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ATM-dependent CHK2 Activation Induced by Anticancer Agent, Irofulven

The Journal of biological chemistry, 2004-09, Vol.279 (38), p.39584-39592

2004

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312 Efficacy and Safety of ASP7147, a Bombesin-2 Receptor Antagonist, in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D): Results of a Multicenter, Double-Blind, Placebo-Controlled Trial

Gastroenterology (New York, N.Y. 1943), 2015-04, Vol.148 (4), p.S-69-S-69

2015

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Caspase-mediated apoptosis and caspase-independent cell death induced by irofulven in prostate cancer cells

Molecular cancer therapeutics, 2004-11, Vol.3 (11), p.1385-1396

2004

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Inhibiting Tumor Growth by Targeting Tumor Vasculature with Galectin-1 Antagonist Anginex Conjugated to the Cytotoxic Acylfulvene, 6-Hydroxylpropylacylfulvene

Bioconjugate chemistry, 2010-01, Vol.21 (1), p.20-27

2010

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Ovarian tumor growth regression using a combination of vascular targeting agents anginex or topomimetic 0118 and the chemotherapeutic irofulven

Cancer letters, 2008-07, Vol.265 (2), p.270-280

2008

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Activity of Irofulven against Human Pancreatic Carcinoma Cell Lines In Vitro and In Vivo

Anticancer research, 2004-01, Vol.24 (1), p.59-65

2004

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Cell cycle effects and induction of premitotic apoptosis by irofulven in synchronized cancer cells

Cancer biology & therapy, 2004-11, Vol.3 (11), p.1137-1142

2004

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Marked activity of Irofulven toward human carcinoma cells: Comparison with cisplatin and ecteinascidin

Clinical cancer research, 2003-07, Vol.9 (7), p.2817-2825

2003

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Characterizations of irofulven cytotoxicity in combination with cisplatin and oxaliplatin in human colon, breast, and ovarian cancer cells

Cancer chemotherapy and pharmacology, 2006-04, Vol.57 (4), p.491-499

2006

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Enhanced antitumor activity of irofulven in combination with 5-fluorouracil and cisplatin in human colon and ovarian carcinoma cells

International journal of oncology, 2003-11, Vol.23 (5), p.1347

2003

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Structure−Activity Studies of Antitumor Agent Irofulven (Hydroxymethylacylfulvene) and Analogues

Journal of organic chemistry, 2001-09, Vol.66 (18), p.6158-6163

2001

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Apoptosis induction by the dual-action DNA- and protein-reactive antitumor drug irofulven is largely Bcl-2-independent

Biochemical pharmacology, 2003-02, Vol.65 (4), p.503-513

2003

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Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases

Anticancer research, 2002-03, Vol.22 (2A), p.559

2002

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Antitumor activity of irofulven monotherapy and in combination with mitoxantrone or docetaxel against human prostate cancer models

The Prostate, 2004-04, Vol.59 (1), p.22-32

2004

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Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice

Cancer chemotherapy and pharmacology, 2001-11, Vol.48 (5), p.413-416

2001

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Changes in prostate-specific antigen (PSA) level correlate with growth inhibition of prostate cancer cells treated in vitro with a novel anticancer drug, irofulven

Investigational new drugs, 2001-01, Vol.19 (4), p.283-291

2001

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Marked Activity of Irofulven toward Human Carcinoma Cells

Clinical cancer research, 2003-07, Vol.9 (7), p.2817

2003

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MAC of 1–653 in Beagle Dogs and New Zealand White Rabbits

Anesthesiology (Philadelphia), 1988-07, Vol.69 (1), p.89-91

1988

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Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells

Anticancer research, 2001-05, Vol.21 (3B), p.1789

2001

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MGI 114: augmentation of antitumor activity when combined with topotecan

Journal of pediatric hematology/oncology, 2000-07, Vol.22 (4), p.306-314

2000

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Duration of Opioid Antagonism by Nalmefene and Naloxone in the Dog: An Integrated Pharmacokinetic/Pharmacodynamic Comparison

Journal of pharmaceutical sciences, 1995-09, Vol.84 (9), p.1101-1106

1995

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The Status of Competitive Sport Fishing in North America

Fisheries (Bethesda), 1991-05, Vol.16 (3), p.4-12

1991

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Darss peninsula--a comparison and a contrast with Dungeness

Botanical journal of the Linnean Society, 1989-09, Vol.101 (1), p.178-179

Waters, S.J.P

1989

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Sociological, Economic, and Biological Aspects of Competitive Fishing

Fisheries (Bethesda), 1991-05, Vol.16 (3), p.13-21

1991

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Shingle-based wetlands at Dungeness

Botanical journal of the Linnean Society, 1989-09, Vol.101 (1), p.59-67

1989

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ATM-dependent CHK2 Activation Induced by Anticancer Agent, Irofulven

312 Efficacy and Safety of ASP7147, a Bombesin-2 Receptor Antagonist, in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D): Results of a Multicenter, Double-Blind, Placebo-Controlled Trial

Caspase-mediated apoptosis and caspase-independent cell death induced by irofulven in prostate cancer cells

Inhibiting Tumor Growth by Targeting Tumor Vasculature with Galectin-1 Antagonist Anginex Conjugated to the Cytotoxic Acylfulvene, 6-Hydroxylpropylacylfulvene

Ovarian tumor growth regression using a combination of vascular targeting agents anginex or topomimetic 0118 and the chemotherapeutic irofulven

Activity of Irofulven against Human Pancreatic Carcinoma Cell Lines In Vitro and In Vivo

Cell cycle effects and induction of premitotic apoptosis by irofulven in synchronized cancer cells

Marked activity of Irofulven toward human carcinoma cells: Comparison with cisplatin and ecteinascidin

Characterizations of irofulven cytotoxicity in combination with cisplatin and oxaliplatin in human colon, breast, and ovarian cancer cells

Enhanced antitumor activity of irofulven in combination with 5-fluorouracil and cisplatin in human colon and ovarian carcinoma cells

Structure−Activity Studies of Antitumor Agent Irofulven (Hydroxymethylacylfulvene) and Analogues

Apoptosis induction by the dual-action DNA- and protein-reactive antitumor drug irofulven is largely Bcl-2-independent

Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases

Antitumor activity of irofulven monotherapy and in combination with mitoxantrone or docetaxel against human prostate cancer models

Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice

Changes in prostate-specific antigen (PSA) level correlate with growth inhibition of prostate cancer cells treated in vitro with a novel anticancer drug, irofulven

Marked Activity of Irofulven toward Human Carcinoma Cells

MAC of 1–653 in Beagle Dogs and New Zealand White Rabbits

Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells

MGI 114: augmentation of antitumor activity when combined with topotecan

Duration of Opioid Antagonism by Nalmefene and Naloxone in the Dog: An Integrated Pharmacokinetic/Pharmacodynamic Comparison

The Status of Competitive Sport Fishing in North America

Darss peninsula--a comparison and a contrast with Dungeness

Sociological, Economic, and Biological Aspects of Competitive Fishing

Shingle-based wetlands at Dungeness

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