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Camptothecin and taxol: from discovery to clinic

Journal of ethnopharmacology, 1996-04, Vol.51 (1), p.239-254

1996

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Macharistol, a New Cytotoxic Cinnamylphenol from the Stems of Machaerium aristulatum

Journal of natural products (Washington, D.C.), 2001-11, Vol.64 (11), p.1483-1485

2001

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DNA Topoisomerase I-Targeted Chemotherapy of Human Colon Cancer in Xenografts

Science (American Association for the Advancement of Science), 1989-11, Vol.246 (4933), p.1046-1048

1989

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Comparison of In Vitro Activities of Camptothecin and Nitidine Derivatives against Fungal and Cancer Cells

Antimicrobial Agents and Chemotherapy, 1999-12, Vol.43 (12), p.2862-2868

1999

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Novel strategies for the discovery of plant-derived anticancer agents

Pure and applied chemistry, 1999-09, Vol.71 (9), p.1611-1618

1999

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Interaction of an Alkylating Camptothecin Derivative with a DNA Base at Topoisomerase I-DNA Cleavage Sites

Proceedings of the National Academy of Sciences - PNAS, 1995-09, Vol.92 (19), p.8861-8865

1995

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Camptothecin and taxol : discovery to clinic : thirteenth Bruce F. Cain memorial Award lecture

Cancer research (Baltimore), 1995-02, Vol.55 (4), p.753-760

1995

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Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase. I: Evidence for a specific receptor site and a relation to antitumor activity

Cancer research (Chicago, Ill.), 1989-03, Vol.49 (6), p.1465-1469

1989

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Lipid bilayer partitioning and stability of camptothecin drugs

Biochemistry (Easton), 1993-05, Vol.32 (20), p.5352-5364

1993

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Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal

Phytomedicine (Stuttgart), 1996-11, Vol.3 (3), p.281-285

1996

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Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells

Cancer research (Chicago, Ill.), 1991-11, Vol.51 (22), p.6039-6044

1991

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Isolation of Symlandine from the Roots of Common Comfrey (Symphytum officinale) Using Countercurrent Chromatography

Journal of natural products (Washington, D.C.), 2001-02, Vol.64 (2), p.251-253

2001

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Water soluble 20(S)-glycinate esters of 10,11-methylenedioxycamptothecins are highly active against human breast cancer xenografts

Cancer research (Chicago, Ill.), 1999-07, Vol.59 (14), p.3424-3428

1999

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New Compounds with DNA Strand-Scission Activity from the Combined Leaf and Stem of Uvaria hamiltonii

Journal of natural products (Washington, D.C.), 1998-04, Vol.61 (4), p.446-450

1998

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Cytotoxic constituents from the roots of Tovomita brevistaminea

Phytochemistry (Oxford), 1999-10, Vol.52 (4), p.669-674

1999

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New biphenyl compounds with DNA strand-scission activity from Clusia paralicola

Journal of natural products (Washington, D.C.), 1999-11, Vol.62 (11), p.1484-1487

1999

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Antitrypanosomal activity of camptothecin analogs: Structure-activity correlations

Biochemical pharmacology, 1995-09, Vol.50 (7), p.937-942

1995

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Synergistic Antimicrobial Activity of Metabolites Produced by a Nonobligate Bacterial Predator

Antimicrobial Agents and Chemotherapy, 2003-07, Vol.47 (7), p.2113-2117

2003

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16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity

Proceedings of the National Academy of Sciences - PNAS, 1996-08, Vol.93 (16), p.8739-8744

1996

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Pentacyclic Triterpenes Derived from Maprounea africana Are Potent Inhibitors of HIV-1 Reverse Transcriptase

Journal of natural products (Washington, D.C.), 1994-03, Vol.57 (3), p.415-418

1994

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New bioactive aromatic compounds from Vismia guianensis

Phytochemistry (Oxford), 2000-09, Vol.55 (1), p.35-42

2000

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DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues

Cancer research (Chicago, Ill.), 1989-08, Vol.49 (16), p.4385-4389

1989

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Effects of D-ring substituents on antiprogestational (antagonist) and progestational (agonist) activity of 11β-aryl steroids

Human reproduction (Oxford), 1994-06, Vol.9 (suppl-1), p.32-39

1994

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Structure-Activity Studies of 2,3,4,4a,5,9b-Hexahydroindeno[1,2-c]pyridines as Antispermatogenic Agents for Male Contraception

Journal of medicinal chemistry, 1995-03, Vol.38 (5), p.753-763

1995

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7- and 10-Substituted Camptothecins: Dependence of Topoisomerase I-DNA Cleavable Complex Formation and Stability on the 7- and 10-Substituents

Molecular pharmacology, 2000-02, Vol.57 (2), p.243-251

2000

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Camptothecin and taxol: from discovery to clinic

Macharistol, a New Cytotoxic Cinnamylphenol from the Stems of Machaerium aristulatum

DNA Topoisomerase I-Targeted Chemotherapy of Human Colon Cancer in Xenografts

Comparison of In Vitro Activities of Camptothecin and Nitidine Derivatives against Fungal and Cancer Cells

Novel strategies for the discovery of plant-derived anticancer agents

Interaction of an Alkylating Camptothecin Derivative with a DNA Base at Topoisomerase I-DNA Cleavage Sites

Camptothecin and taxol : discovery to clinic : thirteenth Bruce F. Cain memorial Award lecture

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase. I: Evidence for a specific receptor site and a relation to antitumor activity

Lipid bilayer partitioning and stability of camptothecin drugs

Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal

Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells

Isolation of Symlandine from the Roots of Common Comfrey (Symphytum officinale) Using Countercurrent Chromatography

Water soluble 20(S)-glycinate esters of 10,11-methylenedioxycamptothecins are highly active against human breast cancer xenografts

New Compounds with DNA Strand-Scission Activity from the Combined Leaf and Stem of Uvaria hamiltonii

Cytotoxic constituents from the roots of Tovomita brevistaminea

New biphenyl compounds with DNA strand-scission activity from Clusia paralicola

Antitrypanosomal activity of camptothecin analogs: Structure-activity correlations

Synergistic Antimicrobial Activity of Metabolites Produced by a Nonobligate Bacterial Predator

16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity

Pentacyclic Triterpenes Derived from Maprounea africana Are Potent Inhibitors of HIV-1 Reverse Transcriptase

New bioactive aromatic compounds from Vismia guianensis

DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues

Effects of D-ring substituents on antiprogestational (antagonist) and progestational (agonist) activity of 11β-aryl steroids

Structure-Activity Studies of 2,3,4,4a,5,9b-Hexahydroindeno[1,2-c]pyridines as Antispermatogenic Agents for Male Contraception

7- and 10-Substituted Camptothecins: Dependence of Topoisomerase I-DNA Cleavable Complex Formation and Stability on the 7- and 10-Substituents

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