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Discovery of Disubstituted Cyclohexanes as a New Class of CC Chemokine Receptor 2 Antagonists

Journal of medicinal chemistry, 2008-02, Vol.51 (4), p.721-724

2008

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Identification of Peptide Substrates for Human MMP-11 (Stromelysin-3) Using Phage Display

The Journal of biological chemistry, 2003-07, Vol.278 (30), p.27820-27827

2003

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Discovery of a Potent, Selective, and Orally Active Human Epidermal Growth Factor Receptor-2 Sheddase Inhibitor for the Treatment of Cancer

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.603-606

2007

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Protein Design, a Minimalist Approach

Science (American Association for the Advancement of Science), 1989-02, Vol.243 (4891), p.622-628

1989

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Corticotropin-Releasing Hormone Receptor Antagonists: Framework Design and Synthesis Guided by Ligand Conformational Studies

Journal of medicinal chemistry, 1999-03, Vol.42 (5), p.819-832

1999

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Sultam Hydroxamates as Novel Matrix Metalloproteinase Inhibitors

Journal of medicinal chemistry, 2004-06, Vol.47 (12), p.2981-2983

2004

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Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme: Design, Synthesis, and Structure−Activity Relationships

Journal of medicinal chemistry, 2002-11, Vol.45 (23), p.4954-4957

2002

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Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors

Bioorganic & medicinal chemistry, 2008, Vol.18 (1), p.241-246

2008

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Design, Synthesis, and Evaluation of Benzothiadiazepine Hydroxamates as Selective Tumor Necrosis Factor-α Converting Enzyme Inhibitors

Journal of medicinal chemistry, 2003-05, Vol.46 (10), p.1811-1823

2003

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Investigation of glycine α-ketoamide HCV NS3 protease inhibitors: Effect of carboxylic acid isosteres

Bioorganic & medicinal chemistry letters, 2005-08, Vol.15 (15), p.3487-3490

2005

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Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-α converting enzyme

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (12), p.2970-2973

2005

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A molecular modeling analysis of novel non-hydroxamate inhibitors of TACE

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (5), p.1408-1412

2007

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Glycine α-Ketoamides as HCV NS3 Protease Inhibitors

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1111-1114

2003

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A molecular mechanics/grid method for evaluation of ligand-receptor interactions

Journal of computational chemistry, 1995-04, Vol.16 (4), p.454-464

1995

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Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

Journal of medicinal chemistry, 2001-10, Vol.44 (21), p.3351-3354

2001

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Synthetic peptides as models for ion channel proteins

Accounts of chemical research, 1993-04, Vol.26 (4), p.191-197

1993

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Discovery of N-Hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE)

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (12), p.2035-2040

2003

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Potent and selective aggrecanase inhibitors containing cyclic P1 substituents

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1297-1300

2003

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Design and identification of selective HER-2 sheddase inhibitors via P1′ manipulation and unconventional P2′ perturbations to induce a molecular metamorphosis

Bioorganic & medicinal chemistry, 2008, Vol.18 (1), p.159-163

2008

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Potent P1′ biphenylmethyl substituted aggrecanase inhibitors

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (1), p.101-104

2002

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Molecular Characterization of Helix-Loop-Helix Peptides

Science (American Association for the Advancement of Science), 1992-02, Vol.255 (5047), p.979-983

1992

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Macrocyclic Amino Carboxylates as Selective MMP-8 Inhibitors

Journal of medicinal chemistry, 1998-05, Vol.41 (11), p.1749-1751

1998

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Design and Synthesis of a Series of (2R)-N 4-Hydroxy-2-(3-hydroxybenzyl)-N - [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden- 1-yl]butanediamide Derivatives as Potent, Selective, and Orally Bioavailable Aggrecanase Inhibitors

Journal of medicinal chemistry, 2001-10, Vol.44 (21), p.3347-3350

2001

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Making a New Turn In Matrix Metalloprotease Inhibition

Chemistry & biology, 2005-02, Vol.12 (2), p.143-144

Wasserman, Zelda R.

2005

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Structure of the disilene ground state: singlet silylsilylene

Journal of the American Chemical Society, 1979-08, Vol.101 (18), p.5222-5223

1979

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Discovery of Disubstituted Cyclohexanes as a New Class of CC Chemokine Receptor 2 Antagonists

Identification of Peptide Substrates for Human MMP-11 (Stromelysin-3) Using Phage Display

Discovery of a Potent, Selective, and Orally Active Human Epidermal Growth Factor Receptor-2 Sheddase Inhibitor for the Treatment of Cancer

Protein Design, a Minimalist Approach

Corticotropin-Releasing Hormone Receptor Antagonists: Framework Design and Synthesis Guided by Ligand Conformational Studies

Sultam Hydroxamates as Novel Matrix Metalloproteinase Inhibitors

Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme: Design, Synthesis, and Structure−Activity Relationships

Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors

Design, Synthesis, and Evaluation of Benzothiadiazepine Hydroxamates as Selective Tumor Necrosis Factor-α Converting Enzyme Inhibitors

Investigation of glycine α-ketoamide HCV NS3 protease inhibitors: Effect of carboxylic acid isosteres

Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-α converting enzyme

A molecular modeling analysis of novel non-hydroxamate inhibitors of TACE

Glycine α-Ketoamides as HCV NS3 Protease Inhibitors

A molecular mechanics/grid method for evaluation of ligand-receptor interactions

Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

Synthetic peptides as models for ion channel proteins

Discovery of N-Hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE)

Potent and selective aggrecanase inhibitors containing cyclic P1 substituents

Design and identification of selective HER-2 sheddase inhibitors via P1′ manipulation and unconventional P2′ perturbations to induce a molecular metamorphosis

Potent P1′ biphenylmethyl substituted aggrecanase inhibitors

Molecular Characterization of Helix-Loop-Helix Peptides

Macrocyclic Amino Carboxylates as Selective MMP-8 Inhibitors

Design and Synthesis of a Series of (2R)-N 4-Hydroxy-2-(3-hydroxybenzyl)-N - [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden- 1-yl]butanediamide Derivatives as Potent, Selective, and Orally Bioavailable Aggrecanase Inhibitors

Making a New Turn In Matrix Metalloprotease Inhibition

Structure of the disilene ground state: singlet silylsilylene

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