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Development of the Renal Glucose Reabsorption Inhibitors: A New Mechanism for the Pharmacotherapy of Diabetes Mellitus Type 2

Journal of medicinal chemistry, 2009-04, Vol.52 (7), p.1785-1794

Washburn, William N

2009

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Differentiating sodium-glucose co-transporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus

Expert opinion on investigational drugs, 2013-04, Vol.22 (4), p.463-486

2013

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Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats

Diabetes (New York, N.Y.), 2008-06, Vol.57 (6), p.1723-1729

2008

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A Practical Stereoselective Synthesis and Novel Cocrystallizations of an Amphiphatic SGLT-2 Inhibitor

Organic process research & development, 2012-04, Vol.16 (4), p.577-585

2012

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Exploring monocyclic core: Discovery of pyrrol-2-one derivatives as a new series of potent MCHR1 antagonists with in vivo efficacy

European journal of medicinal chemistry, 2024-10, Vol.276, p.116686, Article 116686

2024

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Sodium glucose co-transporter 2 (SGLT2) inhibitors: novel antidiabetic agents

Expert opinion on therapeutic patents, 2012-05, Vol.22 (5), p.483-494

Washburn, William N

2012

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Chemical analysis of cacao residues in archaeological ceramics from North America: considerations of contamination, sample size and systematic controls

Journal of archaeological science, 2014-10, Vol.50, p.191-207

2014

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The prehistoric drug trade: widespread consumption of cacao in Ancestral Pueblo and Hohokam communities in the American Southwest

Journal of archaeological science, 2011-07, Vol.38 (7), p.1634-1640

2011

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Cacao consumption during the 8th century at Alkali Ridge, southeastern Utah

Journal of archaeological science, 2013-04, Vol.40 (4), p.2007-2013

2013

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Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2

Bioorganic & medicinal chemistry letters, 2008-09, Vol.18 (17), p.4770-4773

2008

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Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup

Bioorganic & medicinal chemistry letters, 2015-07, Vol.25 (14), p.2793-2799

2015

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Discovery of pyrazine carboxamide CB1 antagonists: The introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3978-3982

2007

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C-Arylglucoside synthesis: triisopropylsilane as a selective reagent for the reduction of an anomeric C-phenyl ketal

Tetrahedron: asymmetry, 2003-10, Vol.14 (20), p.3243-3247

2003

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Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-α-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (15), p.4131-4134

2007

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Dapagliflozin, A Selective SGLT2 Inhibitor for Treatment of Diabetes

Successful Drug Discovery, 2015, p.87-112

2015

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Synthesis and reactions of bicyclo[3.1.0]hexatrienes

Journal of the American Chemical Society, 1978-08, Vol.100 (18), p.5863-5874

1978

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Novel general approach for the assay and inhibition of hydrolytic enzymes utilizing suicide-inhibitory bifunctionally linked substrates (SIBLINKS): exemplified by a phospholipase A2 assay

Journal of the American Chemical Society, 1990-02, Vol.112 (5), p.2040-2041

1990

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Suicide-inhibitory bifunctionally linked substrates (SIBLINKS) as phospholipase A2 inhibitors

Journal of the American Chemical Society, 1990-02, Vol.112 (5), p.2042-2043

1990

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Role of the symbiotic algae of Plexaura homomalla in prostaglandin biosynthesis

Journal of the American Chemical Society, 1974-02, Vol.96 (3), p.934-935

1974

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Bishomoaromatic stabilization of bicyclic anions

Journal of organic chemistry, 1983-11, Vol.48 (23), p.4287-4289

Washburn, William N

1983

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Intramolecular nucleophilic catalysis during alkaline hydrolysis of nonenolizable .beta.-keto esters

Journal of the American Chemical Society, 1986-09, Vol.108 (19), p.5962-5964

1986

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Asymmetric induction arising from .sigma./.pi. interactions

Journal of the American Chemical Society, 1984-08, Vol.106 (16), p.4575-4580

1984

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Development of the Renal Glucose Reabsorption Inhibitors: A New Mechanism for the Pharmacotherapy of Diabetes Mellitus Type 2

Differentiating sodium-glucose co-transporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus

Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats

Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

A Practical Stereoselective Synthesis and Novel Cocrystallizations of an Amphiphatic SGLT-2 Inhibitor

Exploring monocyclic core: Discovery of pyrrol-2-one derivatives as a new series of potent MCHR1 antagonists with in vivo efficacy

Sodium glucose co-transporter 2 (SGLT2) inhibitors: novel antidiabetic agents

Chemical analysis of cacao residues in archaeological ceramics from North America: considerations of contamination, sample size and systematic controls

The prehistoric drug trade: widespread consumption of cacao in Ancestral Pueblo and Hohokam communities in the American Southwest

Cacao consumption during the 8th century at Alkali Ridge, southeastern Utah

Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies

Identification of a Nonbasic Melanin Hormone Receptor 1 Antagonist as an Antiobesity Clinical Candidate

Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2

Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup

Discovery of pyrazine carboxamide CB1 antagonists: The introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series

C-Arylglucoside synthesis: triisopropylsilane as a selective reagent for the reduction of an anomeric C-phenyl ketal

Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-α-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141

Dapagliflozin, A Selective SGLT2 Inhibitor for Treatment of Diabetes

Synthesis and reactions of bicyclo[3.1.0]hexatrienes

Novel general approach for the assay and inhibition of hydrolytic enzymes utilizing suicide-inhibitory bifunctionally linked substrates (SIBLINKS): exemplified by a phospholipase A2 assay

Suicide-inhibitory bifunctionally linked substrates (SIBLINKS) as phospholipase A2 inhibitors

Role of the symbiotic algae of Plexaura homomalla in prostaglandin biosynthesis

Bishomoaromatic stabilization of bicyclic anions

Intramolecular nucleophilic catalysis during alkaline hydrolysis of nonenolizable .beta.-keto esters

Asymmetric induction arising from .sigma./.pi. interactions

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