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Proposed mechanism for the length dependence of the force developed in maximally activated muscles

Scientific reports, 2019-02, Vol.9 (1), p.1317-1317, Article 1317

2019

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A reverse stroke characterizes the force generation of cardiac myofilaments, leading to an understanding of heart function

Proceedings of the National Academy of Sciences - PNAS, 2021-06, Vol.118 (23), p.1-11

2021

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Mechanism of contraction rhythm homeostasis for hyperthermal sarcomeric oscillations of neonatal cardiomyocytes

Scientific reports, 2020-11, Vol.10 (1), p.20468-20468, Article 20468

2020

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Coordinated force generation of skeletal myosins in myofilaments through motor coupling

Nature communications, 2017-07, Vol.8 (1), p.16036-16036, Article 16036

2017

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Titin-mediated thick filament activation, through a mechanosensing mechanism, introduces sarcomere-length dependencies in mathematical models of rat trabecula and whole ventricle

Scientific reports, 2017-07, Vol.7 (1), p.5546-10, Article 5546

2017

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Including Thermal Fluctuations in Actomyosin Stable States Increases the Predicted Force per Motor and Macroscopic Efficiency in Muscle Modelling

PLoS computational biology, 2016-09, Vol.12 (9), p.e1005083-e1005083

2016

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On random force correction for large time steps in semi-implicitly discretized overdamped Langevin equations

AIMS mathematics, 2024-01, Vol.9 (8), p.20793-20810

2024

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Effect of myofibril passive elastic properties on the mechanical communication between motor proteins on adjacent sarcomeres

Scientific reports, 2019-06, Vol.9 (1), p.9355-17, Article 9355

2019

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Multi-scale simulations of cardiac electrophysiology and mechanics using the University of Tokyo heart simulator

Progress in biophysics and molecular biology, 2012-10, Vol.110 (2-3), p.380-389

2012

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Personalized Perioperative Multi-scale, Multi-physics Heart Simulation of Double Outlet Right Ventricle

Annals of biomedical engineering, 2020-06, Vol.48 (6), p.1740-1750

2020

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Arrhythmic hazard map for a 3D whole‐ventricle model under multiple ion channel block

British journal of pharmacology, 2018-09, Vol.175 (17), p.3435-3452

2018

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Ionic mechanisms of ST segment elevation in electrocardiogram during acute myocardial infarction

The journal of physiological sciences, 2020-07, Vol.70 (1), p.36-36, Article 36

2020

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A thermodynamically consistent monte carlo cross-bridge model with a trapping mechanism reveals the role of stretch activation in heart pumping

Frontiers in physiology, 2022-09, Vol.13, p.855303-855303

2022

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Patient-specific heart simulation can identify non-responders to cardiac resynchronization therapy

Heart and vessels, 2020-08, Vol.35 (8), p.1135-1147

2020

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Using Systolic Local Mechanical Load to Predict Fiber Orientation in Ventricles

Frontiers in physiology, 2020-06, Vol.11

2020

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An application of a patient-specific cardiac simulator for the prediction of outcomes after mitral valve replacement: a pilot study

Journal of artificial organs, 2021-09, Vol.24 (3), p.351-357

2021

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Longitudinal dissociation and transition in thickness of the His‐Purkinje system cause various QRS waveforms of surface ECG under His bundle pacing: A simulation study based on clinical observations

Journal of cardiovascular electrophysiology, 2019-11, Vol.30 (11), p.2582-2590

2019

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A Multiple Step Active Stiffness Integration Scheme to Couple a Stochastic Cross-Bridge Model and Continuum Mechanics for Uses in Both Basic Research and Clinical Applications of Heart Simulation

Frontiers in physiology, 2021-08, Vol.12, p.712816-712816

2021

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A Three-Dimensional Simulation Model of Cardiomyocyte Integrating Excitation-Contraction Coupling and Metabolism

Biophysical journal, 2011-12, Vol.101 (11), p.2601-2610

2011

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Distinct Functional Roles of Cardiac Mitochondrial Subpopulations Revealed by a 3D Simulation Model

Biophysical journal, 2015-06, Vol.108 (11), p.2732-2739

2015

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Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID‐19: A simulation study

Clinical and translational science, 2021-05, Vol.14 (3), p.1092-1100

2021

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Coupling Langevin Dynamics With Continuum Mechanics: Exposing the Role of Sarcomere Stretch Activation Mechanisms to Cardiac Function

Frontiers in physiology, 2018-04, Vol.9, p.333-333

2018

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Tailor-made heart simulation predicts the effect of cardiac resynchronization therapy in a canine model of heart failure

Medical image analysis, 2016-07, Vol.31, p.46-62

2016

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Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart

The Korean journal of physiology & pharmacology, 2019-09, Vol.23 (5), p.295-303

2019

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Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator

Science advances, 2015-05, Vol.1 (4), p.e1400142-e1400142

2015

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Proposed mechanism for the length dependence of the force developed in maximally activated muscles

A reverse stroke characterizes the force generation of cardiac myofilaments, leading to an understanding of heart function

Mechanism of contraction rhythm homeostasis for hyperthermal sarcomeric oscillations of neonatal cardiomyocytes

Coordinated force generation of skeletal myosins in myofilaments through motor coupling

Titin-mediated thick filament activation, through a mechanosensing mechanism, introduces sarcomere-length dependencies in mathematical models of rat trabecula and whole ventricle

Including Thermal Fluctuations in Actomyosin Stable States Increases the Predicted Force per Motor and Macroscopic Efficiency in Muscle Modelling

On random force correction for large time steps in semi-implicitly discretized overdamped Langevin equations

Effect of myofibril passive elastic properties on the mechanical communication between motor proteins on adjacent sarcomeres

Multi-scale simulations of cardiac electrophysiology and mechanics using the University of Tokyo heart simulator

Personalized Perioperative Multi-scale, Multi-physics Heart Simulation of Double Outlet Right Ventricle

Arrhythmic hazard map for a 3D whole‐ventricle model under multiple ion channel block

Ionic mechanisms of ST segment elevation in electrocardiogram during acute myocardial infarction

A thermodynamically consistent monte carlo cross-bridge model with a trapping mechanism reveals the role of stretch activation in heart pumping

Patient-specific heart simulation can identify non-responders to cardiac resynchronization therapy

Using Systolic Local Mechanical Load to Predict Fiber Orientation in Ventricles

An application of a patient-specific cardiac simulator for the prediction of outcomes after mitral valve replacement: a pilot study

Longitudinal dissociation and transition in thickness of the His‐Purkinje system cause various QRS waveforms of surface ECG under His bundle pacing: A simulation study based on clinical observations

A Multiple Step Active Stiffness Integration Scheme to Couple a Stochastic Cross-Bridge Model and Continuum Mechanics for Uses in Both Basic Research and Clinical Applications of Heart Simulation

A Three-Dimensional Simulation Model of Cardiomyocyte Integrating Excitation-Contraction Coupling and Metabolism

Distinct Functional Roles of Cardiac Mitochondrial Subpopulations Revealed by a 3D Simulation Model

Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID‐19: A simulation study

Coupling Langevin Dynamics With Continuum Mechanics: Exposing the Role of Sarcomere Stretch Activation Mechanisms to Cardiac Function

Tailor-made heart simulation predicts the effect of cardiac resynchronization therapy in a canine model of heart failure

Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart

Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator

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