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Targeting co-stimulatory molecules in autoimmune disease

Nature reviews. Drug discovery, 2020-12, Vol.19 (12), p.860-883

2020

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Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

Science (American Association for the Advancement of Science), 2011-04, Vol.332 (6029), p.600-603

2011

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The link between circulating follicular helper T cells and autoimmunity

Nature reviews. Immunology, 2022-09, Vol.22 (9), p.567-575

Walker, Lucy S. K.

2022

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CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (2), p.524-529

2015

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Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity

Nature communications, 2022-11, Vol.13 (1), p.6757-6757, Article 6757

2022

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Publisher Correction: Targeting co-stimulatory molecules in autoimmune disease

Nature reviews. Drug discovery, 2021, Vol.20 (1), p.82-82

2021

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Treg and CTLA-4: Two intertwining pathways to immune tolerance

Journal of autoimmunity, 2013-09, Vol.45 (100), p.49-57

Walker, Lucy S.K

2013

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Author Correction: Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity

Nature communications, 2023-09, Vol.14 (1), p.5724-5724, Article 5724

2023

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CTLA4 gene polymorphism and autoimmunity

Immunological reviews, 2005-04, Vol.204 (1), p.102-115

2005

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Targeting TFH cells in human diseases and vaccination: rationale and practice

Nature immunology, 2022-08, Vol.23 (8), p.1157-1168

2022

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Confusing signals: Recent progress in CTLA-4 biology

Trends in immunology, 2015-02, Vol.36 (2), p.63-70

2015

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The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses

Nature reviews. Immunology, 2011-12, Vol.11 (12), p.852-863

2011

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Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

Nature immunology, 2022-09, Vol.23 (9), p.1365-1378

2022

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The immunology of type 1 diabetes

Nature reviews. Immunology, 2024-06, Vol.24 (6), p.435

2024

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Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes

Nature immunology, 2020-10, Vol.21 (10), p.1244-1255

2020

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1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3

The Journal of immunology (1950), 2009-11, Vol.183 (9), p.5458-5467

2009

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Acquisition of Suppressive Function by Activated Human CD4+CD25- T Cells Is Associated with the Expression of CTLA-4 Not FoxP3

The Journal of immunology (1950), 2008-08, Vol.181 (3), p.1683-1691

2008

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Release from Regulatory T Cell-Mediated Suppression during the Onset of Tissue-Specific Autoimmunity Is Associated with Elevated IL-21

The Journal of immunology (1950), 2008-04, Vol.180 (8), p.5393-5401

2008

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Epithelial Inflammation Is Associated with CCL28 Production and the Recruitment of Regulatory T Cells Expressing CCR10

Journal of Immunology, 2006-07, Vol.177 (1), p.593-603

2006

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T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship

Frontiers in immunology, 2018-08, Vol.9, p.1941-1941

2018

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IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis

Blood, 2012-05, Vol.119 (20), p.4656-4664

2012

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Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells

The Journal of experimental medicine, 2018-04, Vol.215 (4), p.1227-1243

2018

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IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (31), p.12668-12673

2012

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CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4

Frontiers in immunology, 2020-12, Vol.11, p.600000-600000

2020

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Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs

Immunological reviews, 2014-05, Vol.259 (1), p.23-39

2014

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Targeting co-stimulatory molecules in autoimmune disease

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

The link between circulating follicular helper T cells and autoimmunity

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity

Publisher Correction: Targeting co-stimulatory molecules in autoimmune disease

Treg and CTLA-4: Two intertwining pathways to immune tolerance

Author Correction: Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity

CTLA4 gene polymorphism and autoimmunity

Targeting TFH cells in human diseases and vaccination: rationale and practice

Confusing signals: Recent progress in CTLA-4 biology

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

The immunology of type 1 diabetes

Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes

1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3

Acquisition of Suppressive Function by Activated Human CD4+CD25- T Cells Is Associated with the Expression of CTLA-4 Not FoxP3

Release from Regulatory T Cell-Mediated Suppression during the Onset of Tissue-Specific Autoimmunity Is Associated with Elevated IL-21

Epithelial Inflammation Is Associated with CCL28 Production and the Recruitment of Regulatory T Cells Expressing CCR10

T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship

IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis

Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells

IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells

CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4

Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs

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