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CYP51 as drug targets for fungi and protozoan parasites: past, present and future

Parasitology, 2018-12, Vol.145 (14), p.1820-1836

2018

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Sterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasis

Current topics in medicinal chemistry, 2011-08, Vol.11 (16), p.2060-2071

2011

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Unusual properties of the cytochrome P450 superfamily

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2013-02, Vol.368 (1612), p.20120434

2013

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Recent Structural Insights into Cytochrome P450 Function

Trends in pharmacological sciences (Regular ed.), 2016-08, Vol.37 (8), p.625-640

2016

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Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor A3(2)

The Journal of biological chemistry, 2008-03, Vol.283 (13), p.8183-8189

2008

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In Vitro and In Vivo Studies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi

Antimicrobial Agents and Chemotherapy, 2013-09, Vol.57 (9), p.4151-4163

2013

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Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia

Molecular endocrinology (Baltimore, Md.), 2015-09, Vol.29 (9), p.1375-1384

2015

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Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site

The Journal of biological chemistry, 2009-12, Vol.284 (52), p.36711-36719

2009

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The First Virally Encoded Cytochrome P450

Journal of Virology, 2009-08, Vol.83 (16), p.8266-8269

2009

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Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms

Biochemical journal, 2012-04, Vol.443 (1), p.267-277

2012

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Moonlighting cytochrome P450 monooxygenases

IUBMB life, 2011-07, Vol.63 (7), p.473-477

2011

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The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 PikC from Streptomyces venezuelae

The Journal of biological chemistry, 2006-09, Vol.281 (36), p.26289-26297

2006

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ACTH modulation of transcription factors responsible for steroid hydroxylase gene expression in the adrenal cortex

Microscopy research and technique, 2003-06, Vol.61 (3), p.300-307

2003

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CYP51: A Major Drug Target in the Cytochrome P450 Superfamily

Lipids, 2008-12, Vol.43 (12), p.1117-1125

2008

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Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes

The FEBS journal, 2012-05, Vol.279 (9), p.1640-1649

2012

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Cytochromes p450: roles in diseases

The Journal of biological chemistry, 2013-06, Vol.288 (24), p.17091-17098

2013

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Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2

The Journal of biological chemistry, 2005-03, Vol.280 (12), p.11599-11607

2005

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Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design1

Journal of lipid research, 2016-08, Vol.57 (8), p.1552-1563

2016

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The T8590C Polymorphism of CYP4A11 and 20-Hydroxyeicosatetraenoic Acid in Essential Hypertension

Hypertension (Dallas, Tex. 1979), 2008-03, Vol.51 (3), p.767-772

2008

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The role of Ile87 of CYP158A2 in oxidative coupling reaction

Archives of biochemistry and biophysics, 2012-02, Vol.518 (2), p.127-132

2012

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Structural analysis of cytochrome P450 105N1 involved in the biosynthesis of the zincophore, coelibactin

International journal of molecular sciences, 2012-07, Vol.13 (7), p.8500-8513

2012

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Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography

Antimicrobial Agents and Chemotherapy, 2007-11, Vol.51 (11), p.3915-3923

2007

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Association of a CYP4A11 Variant and Blood Pressure in Black Men

Journal of the American Society of Nephrology, 2008-08, Vol.19 (8), p.1606-1612

2008

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Structural basis for conservation in the CYP51 family

Biochimica et biophysica acta, 2011-01, Vol.1814 (1), p.88-93

2011

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Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human Pathogen Trypanosoma cruzi

The Journal of biological chemistry, 2010-08, Vol.285 (33), p.25582-25590

2010

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CYP51 as drug targets for fungi and protozoan parasites: past, present and future

Sterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasis

Unusual properties of the cytochrome P450 superfamily

Recent Structural Insights into Cytochrome P450 Function

Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor A3(2)

In Vitro and In Vivo Studies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi

Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia

Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site

The First Virally Encoded Cytochrome P450

Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms

Moonlighting cytochrome P450 monooxygenases

The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 PikC from Streptomyces venezuelae

ACTH modulation of transcription factors responsible for steroid hydroxylase gene expression in the adrenal cortex

CYP51: A Major Drug Target in the Cytochrome P450 Superfamily

Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes

Cytochromes p450: roles in diseases

Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2

Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design1

The T8590C Polymorphism of CYP4A11 and 20-Hydroxyeicosatetraenoic Acid in Essential Hypertension

The role of Ile87 of CYP158A2 in oxidative coupling reaction

Structural analysis of cytochrome P450 105N1 involved in the biosynthesis of the zincophore, coelibactin

Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography

Association of a CYP4A11 Variant and Blood Pressure in Black Men

Structural basis for conservation in the CYP51 family

Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human Pathogen Trypanosoma cruzi

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