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Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

Structure (London), 2016-03, Vol.24 (3), p.469-476

2016

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Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors

Structure (London), 2015-07, Vol.23 (7), p.1271-1282

2015

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Protective hinge in insulin opens to enable its receptor engagement

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (33), p.E3395-E3404

2014

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Insulin receptor structure and its implications for the IGF-1 receptor

Current opinion in structural biology, 2007-12, Vol.17 (6), p.699-705

2007

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Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (15), p.6771-6776

2010

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Structural Determinants for High-Affinity Binding of Insulin-Like Growth Factor II to Insulin Receptor (IR)-A, the Exon 11 Minus Isoform of the IR

Molecular endocrinology (Baltimore, Md.), 2004-10, Vol.18 (10), p.2502-2512

2004

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The First Three Domains of the Insulin Receptor Differ Structurally from the Insulin-like Growth Factor 1 Receptor in the Regions Governing Ligand Specificity

Proceedings of the National Academy of Sciences - PNAS, 2006-08, Vol.103 (33), p.12429-12434

2006

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Is it time to retire the genus Rymovirus from the family Potyviridae?

Archives of virology, 2017-07, Vol.162 (7), p.2175-2179

Ward, Colin W.

2017

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How insulin engages its primary binding site on the insulin receptor

Nature (London), 2013-01, Vol.493 (7431), p.241-245

2013

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Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

BioEssays, 2009-04, Vol.31 (4), p.422-434

2009

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The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation

BioEssays, 2013-11, Vol.35 (11), p.945-954

2013

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Identification of the Epitope for the Epidermal Growth Factor Receptor-specific Monoclonal Antibody 806 Reveals That It Preferentially Recognizes an Untethered Form of the Receptor

The Journal of biological chemistry, 2004-07, Vol.279 (29), p.30375-30384

2004

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Epidermal growth factor receptor: mechanisms of activation and signalling

Experimental cell research, 2003-03, Vol.284 (1), p.31-53

2003

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Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

Nature (London), 1998-07, Vol.394 (6691), p.395-399

1998

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Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families

Current opinion in structural biology, 2012-06, Vol.22 (3), p.360-366

2012

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An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors

Molecular Cell, 2003-09, Vol.12 (3), p.541-552

2003

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Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor

The Journal of biological chemistry, 2016-07, Vol.291 (30), p.15473-15481

2016

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A Designed Ankyrin Repeat Protein Evolved to Picomolar Affinity to Her2

Journal of molecular biology, 2007-06, Vol.369 (4), p.1015-1028

2007

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Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α

Cell, 2002-09, Vol.110 (6), p.763-773

2002

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The Crystal Structure of a Truncated ErbB2 Ectodomain Reveals an Active Conformation, Poised to Interact with Other ErbB Receptors

Molecular cell, 2003-02, Vol.11 (2), p.495-505

2003

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The insulin and EGF receptor structures: new insights into ligand-induced receptor activation

Trends in biochemical sciences (Amsterdam. Regular ed.), 2007-03, Vol.32 (3), p.129-137

2007

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Structure of the insulin receptor ectodomain reveals a folded-over conformation

Nature, 2006-09, Vol.443 (7108), p.218-221

2006

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The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules

BMC bioinformatics, 2001-07, Vol.2 (1), p.4-4, Article 4

2001

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Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action

Biochemical journal, 2003-11, Vol.376 (Pt 1), p.123-134

2003

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Landmarks in insulin research

Frontiers in endocrinology (Lausanne), 2011, Vol.2, p.76-76

2011

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Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors

Protective hinge in insulin opens to enable its receptor engagement

Insulin receptor structure and its implications for the IGF-1 receptor

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

Structural Determinants for High-Affinity Binding of Insulin-Like Growth Factor II to Insulin Receptor (IR)-A, the Exon 11 Minus Isoform of the IR

The First Three Domains of the Insulin Receptor Differ Structurally from the Insulin-like Growth Factor 1 Receptor in the Regions Governing Ligand Specificity

Is it time to retire the genus Rymovirus from the family Potyviridae?

How insulin engages its primary binding site on the insulin receptor

Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation

Identification of the Epitope for the Epidermal Growth Factor Receptor-specific Monoclonal Antibody 806 Reveals That It Preferentially Recognizes an Untethered Form of the Receptor

Epidermal growth factor receptor: mechanisms of activation and signalling

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families

An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors

Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor

A Designed Ankyrin Repeat Protein Evolved to Picomolar Affinity to Her2

Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α

The Crystal Structure of a Truncated ErbB2 Ectodomain Reveals an Active Conformation, Poised to Interact with Other ErbB Receptors

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation

Structure of the insulin receptor ectodomain reveals a folded-over conformation

The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules

Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action

Landmarks in insulin research

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