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Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Nature communications, 2018-06, Vol.9 (1), p.2550-12, Article 2550

2018

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Variation of gut microbiota caused by an imbalance diet is detrimental to bugs' survival

The Science of the total environment, 2021-06, Vol.771, p.144880-144880, Article 144880

2021

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Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2

Leukemia, 2022-04, Vol.36 (4), p.1048-1057

2022

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Comparative Analysis of Adelphocoris suturalis Jakovlev (Hemiptera: Miridae) Immune Responses to Fungal and Bacterial Pathogens

Frontiers in physiology, 2021-03, Vol.12, p.646721-646721

2021

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Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib‐induced KIT mutations in gastrointestinal stromal tumours

Molecular oncology, 2022-04, Vol.16 (8), p.1761-1774

2022

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Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models

Investigational new drugs, 2020-10, Vol.38 (5), p.1272-1281

2020

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Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia

Haematologica (Roma), 2021-02, Vol.106 (2), p.605

2021

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Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

Signal transduction and targeted therapy, 2021-09, Vol.6 (1), p.334-334, Article 334

2021

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Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent

Acta pharmaceutica Sinica. B, 2020-03, Vol.10 (3), p.488-497

2020

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Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy

Acta pharmaceutica Sinica. B, 2023-09, Vol.13 (9), p.3694-3707

2023

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Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells

Oncotarget, 2015-10, Vol.6 (31), p.31313-31322

2015

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Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model

Scientific reports, 2017-03, Vol.7 (1), p.466-466, Article 466

2017

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Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies

Signal transduction and targeted therapy, 2023-01, Vol.8 (1), p.18-18, Article 18

2023

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Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus

Signal transduction and targeted therapy, 2023-04, Vol.8 (1), p.143-143, Article 143

2023

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Low dose of emetine as potential anti-SARS-CoV-2 virus therapy: preclinical in vitro inhibition and in vivo pharmacokinetic evidences

Molecular biomedicine, 2020-11, Vol.1 (1), p.14-9, Article 14

2020

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Construction, identification, and immunogenic assessments of an HSV-1 mutant vaccine with a UL18 deletion

Acta virologica (Anglickâa verze), 2018, Vol.62 (2), p.164

2018

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Discovery of a highly selective KIT kinase primary V559D mutant inhibitor for gastrointestinal stromal tumors (GISTs)

Oncotarget, 2017-12, Vol.8 (67), p.111110-111118

2017

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Clinical efficacy of low-dose emetine for patients with COVID-19: a real-world study

Journal of bio-X research, 2021-06, Vol.4 (2), p.53-59

2021

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Discovery of a highly potent and selective Bruton's tyrosine kinase inhibitor avoiding impairment of ADCC effects for B-cell non-Hodgkin lymphoma

Signal transduction and targeted therapy, 2020-09, Vol.5 (1), p.200-200, Article 200

2020

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Adaptive complementary sliding mode control of ship course under environmental disturbance

Ocean engineering, 2024-11, Vol.312, p.119016, Article 119016

2024

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A novel PDGFR inhibitor WQ-C-401 prevents pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension

Experimental cell research, 2024-08, Vol.441 (1), p.114154, Article 114154

2024

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Positive feedback loops between fibroblasts and the mechanical environment contribute to dermal fibrosis

Matrix biology, 2023-08, Vol.121, p.1-21

2023

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Discovery of Pyrazolo1,5-apyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors

Journal of medicinal chemistry, 2024-08

2024

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Salviachinensines A–F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis

Journal of natural products (Washington, D.C.), 2018-11, Vol.81 (11), p.2531-2538

2018

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Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors

European journal of medicinal chemistry, 2022-12, Vol.243, p.114782-114782, Article 114782

2022

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Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Variation of gut microbiota caused by an imbalance diet is detrimental to bugs' survival

Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2

Comparative Analysis of Adelphocoris suturalis Jakovlev (Hemiptera: Miridae) Immune Responses to Fungal and Bacterial Pathogens

Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib‐induced KIT mutations in gastrointestinal stromal tumours

Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models

Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia

Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent

Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells

Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model

Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies

Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus

Low dose of emetine as potential anti-SARS-CoV-2 virus therapy: preclinical in vitro inhibition and in vivo pharmacokinetic evidences

Construction, identification, and immunogenic assessments of an HSV-1 mutant vaccine with a UL18 deletion

Discovery of a highly selective KIT kinase primary V559D mutant inhibitor for gastrointestinal stromal tumors (GISTs)

Clinical efficacy of low-dose emetine for patients with COVID-19: a real-world study

Discovery of a highly potent and selective Bruton's tyrosine kinase inhibitor avoiding impairment of ADCC effects for B-cell non-Hodgkin lymphoma

Adaptive complementary sliding mode control of ship course under environmental disturbance

A novel PDGFR inhibitor WQ-C-401 prevents pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension

Positive feedback loops between fibroblasts and the mechanical environment contribute to dermal fibrosis

Discovery of Pyrazolo1,5-apyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors

Salviachinensines A–F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis

Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors

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