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Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism

Nature communications, 2018-10, Vol.9 (1), p.4147-15, Article 4147

2018

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Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment

mBio, 2018-11, Vol.9 (6)

2018

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Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (40), p.16004-16011

2012

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Antigen 85C Inhibition Restricts Mycobacterium tuberculosis Growth through Disruption of Cord Factor Biosynthesis

Antimicrobial Agents and Chemotherapy, 2012-04, Vol.56 (4), p.1735-1743

2012

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Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography

Antimicrobial Agents and Chemotherapy, 2007-11, Vol.51 (11), p.3915-3923

2007

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New Evidence for the Complexity of the Population Structure of Mycobacterium tuberculosis Increases the Diagnostic and Biologic Challenges

American journal of respiratory and critical care medicine, 2016-12, Vol.194 (12), p.1448-1451

2016

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A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis

Methods in molecular biology (Clifton, N.J.), 2015, Vol.1285, p.293

2015

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Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation

Cell chemical biology, 2022-05, Vol.29 (5), p.716-729

2022

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Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations

Proceedings of the National Academy of Sciences - PNAS, 2017-06, Vol.114 (24), p.E4832-E4840

2017

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Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa

Antimicrobial agents and chemotherapy, 2019-09, Vol.63 (9)

2019

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N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets

Journal of the American Chemical Society, 2013-07, Vol.135 (27), p.9968-9971

2013

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N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis

Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (31), p.E4523-E4530

2016

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Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2015-10, Vol.59 (10), p.6521-6538

2015

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Synthetic Calanolides with Bactericidal Activity against Replicating and Nonreplicating Mycobacterium tuberculosis

Journal of medicinal chemistry, 2014-05, Vol.57 (9), p.3755-3772

2014

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Benzimidazole-based compounds kill Mycobacterium tuberculosis

European journal of medicinal chemistry, 2014-03, Vol.75, p.336-353

2014

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Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria

Journal of visualized experiments, 2016-12 (118)

2016

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Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria

Journal of visualized experiments, 2016-12 (118)

2016

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Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis

ACS infectious diseases, 2015-12, Vol.1 (12), p.580-585

2015

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Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis

ACS infectious diseases, 2018-05, Vol.4 (5), p.771-787

2018

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X-ray Structure of 4,4′-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14α-Demethylase (CYP51)

The Journal of biological chemistry, 2008-05, Vol.283 (22), p.15152-15159

2008

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Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (4), p.16004

2012

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Old fold in a new X-ray diffraction dataset? Low-resolution molecular replacement using representative structural templates can provide phase information

Proteins, structure, function, and bioinformatics, 2006-09, Vol.64 (4), p.923-930

2006

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X-ray structure of 4,4'-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14alpha-demethylase (CYP51)

The Journal of biological chemistry, 2008-05, Vol.283 (22), p.15152

2008

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X-ray Structure of 4,4′-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14α-Demethylase (CYP51)S

The Journal of biological chemistry, 2008-05, Vol.283 (22), p.15152-15159

2008

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X-ray Structure of 4,4â²-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14Î±-Demethylase (CYP51)

The Journal of biological chemistry, 2008-05, Vol.283 (22), p.15152

2008

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Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism

Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

Antigen 85C Inhibition Restricts Mycobacterium tuberculosis Growth through Disruption of Cord Factor Biosynthesis

Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography

New Evidence for the Complexity of the Population Structure of Mycobacterium tuberculosis Increases the Diagnostic and Biologic Challenges

A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis

Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation

Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations

Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa

N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis

Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis

Synthetic Calanolides with Bactericidal Activity against Replicating and Nonreplicating Mycobacterium tuberculosis

Benzimidazole-based compounds kill Mycobacterium tuberculosis

Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria

Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria

Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis

Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis

X-ray Structure of 4,4′-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14α-Demethylase (CYP51)

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

Old fold in a new X-ray diffraction dataset? Low-resolution molecular replacement using representative structural templates can provide phase information

X-ray structure of 4,4'-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14alpha-demethylase (CYP51)

X-ray Structure of 4,4′-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14α-Demethylase (CYP51)S

X-ray Structure of 4,4â²-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14Î±-Demethylase (CYP51)

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