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Chalcone derivatives: synthesis, in vitro and in vivo evaluation of their anti-anxiety, anti-depression and analgesic effects

Heliyon, 2019-03, Vol.5 (3), p.e01376-e01376, Article e01376

2019

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3,3-Dibromoflavanone, a synthetic flavonoid derivative for pain management with antidepressant-like effects and fewer side effects than those of morphine in mice

Chemico-biological interactions, 2024-10, Vol.402, p.111189, Article 111189

2024

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Central nervous system activities of two diterpenes isolated from Aloysia virgata

Phytomedicine (Stuttgart), 2011-03, Vol.18 (5), p.393-401

2011

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In vitro binding affinities of a series of flavonoids for μ-opioid receptors. Antinociceptive effect of the synthetic flavonoid 3,3-dibromoflavanone in mice

Neuropharmacology, 2013-09, Vol.72, p.9-19

2013

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Isovaleramida, principio anticonvulsivo aislado de Valeriana pavonii

Biomédica, 2010, Vol.30 (2), p.245-250

2010

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N-propyl-2,2-diphenyl-2-hydroxyacetamide, a novel α-hydroxyamide with anticonvulsant, anxiolytic and antidepressant-like effects that inhibits voltage-gated sodium channels

European journal of pharmacology, 2018-01, Vol.819, p.270-280

2018

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Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis

Pharmacology, biochemistry and behavior, 2004-02, Vol.77 (2), p.399-404

2004

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Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines

European journal of pharmacology, 2008-02, Vol.580 (3), p.306-313

2008

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Central nervous system depressant action of flavonoid glycosides

European journal of pharmacology, 2006-06, Vol.539 (3), p.168-176

2006

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Anxioselective properties of 6,3′-dinitroflavone, a high-affinity benzodiazepine receptor ligand

European journal of pharmacology, 1996-12, Vol.318 (1), p.23-30

1996

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Chronic Intraperitoneal and Oral Treatments with Hesperidin Induce Central Nervous System Effects in Mice

Phytotherapy research, 2012-02, Vol.26 (2), p.308-312

2012

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Hesperidin induces antinociceptive effect in mice and its aglicone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents

Pharmacology, biochemistry and behavior, 2011-09, Vol.99 (3), p.333-341

2011

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Neuroactive flavonoid glycosides from Tilia petiolaris DC. extracts

Phytotherapy research, 2009-10, Vol.23 (10), p.1453-1457

2009

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Flavonoids as [GABA.sub.A] receptor ligands: the whole story?

Journal of experimental pharmacology, 2012-01, Vol.4, p.9

2012

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6-Bromoflavone, a High Affinity Ligand for the Central Benzodiazepine Receptors Is a Member of a Family of Active Flavonoids

Biochemical and biophysical research communications, 1996-06, Vol.223 (2), p.384-389

1996

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6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS

Pharmacology, biochemistry and behavior, 2003-06, Vol.75 (3), p.537-545

2003

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N, N′-Dicyclohexylsulfamide and N, N′-diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABA A receptor and anxiolytic activity in mice

Biochemical pharmacology, 2012-01, Vol.83 (2), p.253-259

2012

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Synergistic interaction between hesperidin, a natural flavonoid, and diazepam

European journal of pharmacology, 2005-04, Vol.512 (2), p.189-198

2005

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N,N′-Dicyclohexylsulfamide and N,N′-diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABAA receptor and anxiolytic activity in mice

Biochemical pharmacology, 2012, Vol.83 (2), p.253-259

2012

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Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice

Pharmacology, biochemistry and behavior, 2009-04, Vol.92 (2), p.291-296

2009

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N,N&; prime; -Dicyclohexylsulfamide and N,N&; prime; -diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABA sub(A receptor and anxiolytic activity in mice)

Biochemical pharmacology, 2012-01, Vol.83 (2), p.253-259

2012

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Isolation and Identification of 6-Methylapigenin, a Competitive Ligand for the Brain GABAA Receptors, from Valeriana wallichii

Planta medica, 2002-10, Vol.68 (10), p.934-936

2002

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Flavonoids as GABAA receptor ligands: the whole story?

Journal of experimental pharmacology, 2012, Vol.4 (default), p.9-24

2012

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Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii

Planta medica, 2002-10, Vol.68 (10), p.934-936

2002

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Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABAA receptor complex

Bioorganic & medicinal chemistry, 2001, Vol.9 (2), p.323-335

2001

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Chalcone derivatives: synthesis, in vitro and in vivo evaluation of their anti-anxiety, anti-depression and analgesic effects

3,3-Dibromoflavanone, a synthetic flavonoid derivative for pain management with antidepressant-like effects and fewer side effects than those of morphine in mice

Central nervous system activities of two diterpenes isolated from Aloysia virgata

In vitro binding affinities of a series of flavonoids for μ-opioid receptors. Antinociceptive effect of the synthetic flavonoid 3,3-dibromoflavanone in mice

Isovaleramida, principio anticonvulsivo aislado de Valeriana pavonii

N-propyl-2,2-diphenyl-2-hydroxyacetamide, a novel α-hydroxyamide with anticonvulsant, anxiolytic and antidepressant-like effects that inhibits voltage-gated sodium channels

Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis

Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines

Central nervous system depressant action of flavonoid glycosides

Anxioselective properties of 6,3′-dinitroflavone, a high-affinity benzodiazepine receptor ligand

Chronic Intraperitoneal and Oral Treatments with Hesperidin Induce Central Nervous System Effects in Mice

Hesperidin induces antinociceptive effect in mice and its aglicone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents

Neuroactive flavonoid glycosides from Tilia petiolaris DC. extracts

Flavonoids as [GABA.sub.A] receptor ligands: the whole story?

6-Bromoflavone, a High Affinity Ligand for the Central Benzodiazepine Receptors Is a Member of a Family of Active Flavonoids

6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS

N, N′-Dicyclohexylsulfamide and N, N′-diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABA A receptor and anxiolytic activity in mice

Synergistic interaction between hesperidin, a natural flavonoid, and diazepam

N,N′-Dicyclohexylsulfamide and N,N′-diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABAA receptor and anxiolytic activity in mice

Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice

N,N&; prime; -Dicyclohexylsulfamide and N,N&; prime; -diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABA sub(A receptor and anxiolytic activity in mice)

Isolation and Identification of 6-Methylapigenin, a Competitive Ligand for the Brain GABAA Receptors, from Valeriana wallichii

Flavonoids as GABAA receptor ligands: the whole story?

Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii

Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABAA receptor complex

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