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Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs

Pharmacological research, 2023-04, Vol.190, p.106724-106724, Article 106724

2023

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Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development

Biomedicine & pharmacotherapy, 2023-08, Vol.164, p.114956-114956, Article 114956

2023

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Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs

Biomedicine & pharmacotherapy, 2024-06, Vol.175, p.116644, Article 116644

2024

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P-Glycoprotein (ABCB1/MDR1) and BCRP (ABCG2) Limit Brain Accumulation and Cytochrome P450-3A (CYP3A) Restricts Oral Exposure of the RET Inhibitor Selpercatinib (RETEVMO)

Pharmaceuticals (Basel, Switzerland), 2021-10, Vol.14 (11), p.1087

2021

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Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism

Acta pharmaceutica Sinica. B, 2023-02, Vol.13 (2), p.618-631

2023

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OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation

British journal of pharmacology, 2020-07, Vol.177 (13), p.3060-3074

2020

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P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability

Pharmacological research, 2018-11, Vol.137, p.47-55

2018

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P‐glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450‐3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib

International journal of cancer, 2018-10, Vol.143 (8), p.2029-2038

2018

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ABCB1 and ABCG2, but not CYP3A4 limit oral availability and brain accumulation of the RET inhibitor pralsetinib

Pharmacological research, 2021-10, Vol.172, p.105850, Article 105850

2021

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Bioanalytical method for the simultaneous quantification of irinotecan and its active metabolite SN-38 in mouse plasma and tissue homogenates using HPLC-fluorescence

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020-07, Vol.1149, p.122177, Article 122177

2020

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P-glycoprotein (ABCB1/MDR1) limits brain accumulation and Cytochrome P450-3A (CYP3A) restricts oral availability of the novel FGFR4 inhibitor fisogatinib (BLU-554)

International journal of pharmaceutics, 2020-01, Vol.573, p.118842, Article 118842

2020

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P‐glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF‐β signaling pathway inhibitor galunisertib

International journal of cancer, 2020-03, Vol.146 (6), p.1631-1642

2020

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Quantitative bioanalytical assay for the selective RET inhibitors selpercatinib and pralsetinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020-06, Vol.1147, p.122131, Article 122131

2020

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Oral coadministration of elacridar and ritonavir enhances brain accumulation and oral availability of the novel ALK/ROS1 inhibitor lorlatinib

European journal of pharmaceutics and biopharmaceutics, 2019-03, Vol.136, p.120-130

2019

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Abstract 1268: The impact of P-glycoprotein, breast cancer resistance protein and CYP3A on pharmacokinetics and metabolism of galunisertib

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.1268-1268

2019

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Rifampin and ritonavir increase oral availability and elacridar enhances overall exposure and brain accumulation of the NTRK inhibitor larotrectinib

European journal of pharmaceutics and biopharmaceutics, 2022-01, Vol.170, p.197-207

2022

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Quantitative bioanalytical assay for the tropomyosin receptor kinase inhibitor larotrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018-12, Vol.1102-1103, p.167-172

2018

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The Impact of Different Preservation Conditions and Freezing-Thawing Cycles on Quality of RNA, DNA, and Proteins in Cancer Tissue

Biopreservation and biobanking, 2015-10, Vol.13 (5), p.335

2015

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CD55 limits sensitivity to complement-dependent cytolysis triggered by heterologous expression of α-gal xenoantigen in colon tumor cells

American journal of physiology: Gastrointestinal and liver physiology, 2014-06, Vol.306 (12), p.G1056-G1064

2014

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CD55 limits sensitivity to complement-dependent cytolysis triggered by heterologous expression of [alpha]-gal xenoantigen in colon tumor cells

American journal of physiology: Gastrointestinal and liver physiology, 2014-06, Vol.306 (12), p.G1056

2014

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Stochastic grey water footprint model based on uncertainty analysis theory

Ecological indicators, 2021-05, Vol.124, p.107444, Article 107444

2021

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The indirect impacts of nonpharmacological COVID-19 control measures on other infectious diseases in Yinchuan, Northwest China: a time series study

BMC public health, 2023-06, Vol.23 (1), p.1089-1089, Article 1089

2023

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Effects of silencing TT8 and HB12 on in vitro nutrients degradation and VFA production in relation to molecular structures of alfalfa (Medicago sativa)

Journal of the science of food and agriculture, 2019-12, Vol.99 (15), p.6850-6858

2019

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Snow Cover and Climate Change and Their Coupling Effects on Runoff in the Keriya River Basin during 2001–2020

Remote sensing (Basel, Switzerland), 2023-07, Vol.15 (13), p.3435

2023

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What Is the Threshold Elevation at Which Climatic Factors Determine Snow Cover Variability? A Case Study of the Keriya River Basin

Remote sensing (Basel, Switzerland), 2023-10, Vol.15 (19), p.4725

2023

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Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs

Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development

Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs

P-Glycoprotein (ABCB1/MDR1) and BCRP (ABCG2) Limit Brain Accumulation and Cytochrome P450-3A (CYP3A) Restricts Oral Exposure of the RET Inhibitor Selpercatinib (RETEVMO)

Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism

OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation

P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability

P‐glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450‐3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib

ABCB1 and ABCG2, but not CYP3A4 limit oral availability and brain accumulation of the RET inhibitor pralsetinib

Bioanalytical method for the simultaneous quantification of irinotecan and its active metabolite SN-38 in mouse plasma and tissue homogenates using HPLC-fluorescence

P-glycoprotein (ABCB1/MDR1) limits brain accumulation and Cytochrome P450-3A (CYP3A) restricts oral availability of the novel FGFR4 inhibitor fisogatinib (BLU-554)

P‐glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF‐β signaling pathway inhibitor galunisertib

Quantitative bioanalytical assay for the selective RET inhibitors selpercatinib and pralsetinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry

Oral coadministration of elacridar and ritonavir enhances brain accumulation and oral availability of the novel ALK/ROS1 inhibitor lorlatinib

Abstract 1268: The impact of P-glycoprotein, breast cancer resistance protein and CYP3A on pharmacokinetics and metabolism of galunisertib

Rifampin and ritonavir increase oral availability and elacridar enhances overall exposure and brain accumulation of the NTRK inhibitor larotrectinib

Quantitative bioanalytical assay for the tropomyosin receptor kinase inhibitor larotrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry

The Impact of Different Preservation Conditions and Freezing-Thawing Cycles on Quality of RNA, DNA, and Proteins in Cancer Tissue

CD55 limits sensitivity to complement-dependent cytolysis triggered by heterologous expression of α-gal xenoantigen in colon tumor cells

CD55 limits sensitivity to complement-dependent cytolysis triggered by heterologous expression of [alpha]-gal xenoantigen in colon tumor cells

Stochastic grey water footprint model based on uncertainty analysis theory

The indirect impacts of nonpharmacological COVID-19 control measures on other infectious diseases in Yinchuan, Northwest China: a time series study

Effects of silencing TT8 and HB12 on in vitro nutrients degradation and VFA production in relation to molecular structures of alfalfa (Medicago sativa)

Snow Cover and Climate Change and Their Coupling Effects on Runoff in the Keriya River Basin during 2001–2020

What Is the Threshold Elevation at Which Climatic Factors Determine Snow Cover Variability? A Case Study of the Keriya River Basin

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