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Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

Cells (Basel, Switzerland), 2019-07, Vol.8 (7), p.727

2019

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The revised human liver cytochrome P450 "Pie": absolute protein quantification of CYP4F and CYP3A enzymes using targeted quantitative proteomics

Drug metabolism and disposition, 2014-08, Vol.42 (8), p.1241-1251

2014

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Pharmacokinetics, Trypanosoma brucei gambiense Efficacy, and Time of Drug Action of DB829, a Preclinical Candidate for Treatment of Second-Stage Human African Trypanosomiasis

Antimicrobial Agents and Chemotherapy, 2013-11, Vol.57 (11), p.5330-5343

2013

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Pharmacokinetic Comparison To Determine the Mechanisms Underlying the Differential Efficacies of Cationic Diamidines against First- and Second-Stage Human African Trypanosomiasis

Antimicrobial agents and chemotherapy, 2014-07, Vol.58 (7), p.4064-4074

2014

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Novel Arylimidamides for Treatment of Visceral Leishmaniasis

Antimicrobial Agents and Chemotherapy, 2010-06, Vol.54 (6), p.2507-2516

2010

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Physiologically based pharmacokinetic model for miltefosine in mice

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100975, Article 100975

2024

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Development of a UPLC-MRM-based targeted proteomic method to profile subcellular organelle marker proteins from human liver tissues

Scientific reports, 2022-06, Vol.12 (1), p.10985-10985, Article 10985

2022

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Cytochrome P450 and flavin-containing monooxygenase families: age-dependent differences in expression and functional activity

Pediatric research, 2018-02, Vol.83 (2), p.527-535

2018

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Evaluation of Arylimidamides DB1955 and DB1960 as Candidates against Visceral Leishmaniasis and Chagas' Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology Studies

Antimicrobial Agents and Chemotherapy, 2012-07, Vol.56 (7), p.3690-3699

2012

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Ethnic variability in the expression of hepatic drug transporters: absolute quantification by an optimized targeted quantitative proteomic approach

Drug metabolism and disposition, 2015-07, Vol.43 (7), p.1045-1055

2015

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N-substituted-4-(pyridin-4-ylalkyl)piperazine-1-carboxamides and related compounds as Leishmania CYP51 and CYP5122A1 inhibitors

Bioorganic & medicinal chemistry, 2024-11, Vol.113, p.117907, Article 117907

2024

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A gel-free MS-based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes

Proteomics (Weinheim), 2008-10, Vol.8 (20), p.4186-4196

2008

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Antileishmanial activity of a series of N²,N⁴-disubstituted quinazoline-2,4-diamines

Journal of medicinal chemistry, 2014-06, Vol.57 (12), p.5141-5156

2014

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Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key intermediate sterol that supports a branched ergosterol biosynthetic pathway

International journal for parasitology -- drugs and drug resistance, 2022-12, Vol.20, p.27-42

2022

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In Vitro and In Vivo Evaluation of 28DAP010, a Novel Diamidine for Treatment of Second-Stage African Sleeping Sickness

Antimicrobial agents and chemotherapy, 2014-08, Vol.58 (8), p.4452-4463

2014

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Quantification of Neonatal Fc Receptor and Beta-2 Microglobulin in Human Liver Tissues by Ultraperformance Liquid Chromatography-Multiple Reaction Monitoring-based Targeted Quantitative Proteomics for Applications in Biotherapeutic Physiologically-based Pharmacokinetic Models

Drug metabolism and disposition, 2020-10, Vol.48 (10), p.925-933

2020

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CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.1985-1994

2006

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Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models

The Journal of pharmacology and experimental therapeutics, 2011-05, Vol.337 (2), p.503-512

2011

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Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine

Drug metabolism and disposition, 2007-11, Vol.35 (11), p.2067-2075

2007

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Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation

Bioorganic & medicinal chemistry, 2011-01, Vol.19 (1), p.513-523

2011

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Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A

Proceedings of the National Academy of Sciences - PNAS, 2007-10, Vol.104 (42), p.16564-16569

2007

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Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis

PLoS neglected tropical diseases, 2013-06, Vol.7 (6), p.e2230

2013

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Determining tissue distribution of the oral antileishmanial agent miltefosine: a physiologically-based pharmacokinetic modeling approach

Antimicrobial agents and chemotherapy, 2024-07, Vol.68 (7), p.e0032824

2024

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Improving Eflornithine Oral Bioavailability and Brain Uptake by Modulating Intercellular Junctions With an E-cadherin Peptide

Journal of pharmaceutical sciences, 2019-12, Vol.108 (12), p.3870-3878

2019

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Multiphase flow experiment and simulation for cells-on-a-chip devices

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 2019-04, Vol.233 (4), p.432-443

2019

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Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

The revised human liver cytochrome P450 "Pie": absolute protein quantification of CYP4F and CYP3A enzymes using targeted quantitative proteomics

Pharmacokinetics, Trypanosoma brucei gambiense Efficacy, and Time of Drug Action of DB829, a Preclinical Candidate for Treatment of Second-Stage Human African Trypanosomiasis

Pharmacokinetic Comparison To Determine the Mechanisms Underlying the Differential Efficacies of Cationic Diamidines against First- and Second-Stage Human African Trypanosomiasis

Novel Arylimidamides for Treatment of Visceral Leishmaniasis

Physiologically based pharmacokinetic model for miltefosine in mice

Development of a UPLC-MRM-based targeted proteomic method to profile subcellular organelle marker proteins from human liver tissues

Cytochrome P450 and flavin-containing monooxygenase families: age-dependent differences in expression and functional activity

Evaluation of Arylimidamides DB1955 and DB1960 as Candidates against Visceral Leishmaniasis and Chagas' Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology Studies

Ethnic variability in the expression of hepatic drug transporters: absolute quantification by an optimized targeted quantitative proteomic approach

N-substituted-4-(pyridin-4-ylalkyl)piperazine-1-carboxamides and related compounds as Leishmania CYP51 and CYP5122A1 inhibitors

A gel-free MS-based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes

Antileishmanial activity of a series of N²,N⁴-disubstituted quinazoline-2,4-diamines

Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key intermediate sterol that supports a branched ergosterol biosynthetic pathway

In Vitro and In Vivo Evaluation of 28DAP010, a Novel Diamidine for Treatment of Second-Stage African Sleeping Sickness

Quantification of Neonatal Fc Receptor and Beta-2 Microglobulin in Human Liver Tissues by Ultraperformance Liquid Chromatography-Multiple Reaction Monitoring-based Targeted Quantitative Proteomics for Applications in Biotherapeutic Physiologically-based Pharmacokinetic Models

CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]

Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models

Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine

Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation

Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A

Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis

Determining tissue distribution of the oral antileishmanial agent miltefosine: a physiologically-based pharmacokinetic modeling approach

Improving Eflornithine Oral Bioavailability and Brain Uptake by Modulating Intercellular Junctions With an E-cadherin Peptide

Multiphase flow experiment and simulation for cells-on-a-chip devices

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