvantage: a community-based qualitative study in England

BMJ Public Health, 2024-05, Vol.2 (1), p.e000626

2024

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Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: Current status and future considerations

Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists

Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia

Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3K δ

Optimization of 1,3,4-Benzotriazepine-Based CCK2 Antagonists to Obtain Potent, Orally Active Inhibitors of Gastrin-Mediated Gastric Acid Secretion

Design, Synthesis, and Structure−Activity Relationships of Novel Non-Imidazole Histamine H3 Receptor Antagonists

Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Optimization of the in Vitro and in Vivo Properties of a Novel Series of 2,4,5-Trisubstituted Imidazoles as Potent Cholecystokinin-2 (CCK2) Antagonists

Nonpeptide Cholecystokinin-2 Receptor Agonists

Design, Synthesis, and Structure−Activity Relationships of Novel Non-Imidazole Histamine H 3 Receptor Antagonists

Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion

Optimization of 1,3,4-Benzotriazepine-Based CCK 2 Antagonists to Obtain Potent, Orally Active Inhibitors of Gastrin-Mediated Gastric Acid Secretion

From histamine to imidazolylalkyl-sulfonamides: The design of a novel series of histamine H 3-receptor antagonists

From histamine to imidazolylalkyl-sulfonamides : The design of a novel series of histamine H3-RECEPTOR antagonists

Histamine Receptor Assays

ChemInform Abstract: From Histamine to Imidazolylalkyl‐sulfonamides: The Design of a Novel Series of Histamine H 3 ‐Receptor Antagonists

ChemInform Abstract: From Histamine to Imidazolylalkyl-sulfonamides: The Design of a Novel Series of Histamine H3-Receptor Antagonists

ChemInform Abstract: Design, Synthesis, and Structure—Activity Relationships of Novel Non‐Imidazole Histamine H 3 Receptor Antagonists

ChemInform Abstract: Design, Synthesis, and Structure-Activity Relationships of Novel Non-Imidazole Histamine H3 Receptor Antagonists

Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE

Predicting ultrahigh risk multiple myeloma by molecular profiling: an analysis of newly diagnosed transplant eligible myeloma XI trial patients

A novel mitochondrial DNA variant in MT-ND6: m.14430A>C p.(Trp82Gly) identified in a patient with Leigh syndrome and complex I deficiency

Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial

Factors affecting implementation of interventions for oral health, substance use, smoking and diet for people with severe and multiple disadvantage: a community-based qualitative study in England

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