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A novel peptide-based pan-influenza A vaccine: A double blind, randomised clinical trial of immunogenicity and safety

Vaccine, 2015-01, Vol.33 (2), p.396-402

2015

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Vilazodone: A 5‐HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders

CNS neuroscience & therapeutics, 2009-06, Vol.15 (2), p.107-117

2009

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The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction

The international journal of neuropsychopharmacology, 2013-05, Vol.16 (4), p.721-731

2013

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Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex

BMC neuroscience, 2012-04, Vol.13 (1), p.42-42, Article 42

2012

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Characterisation of a wild-type influenza (A/H1N1) virus strain as an experimental challenge agent in humans

Virology journal, 2015-02, Vol.12 (1), p.13-13, Article 13

2015

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Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia

Molecular pharmacology, 2011-05, Vol.79 (5), p.874-885

2011

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Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor

Molecular pharmacology, 2010-07, Vol.78 (1), p.94-104

2010

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Effects of Positive Allosteric Modulators on Single-Cell Oscillatory Ca2+ Signaling Initiated by the Type 5 Metabotropic Glutamate Receptor

Molecular pharmacology, 2009-12, Vol.76 (6), p.1302-1313

2009

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Altered M1 Muscarinic Acetylcholine Receptor (CHRM I)-Gαq/11 Coupling in a Schizophrenia Endophenotype

Neuropsychopharmacology (New York, N.Y.), 2009-08, Vol.34 (9), p.2156-2166

2009

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SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test

Neuropsychopharmacology (New York, N.Y.), 2007-10, Vol.32 (10), p.2163-2172

2007

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In vitro assessment of the agonist properties of the novel 5-HT1A receptor ligand, CUMI-101 (MMP), in rat brain tissue

Nuclear medicine and biology, 2011-02, Vol.38 (2), p.273-277

2011

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In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia

Neuropsychopharmacology (New York, N.Y.), 2008-06, Vol.33 (7), p.1642-1652

2008

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Muscarinic acetylcholine receptors as CNS drug targets

Pharmacology & therapeutics (Oxford), 2008-02, Vol.117 (2), p.232-243

2008

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Pharmacological assessment of m1 muscarinic acetylcholine receptor-gq/11 protein coupling in membranes prepared from postmortem human brain tissue

The Journal of pharmacology and experimental therapeutics, 2008-06, Vol.325 (3), p.869

2008

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New quinoline NK3 receptor antagonists with CNS activity

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.837-840

2009

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The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5434-5438

2010

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muscarinic M₄ receptor is the functionally predominant subtype in rat and mouse striatum as demonstrated using [³⁵S] GTPγS binding

European journal of pharmacology, 2011-02, Vol.652 (1-3), p.1-6

2011

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8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (8), p.2338-2342

2009

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Design and Synthesis of trans-3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1H-3-benzazepine (SB-414796): A Potent and Selective Dopamine D3 Receptor Antagonist

Journal of medicinal chemistry, 2003-11, Vol.46 (23), p.4952-4964

2003

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6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones : Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors

Bioorganic & medicinal chemistry letters, 2008-10, Vol.18 (20), p.5653-5656

2008

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Novel 5-HT1A/1B/1D receptors antagonists with potent 5-HT reuptake inhibitory activity

Bioorganic & medicinal chemistry letters, 2008-10, Vol.18 (20), p.5581-5585

2008

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Serotonergic targets in depression

Current Opinion in Pharmacology, 2002-02, Vol.2 (1), p.18-22

2002

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Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs : in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B

Psychopharmacologia, 2007-05, Vol.192 (1), p.121-133

2007

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In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics

European journal of pharmacology, 2010-02, Vol.627 (1-3), p.106-114

2010

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A novel peptide-based pan-influenza A vaccine: A double blind, randomised clinical trial of immunogenicity and safety

Vilazodone: A 5‐HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders

The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction

Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex

Characterisation of a wild-type influenza (A/H1N1) virus strain as an experimental challenge agent in humans

Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia

Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor

Effects of Positive Allosteric Modulators on Single-Cell Oscillatory Ca2+ Signaling Initiated by the Type 5 Metabotropic Glutamate Receptor

Altered M1 Muscarinic Acetylcholine Receptor (CHRM I)-Gαq/11 Coupling in a Schizophrenia Endophenotype

Design and Synthesis of Novel Tricyclic Benzoxazines as Potent 5-HT1A/B/D Receptor Antagonists Leading to the Discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045)

SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test

In vitro assessment of the agonist properties of the novel 5-HT1A receptor ligand, CUMI-101 (MMP), in rat brain tissue

In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia

Muscarinic acetylcholine receptors as CNS drug targets

Pharmacological assessment of m1 muscarinic acetylcholine receptor-gq/11 protein coupling in membranes prepared from postmortem human brain tissue

New quinoline NK3 receptor antagonists with CNS activity

The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists

muscarinic M₄ receptor is the functionally predominant subtype in rat and mouse striatum as demonstrated using [³⁵S] GTPγS binding

8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II

Design and Synthesis of trans-3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1H-3-benzazepine (SB-414796): A Potent and Selective Dopamine D3 Receptor Antagonist

6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones : Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors

Novel 5-HT1A/1B/1D receptors antagonists with potent 5-HT reuptake inhibitory activity

Serotonergic targets in depression

Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs : in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B

In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics

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