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ESKAPEing the labyrinth of antibacterial discovery

Nature reviews. Drug discovery, 2015-08, Vol.14 (8), p.529-542

2015

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Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (29), p.11663-11668

2012

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New Biarsenical Ligands and Tetracysteine Motifs for Protein Labeling in Vitro and in Vivo: Synthesis and Biological Applications

Journal of the American Chemical Society, 2002-05, Vol.124 (21), p.6063-6076

2002

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Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

Antimicrobial Agents and Chemotherapy, 2012-03, Vol.56 (3), p.1240-1246

2012

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Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo

Antimicrobial Agents and Chemotherapy, 2011-03, Vol.55 (3), p.1088-1096

2011

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New directions using reporter enzyme fluorescence (REF) as a tuberculosis diagnostic platform

Tuberculosis (Edinburgh, Scotland), 2016-12, Vol.101, p.S78-S82

2016

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Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

Antimicrobial Agents and Chemotherapy, 2013-12, Vol.57 (12), p.6005-6015

2013

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Secreted Gaussia princeps luciferase as a reporter of Escherichia coli replication in a mouse tissue cage model of infection

PloS one, 2014-03, Vol.9 (3), p.e90382-e90382

2014

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Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases

The Journal of biological chemistry, 2013-09, Vol.288 (39), p.27960-27971

2013

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Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC

Journal of antimicrobial chemotherapy, 2015-06, Vol.70 (6), p.1650-1658

2015

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Translating slow-binding inhibition kinetics into cellular and in vivo effects

Nature chemical biology, 2015-06, Vol.11 (6), p.416-423

2015

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Rapid Tuberculosis Diagnosis Using Reporter Enzyme Fluorescence

Journal of clinical microbiology, 2019-12, Vol.57 (12)

2019

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Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914

The Journal of biological chemistry, 2015-08, Vol.290 (34), p.20984-20994

2015

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Fluorescent Sensors for Zn2+ Based on a Fluorescein Platform: Synthesis, Properties and Intracellular Distribution

Journal of the American Chemical Society, 2001-08, Vol.123 (32), p.7831-7841

2001

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A New Cell-Permeable Fluorescent Probe for Zn2

Journal of the American Chemical Society, 2000-06, Vol.122 (23), p.5644-5645

2000

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Eskapeing the labyrinth of antibacterial discovery

Nature reviews. Drug discovery, 2015-09, Vol.14 (9), p.662-662

2015

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Fluorescent Chemosensors for Divalent Zinc Based on Zinc Finger Domains. Enhanced Oxidative Stability, Metal Binding Affinity, and Structural and Functional Characterization

Journal of the American Chemical Society, 1997-04, Vol.119 (15), p.3443-3450

1997

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Design and Evaluation of a Peptidyl Fluorescent Chemosensor for Divalent Zinc

Journal of the American Chemical Society, 1996-03, Vol.118 (12), p.3053-3054

1996

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A high-throughput fluorescence resonance energy transfer-based assay for DNA ligase

Journal of biomolecular screening, 2011-06, Vol.16 (5), p.486-493

2011

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Structure Guided Understanding of NAD+ Recognition in Bacterial DNA Ligases

ACS chemical biology, 2012-03, Vol.7 (3), p.571-580

2012

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A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase

Journal of biomolecular screening, 2011-06, Vol.16 (5), p.494-505

2011

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Stereoselective Synthesis of Fluorescent α-Amino Acids Containing Oxine (8-Hydroxyquinoline) and Their Peptide Incorporation in Chemosensors for Divalent Zinc

Journal of organic chemistry, 1998-09, Vol.63 (19), p.6727-6731

1998

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Peptidyl chemosensors incorporating a fret mechanism for detection of Ni(II)

Bioorganic & medicinal chemistry letters, 1998-08, Vol.8 (15), p.1963-1968

1998

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Completing the Screen: Biochemical Cascades to Prioritize HTS Output

The FASEB journal, 2011-04, Vol.25, p.314.3-314.3

Walkup, Grant K

2011

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Exploiting Polypeptide Motifs for the Design of Selective Cu(II) Ion Chemosensors

Journal of the American Chemical Society, 1998-01, Vol.120 (3), p.609-610

1998

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ESKAPEing the labyrinth of antibacterial discovery

Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor

New Biarsenical Ligands and Tetracysteine Motifs for Protein Labeling in Vitro and in Vivo: Synthesis and Biological Applications

Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo

New directions using reporter enzyme fluorescence (REF) as a tuberculosis diagnostic platform

Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

Secreted Gaussia princeps luciferase as a reporter of Escherichia coli replication in a mouse tissue cage model of infection

Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases

Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC

Translating slow-binding inhibition kinetics into cellular and in vivo effects

Rapid Tuberculosis Diagnosis Using Reporter Enzyme Fluorescence

Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914

Fluorescent Sensors for Zn2+ Based on a Fluorescein Platform: Synthesis, Properties and Intracellular Distribution

A New Cell-Permeable Fluorescent Probe for Zn2

Eskapeing the labyrinth of antibacterial discovery

Fluorescent Chemosensors for Divalent Zinc Based on Zinc Finger Domains. Enhanced Oxidative Stability, Metal Binding Affinity, and Structural and Functional Characterization

Design and Evaluation of a Peptidyl Fluorescent Chemosensor for Divalent Zinc

A high-throughput fluorescence resonance energy transfer-based assay for DNA ligase

Structure Guided Understanding of NAD+ Recognition in Bacterial DNA Ligases

A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase

Stereoselective Synthesis of Fluorescent α-Amino Acids Containing Oxine (8-Hydroxyquinoline) and Their Peptide Incorporation in Chemosensors for Divalent Zinc

Peptidyl chemosensors incorporating a fret mechanism for detection of Ni(II)

Completing the Screen: Biochemical Cascades to Prioritize HTS Output

Exploiting Polypeptide Motifs for the Design of Selective Cu(II) Ion Chemosensors

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