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Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning

Nature communications, 2019-09, Vol.10 (1), p.4284-14, Article 4284

2019

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A compact Cas9 ortholog from Staphylococcus Auricularis (SauriCas9) expands the DNA targeting scope

PLoS biology, 2020-03, Vol.18 (3), p.e3000686-e3000686

2020

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Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing

Genome Biology, 2021-03, Vol.22 (1), p.86-23, Article 86

2021

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An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells

Scientific reports, 2017-05, Vol.7 (1), p.2320-11, Article 2320

2017

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Dinickel(II) Complexes of Bis(N-heterocyclic carbene) Ligands Containing [Ni2(μ-OH)] Cores as Highly Efficient Catalysts for the Coupling of Aryl Chlorides

Organometallics, 2008-11, Vol.27 (22), p.5911-5920

2008

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The crystal structure of 4-aminiumbiphenyl benzenesulfonate, C18H17NO3S

Zeitschrift für Kristallographie. New crystal structures, 2023-10, Vol.238 (5), p.945-947

2023

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The crystal structure of 5,7-dinitropyrazolo[5,1-b]quinazolin-9(4H)-one, C10H5N5O5

Zeitschrift für Kristallographie. New crystal structures, 2023-08, Vol.238 (4), p.775-777

2023

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Approaches and Vectors for Efficient Cochlear Gene Transfer in Adult Mouse Models

Biomolecules (Basel, Switzerland), 2022-12, Vol.13 (1), p.38

2022

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Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss

Molecular therapy. Nucleic acids, 2022-09, Vol.29, p.400-412

2022

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Structural insights into Cas9 mismatch: promising for development of high-fidelity Cas9 variants

Signal transduction and targeted therapy, 2022-08, Vol.7 (1), p.271-271, Article 271

2022

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krCRISPR: an easy and efficient strategy for generating conditional knockout of essential genes in cells

Journal of biological engineering, 2019-04, Vol.13 (1), p.35-35, Article 35

2019

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Mechanisms and otoprotective strategies of programmed cell death on aminoglycoside-induced ototoxicity

Frontiers in cell and developmental biology, 2024-01, Vol.11, p.1305433-1305433

2024

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A Series of Four-Connected Entangled Metal–Organic Frameworks Assembled from Pamoic Acid and Pyridine-Containing Ligands: Interpenetrating, Self-Penetrating, and Supramolecular Isomerism

Crystal growth & design, 2012-01, Vol.12 (1), p.79-92

2012

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Mononuclear, dinuclear, hexanuclear, and one-dimensional polymeric silver complexes having ligand-supported and unsupported argentophilic interactions stabilized by pincer-like 2,6-bis(5-pyrazolyl)pyridine ligands

Dalton transactions : an international journal of inorganic chemistry, 2008 (11), p.1444

2008

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Rescue of mis-splicing of a common SLC26A4 mutant associated with sensorineural hearing loss by antisense oligonucleotides

Molecular therapy. Nucleic acids, 2022-06, Vol.28, p.280-292

2022

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Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and nonhuman primates

Molecular therapy. Methods & clinical development, 2023-12, Vol.31, p.101154-101154, Article 101154

2023

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Uniting Ruthenium(II) and Platinum(II) Polypyridine Centers in Heteropolymetallic Complexes Giving Strong Two-Photon Absorption

Inorganic chemistry, 2015-12, Vol.54 (23), p.11450-11456

2015

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Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing

Signal transduction and targeted therapy, 2022-03, Vol.7 (1), p.79-79, Article 79

2022

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Cas12aVDet: A CRISPR/Cas12a-Based Platform for Rapid and Visual Nucleic Acid Detection

Analytical chemistry (Washington), 2019-10, Vol.91 (19), p.12156-12161

2019

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Engineering of the AAV-Compatible Hair Cell-Specific Small-Size Myo15 Promoter for Gene Therapy in the Inner Ear

Research (Washington), 2024, Vol.7, p.0341-0341

2024

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A Highly Sensitive GFP Activation Assay for Detection of DNA Cleavage in Cells

Frontiers in cell and developmental biology, 2021-11, Vol.9, p.771248-771248

2021

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Seven supramolecular frameworks constructed from combination of hydrogen-bonds and other non-covalent associations between organic acids and bis-imidazoles

Journal of molecular structure, 2015-11, Vol.1099, p.304-316

2015

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HSD17B12 dosage insufficiency induced premature ovarian insufficiency in humans and mice

Clinical and translational medicine, 2022-02, Vol.12 (2), p.e737-n/a

2022

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Advances in gene therapy hold promise for treating hereditary hearing loss

Molecular therapy, 2023-04, Vol.31 (4), p.934-950

2023

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Metal coordination architectures of N-propionyl-1-hydroxy-2-naphthoylhydrazide: From metalladiazamacrocycles to trinuclear complexes

Journal of solid state chemistry, 2010-09, Vol.183 (9), p.2144-2153

2010

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Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning

A compact Cas9 ortholog from Staphylococcus Auricularis (SauriCas9) expands the DNA targeting scope

Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing

An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells

Dinickel(II) Complexes of Bis(N-heterocyclic carbene) Ligands Containing [Ni2(μ-OH)] Cores as Highly Efficient Catalysts for the Coupling of Aryl Chlorides

The crystal structure of 4-aminiumbiphenyl benzenesulfonate, C18H17NO3S

The crystal structure of 5,7-dinitropyrazolo[5,1-b]quinazolin-9(4H)-one, C10H5N5O5

Approaches and Vectors for Efficient Cochlear Gene Transfer in Adult Mouse Models

Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss

Structural insights into Cas9 mismatch: promising for development of high-fidelity Cas9 variants

krCRISPR: an easy and efficient strategy for generating conditional knockout of essential genes in cells

Mechanisms and otoprotective strategies of programmed cell death on aminoglycoside-induced ototoxicity

A Series of Four-Connected Entangled Metal–Organic Frameworks Assembled from Pamoic Acid and Pyridine-Containing Ligands: Interpenetrating, Self-Penetrating, and Supramolecular Isomerism

Mononuclear, dinuclear, hexanuclear, and one-dimensional polymeric silver complexes having ligand-supported and unsupported argentophilic interactions stabilized by pincer-like 2,6-bis(5-pyrazolyl)pyridine ligands

Rescue of mis-splicing of a common SLC26A4 mutant associated with sensorineural hearing loss by antisense oligonucleotides

Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and nonhuman primates

Uniting Ruthenium(II) and Platinum(II) Polypyridine Centers in Heteropolymetallic Complexes Giving Strong Two-Photon Absorption

Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing

Cas12aVDet: A CRISPR/Cas12a-Based Platform for Rapid and Visual Nucleic Acid Detection

Engineering of the AAV-Compatible Hair Cell-Specific Small-Size Myo15 Promoter for Gene Therapy in the Inner Ear

A Highly Sensitive GFP Activation Assay for Detection of DNA Cleavage in Cells

Seven supramolecular frameworks constructed from combination of hydrogen-bonds and other non-covalent associations between organic acids and bis-imidazoles

HSD17B12 dosage insufficiency induced premature ovarian insufficiency in humans and mice

Advances in gene therapy hold promise for treating hereditary hearing loss

Metal coordination architectures of N-propionyl-1-hydroxy-2-naphthoylhydrazide: From metalladiazamacrocycles to trinuclear complexes

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