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Nrf2 Activation Is a Potential Therapeutic Approach to Attenuate Diabetic Retinopathy

Investigative ophthalmology & visual science, 2018-02, Vol.59 (2), p.815-825

2018

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The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction

Cardiovascular diabetology, 2017-03, Vol.16 (1), p.33-33, Article 33

2017

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Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease

Diabetes (New York, N.Y.), 2014-09, Vol.63 (9), p.3091-3103

2014

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A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy

Clinical science (1979), 2016-08, Vol.130 (15), p.1375-1387

2016

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Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney

Journal of the American Society of Nephrology, 2012-10, Vol.23 (10), p.1663-1673

2012

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Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction

Current opinion in pharmacology, 2024-02, Vol.74, p.102429-102429, Article 102429

Ward, Keith W.

2024

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Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis

Radiation research, 2014-05, Vol.181 (5), p.512

2014

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Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity

American journal of physiology. Renal physiology, 2013-06, Vol.304 (12), p.F1438-F1446

2013

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A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance

Drug metabolism and disposition, 2004-06, Vol.32 (6), p.603-611

2004

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Protective Effects of a Coumarin Derivative in Diabetic Rats

Investigative ophthalmology & visual science, 2009-08, Vol.50 (8), p.3846-3852

2009

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A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. II. Volume of distribution and mean residence time

Drug metabolism and disposition, 2004-06, Vol.32 (6), p.612-619

2004

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A comprehensive analysis of the role of correction factors in the allometric predictivity of clearance from rat, dog, and monkey to humans

Journal of pharmaceutical sciences, 2004-10, Vol.93 (10), p.2522-2534

2004

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Quantitative determination of besifloxacin, a novel fluoroquinolone antimicrobial agent, in human tears by liquid chromatography–tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-05, Vol.867 (1), p.105-110

2008

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Preclinical pharmacokinetic properties of the P-glycoprotein inhibitor GF120918A (HCl salt of GF120918, 9,10-dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the mouse, rat, dog, and monkey

The Journal of pharmacology and experimental therapeutics, 2004-08, Vol.310 (2), p.703-709

2004

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Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells

Molecular vision, 2011-02, Vol.17, p.533-542

2011

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Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Journal of medicinal chemistry, 2002-06, Vol.45 (12), p.2615-2623

2002

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Correlation of tear inflammatory cytokines and matrix metalloproteinases with four dry eye diagnostic tests

Investigative ophthalmology & visual science, 2012-03, Vol.53 (3), p.1512-1518

2012

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Structure Activity Relationships of 5-, 6-, and 7-Methyl-Substituted Azepan-3-one Cathepsin K Inhibitors

Journal of medicinal chemistry, 2006-03, Vol.49 (5), p.1597-1612

2006

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Mechanisms Contributing to Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated with Bardoxolone Methyl

American journal of nephrology, 2014-01, Vol.39 (6), p.499-508

2014

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Superficial punctate fluorescein staining of the ocular surface

Optometry and vision science, 2008-01, Vol.85 (1), p.8

Ward, Keith W

2008

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Superficial Punctate Fluorescein Staining of the Ocular Surface

Optometry and vision science, 2008-01, Vol.85 (1), p.8-16

WARD, KEITH W.

2008

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Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Drug design, development and therapy, 2019-01, Vol.13, p.1259-1270

2019

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Comparison of the effect of multipurpose contact lens solutions on the viability of cultured corneal epithelial cells

Contact lens & anterior eye, 2009-08, Vol.32 (4), p.171-175

2009

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Exploration of the African green monkey as a preclinical pharmacokinetic model: intravenous pharmacokinetic parameters

Drug metabolism and disposition, 2008-04, Vol.36 (4), p.715-720

2008

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Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress

FEBS letters, 2014-06, Vol.588 (12), p.2115-2124

2014

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Nrf2 Activation Is a Potential Therapeutic Approach to Attenuate Diabetic Retinopathy

The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction

Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease

A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy

Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney

Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction

Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis

Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity

A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance

Protective Effects of a Coumarin Derivative in Diabetic Rats

A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. II. Volume of distribution and mean residence time

A comprehensive analysis of the role of correction factors in the allometric predictivity of clearance from rat, dog, and monkey to humans

Quantitative determination of besifloxacin, a novel fluoroquinolone antimicrobial agent, in human tears by liquid chromatography–tandem mass spectrometry

Preclinical pharmacokinetic properties of the P-glycoprotein inhibitor GF120918A (HCl salt of GF120918, 9,10-dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the mouse, rat, dog, and monkey

Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells

Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Correlation of tear inflammatory cytokines and matrix metalloproteinases with four dry eye diagnostic tests

Structure Activity Relationships of 5-, 6-, and 7-Methyl-Substituted Azepan-3-one Cathepsin K Inhibitors

Mechanisms Contributing to Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated with Bardoxolone Methyl

Superficial punctate fluorescein staining of the ocular surface

Superficial Punctate Fluorescein Staining of the Ocular Surface

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Comparison of the effect of multipurpose contact lens solutions on the viability of cultured corneal epithelial cells

Exploration of the African green monkey as a preclinical pharmacokinetic model: intravenous pharmacokinetic parameters

Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress

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