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An Engineered Monovalent Anti–TNF-α Antibody with pH-Sensitive Binding Abrogates Immunogenicity in Mice following a Single Intravenous Dose

The Journal of immunology (1950), 2022-08, Vol.209 (4), p.829-839

2022

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Ultra-potent Antibodies Against Respiratory Syncytial Virus: Effects of Binding Kinetics and Binding Valence on Viral Neutralization

Journal of molecular biology, 2005-07, Vol.350 (1), p.126-144

2005

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Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates

Drug metabolism and disposition, 2007-01, Vol.35 (1), p.86

2007

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Gene Transfer of Cocaine Hydrolase Suppresses Cardiovascular Responses to Cocaine in Rats

Molecular pharmacology, 2005-01, Vol.67 (1), p.204-211

2005

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Optimization of protein therapeutics by directed evolution

Drug Discovery Today, 2003-02, Vol.8 (3), p.118-126

2003

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Monoclonal Antibody Clearance

The Journal of biological chemistry, 2007-01, Vol.282 (3), p.1709-1717

2007

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Screening of phage-expressed antibody libraries by capture lift

Methods in molecular biology (Clifton, N.J.), 2002, Vol.178, p.187

Watkins, Jeffry D

2002

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Stepwise in vitro Affinity Maturation of Vitaxin, an αvβ3-specific Humanized mAb

Proceedings of the National Academy of Sciences - PNAS, 1998-05, Vol.95 (11), p.6037-6042

1998

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Monoclonal Antibody Clearance: IMPACT OF MODULATING THE INTERACTION OF IgG WITH THE NEONATAL Fc RECEPTOR

The Journal of biological chemistry, 2007-01, Vol.282 (3), p.1709-1717

2007

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Expanding the clinical utility of therapeutic proteins: activated protein C variants with improved pharmacological properties

Trends in pharmacological sciences (Regular ed.), 2003-10, Vol.24 (10), p.501-504

2003

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Cloning, isolation and characterization of human tumor in situ monoclonal antibodies

Cancer Immunology, Immunotherapy, 2002-04, Vol.51 (2), p.79-90

2002

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Subcutaneous Administration of AME-133 Demonstrated Significant Dose Dependent B-Cell Depletion in Cynomolgus Monkeys (Macaca fascicularis)

Blood, 2011-11, Vol.118 (21), p.2475-2475

2011

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Novel Protein Agonist of Thrombopoiesis Acts Via a Physiocrine Pathway Distinct From That of Thrombopoietin

Blood, 2011-11, Vol.118 (21), p.2376-2376

2011

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Use of a Peptide Mimotope to Guide the Humanization of MRK-16, an Anti-P-glycoprotein Monoclonal Antibody

The Journal of biological chemistry, 1999-09, Vol.274 (39), p.27371-27378

1999

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Humanized IgG 1 Variants with Differential Binding Properties to the Neonatal Fc Receptor: Relationship to Pharmacokinetics in Mice and Primates

Drug metabolism and disposition, 2007-01, Vol.35 (1), p.86-94

2007

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Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues

Journal of molecular biology, 1999-11, Vol.294 (1), p.151

1999

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Immunolocalization of membrane-associated CTP:phosphocholine cytidylyltransferase in phosphatidylcholine-deficient Chinese hamster ovary cells

The Journal of biological chemistry, 1992-03, Vol.267 (8), p.5686-5692

1992

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AME-133: A Next-Generation Anti-CD20 Engineered for Enhanced Killer Function

Journal of immunotherapy (1997), 2004-11, Vol.27 (6), p.S52

2004

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In Vivo Tumor Growth Inhibition by Monoclonal Antibodies Binding Selectively to Epitopes on Denatured Collagen Present in Tumor Tissue

Journal of immunotherapy (1997), 2004-11, Vol.27 (6), p.S8

2004

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Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues 1 1Edited by J. A. Wells

Journal of molecular biology, 1999-11, Vol.294 (1), p.151-162

1999

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Phosphorylation of CTP:phosphocholine cytidylyltransferase in vivo. Lack of effect of phorbol ester treatment in HeLa cells

The Journal of biological chemistry, 1990-02, Vol.265 (4), p.2190-2197

1990

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In vitro affinity maturation of human IgM antibodies reactive with tumor-associated antigens

Hybridoma and hybridomics, 2001-01, Vol.20 (5-6), p.383-396

2001

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Discovery of Human Antibodies to Cell Surface Antigens by Capture Lift Screening of Phage-Expressed Antibody Libraries

Analytical biochemistry, 1998-02, Vol.256 (2), p.169-177

1998

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Determination of the Relative Affinities of Antibody Fragments Expressed inEscherichia coliby Enzyme-Linked Immunosorbent Assay

Analytical biochemistry, 1997-11, Vol.253 (1), p.37-45

1997

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Stepwise in vitro affinity maturation of Vitaxin, an α v β 3 -specific humanized mAb

Proceedings of the National Academy of Sciences - PNAS, 1998-05, Vol.95 (11), p.6037-6042

1998

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An Engineered Monovalent Anti–TNF-α Antibody with pH-Sensitive Binding Abrogates Immunogenicity in Mice following a Single Intravenous Dose

Ultra-potent Antibodies Against Respiratory Syncytial Virus: Effects of Binding Kinetics and Binding Valence on Viral Neutralization

Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates

Gene Transfer of Cocaine Hydrolase Suppresses Cardiovascular Responses to Cocaine in Rats

Optimization of protein therapeutics by directed evolution

Monoclonal Antibody Clearance

Screening of phage-expressed antibody libraries by capture lift

Stepwise in vitro Affinity Maturation of Vitaxin, an αvβ3-specific Humanized mAb

Monoclonal Antibody Clearance: IMPACT OF MODULATING THE INTERACTION OF IgG WITH THE NEONATAL Fc RECEPTOR

Expanding the clinical utility of therapeutic proteins: activated protein C variants with improved pharmacological properties

Cloning, isolation and characterization of human tumor in situ monoclonal antibodies

Subcutaneous Administration of AME-133 Demonstrated Significant Dose Dependent B-Cell Depletion in Cynomolgus Monkeys (Macaca fascicularis)

Novel Protein Agonist of Thrombopoiesis Acts Via a Physiocrine Pathway Distinct From That of Thrombopoietin

Use of a Peptide Mimotope to Guide the Humanization of MRK-16, an Anti-P-glycoprotein Monoclonal Antibody

Humanized IgG 1 Variants with Differential Binding Properties to the Neonatal Fc Receptor: Relationship to Pharmacokinetics in Mice and Primates

Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues

Immunolocalization of membrane-associated CTP:phosphocholine cytidylyltransferase in phosphatidylcholine-deficient Chinese hamster ovary cells

AME-133: A Next-Generation Anti-CD20 Engineered for Enhanced Killer Function

In Vivo Tumor Growth Inhibition by Monoclonal Antibodies Binding Selectively to Epitopes on Denatured Collagen Present in Tumor Tissue

Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues 1 1Edited by J. A. Wells

Phosphorylation of CTP:phosphocholine cytidylyltransferase in vivo. Lack of effect of phorbol ester treatment in HeLa cells

In vitro affinity maturation of human IgM antibodies reactive with tumor-associated antigens

Discovery of Human Antibodies to Cell Surface Antigens by Capture Lift Screening of Phage-Expressed Antibody Libraries

Determination of the Relative Affinities of Antibody Fragments Expressed inEscherichia coliby Enzyme-Linked Immunosorbent Assay

Stepwise in vitro affinity maturation of Vitaxin, an α v β 3 -specific humanized mAb

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