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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Nature medicine, 2015-06, Vol.21 (6), p.581-590

2015

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Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

Immunity (Cambridge, Mass.), 2020-07, Vol.53 (1), p.158-171.e6

2020

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Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase

Molecular therapy, 2017-09, Vol.25 (9), p.2189-2201

2017

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The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8 + T Cells

The Journal of immunology (1950), 2022-04, Vol.208 (7), p.1686-1699

2022

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Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells

Immunity (Cambridge, Mass.), 2022-01, Vol.55 (1), p.98-114.e5

2022

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Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8 + T cell subsets

Proceedings of the National Academy of Sciences - PNAS, 2022-10, Vol.119 (43), p.e2209021119-e2209021119

2022

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P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy

Cancer immunology research, 2022-07, Vol.10 (7), p.871-884

2022

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500 P2RX7 agonist treatment boosts the ability of IL-12-activated CD8+ T cells to infiltrate and control murine melanoma

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A307-A308

2020

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Abstract 2648: Chimeric antigen receptor T-cell therapy against anaplastic lymphoma kinase (ALK) is limited by target antigen density and CAR surface expression

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2648-2648

2016

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Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases

Protein expression and purification, 2014-04, Vol.96, p.32-38

2014

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The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses

iScience, 2024-07, Vol.27 (7), p.110290, Article 110290

2024

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TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

Science translational medicine, 2017-11, Vol.9 (417)

2017

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P2RX7 enhances tumor control by CD8+ T cells in adoptive cell therapy

The Journal of immunology (1950), 2022-05, Vol.208 (1_Supplement), p.120-120.11

2022

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The ATP-Exporting Hemichannel Pannexin-1 Promotes CD8+ T Cell Memory Establishment

The Journal of immunology (1950), 2021-05, Vol.206 (1_Supplement), p.103-103.19

2021

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Circulating KLRG1+ memory CD8 T cells support immune responses in non-lymphoid tissues

The Journal of immunology (1950), 2021-05, Vol.206 (1_Supplement), p.98-98.25

2021

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Expression of the purinergic receptor P2RX7 marks early effector CD8+ T cells with increased potential for both long-lived circulating and resident memory cell generation

The Journal of immunology (1950), 2021-05, Vol.206 (1_Supplement), p.98-98.26

2021

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Pannexin-1 channels promotes CD8+ T cell effector and memory responses through distinct metabolic pathways

The Journal of immunology (1950), 2023-05, Vol.210 (1_Supplement), p.226-226.15

2023

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Rapid cell cycling of both circulating and resident memory CD8+ T cells driven by common gamma chain-dependent cytokines

The Journal of immunology (1950), 2021-05, Vol.206 (1_Supplement), p.98-98.13

2021

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Common gamma chain-dependent cytokines drive antigen-independent proliferation of circulating and resident memory CD8+ T cells

The Journal of immunology (1950), 2022-05, Vol.208 (1_Supplement), p.45-45.03

2022

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Engagement of ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells

The Journal of immunology (1950), 2021-05, Vol.206 (1_Supplement), p.24-24.06

2021

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P2RX7: A Double-Edged Sword in Tumor Immunotherapy

Wanhainen, Kelsey Marie

2022

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Preclinical Development of a T-Cell ALL CAR Demonstrates That Differences in CAR Membrane Distribution May Impact Efficacy

Blood, 2016-12, Vol.128 (22), p.4019-4019

2016

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Gut Microbiota-Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms

Circulation (New York, N.Y.), 2023-04, Vol.147 (14), p.1079-1096

2023

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Prognostic value of D-dimer and markers of coagulation for stratification of abdominal aortic aneurysm growth

Blood advances, 2018-11, Vol.2 (22), p.3088-3096

2018

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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase

The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8 + T Cells

Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells

Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8 + T cell subsets

P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy

500 P2RX7 agonist treatment boosts the ability of IL-12-activated CD8+ T cells to infiltrate and control murine melanoma

Abstract 2648: Chimeric antigen receptor T-cell therapy against anaplastic lymphoma kinase (ALK) is limited by target antigen density and CAR surface expression

Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases

The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses

TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

P2RX7 enhances tumor control by CD8+ T cells in adoptive cell therapy

The ATP-Exporting Hemichannel Pannexin-1 Promotes CD8+ T Cell Memory Establishment

Circulating KLRG1+ memory CD8 T cells support immune responses in non-lymphoid tissues

Expression of the purinergic receptor P2RX7 marks early effector CD8+ T cells with increased potential for both long-lived circulating and resident memory cell generation

Pannexin-1 channels promotes CD8+ T cell effector and memory responses through distinct metabolic pathways

Rapid cell cycling of both circulating and resident memory CD8+ T cells driven by common gamma chain-dependent cytokines

Common gamma chain-dependent cytokines drive antigen-independent proliferation of circulating and resident memory CD8+ T cells

Engagement of ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells

P2RX7: A Double-Edged Sword in Tumor Immunotherapy

Preclinical Development of a T-Cell ALL CAR Demonstrates That Differences in CAR Membrane Distribution May Impact Efficacy

Gut Microbiota-Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms

Prognostic value of D-dimer and markers of coagulation for stratification of abdominal aortic aneurysm growth

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