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Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

Nature cell biology, 2016-08, Vol.18 (8), p.897

2016

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Targeting mutant p53 in cancer: a long road to precision therapy

The FEBS journal, 2017-03, Vol.284 (6), p.837-850

2017

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Parkin Levels Decrease in Fibroblasts With Progranulin (PGRN) Pathogenic Variants and in a Cellular Model of PGRN Deficiency

Frontiers in molecular neuroscience, 2021-05, Vol.14, p.676478-676478

2021

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The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

Biochemical journal, 2011-04, Vol.435 (1), p.127-142

2011

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A Driver Never Works Alone—Interplay Networks of Mutant p53, MYC, RAS, and Other Universal Oncogenic Drivers in Human Cancer

Cancers, 2020-06, Vol.12 (6), p.1532

2020

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Hsp90 Regulates the Activity of Wild Type p53 under Physiological and Elevated Temperatures

The Journal of biological chemistry, 2004-11, Vol.279 (47), p.48846-48854

2004

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Mutant p53-Nrf2 axis regulates the proteasome machinery in cancer

Molecular & cellular oncology, 2017-01, Vol.4 (1), p.e1217967-e1217967

2017

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Hsp90 Chaperones Wild-type p53 Tumor Suppressor Protein

The Journal of biological chemistry, 2004-11, Vol.279 (47), p.48836-48845

2004

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The rebel angel: mutant p53 as the driving oncogene in breast cancer

Carcinogenesis (New York), 2012-11, Vol.33 (11), p.2007-2017

2012

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The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin

Molecular cancer, 2010-06, Vol.9 (1), p.147-147, Article 147

2010

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The rebel angel: mutant p53 as the driving oncogene in breast cancer

Carcinogenesis (New York), 2012-11, Vol.33 (11), p.2007-2017

2012

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Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells

Oncotarget, 2018-04, Vol.9 (29), p.20508-20523

2018

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Multi-omics reveals global effects of mutant p53 gain-of-function

Cell cycle (Georgetown, Tex.), 2016-11, Vol.15 (22), p.3009-3010

2016

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Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a "dominant-positive" mechanism

Oncotarget, 2018-08, Vol.9 (62), p.32063-32080

2018

Volltextzugriff (PDF)

The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells

Cell reports (Cambridge), 2022-09, Vol.40 (13), p.111428-111428, Article 111428

2022

Volltextzugriff (PDF)

ATP Binding to Hsp90 Is Sufficient for Effective Chaperoning of p53 Protein

The Journal of biological chemistry, 2010-10, Vol.285 (42), p.32020-32028

2010

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Identification of a HLA-A0201-restricted immunogenic epitope from the universal tumor antigen DEPDC1

Oncoimmunology, 2017-08, Vol.6 (8), p.e1313371-e1313371

2017

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Cooperation of p53 mutations with other oncogenic alterations in cancer

Sub-cellular biochemistry, 2014, Vol.85, p.41

2014

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Psc3 cohesin of Schizosaccharomyces pombe: cell cycle analysis and identification of three distinct isoforms

Biological chemistry, 2005-07, Vol.386 (7), p.613-621

2005

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Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

Targeting mutant p53 in cancer: a long road to precision therapy

Parkin Levels Decrease in Fibroblasts With Progranulin (PGRN) Pathogenic Variants and in a Cellular Model of PGRN Deficiency

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

A Driver Never Works Alone—Interplay Networks of Mutant p53, MYC, RAS, and Other Universal Oncogenic Drivers in Human Cancer

Hsp90 Regulates the Activity of Wild Type p53 under Physiological and Elevated Temperatures

Mutant p53-Nrf2 axis regulates the proteasome machinery in cancer

Hsp90 Chaperones Wild-type p53 Tumor Suppressor Protein

The rebel angel: mutant p53 as the driving oncogene in breast cancer

The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin

The rebel angel: mutant p53 as the driving oncogene in breast cancer

Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells

Multi-omics reveals global effects of mutant p53 gain-of-function

Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a "dominant-positive" mechanism

The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells

ATP Binding to Hsp90 Is Sufficient for Effective Chaperoning of p53 Protein

Identification of a HLA-A0201-restricted immunogenic epitope from the universal tumor antigen DEPDC1

Cooperation of p53 mutations with other oncogenic alterations in cancer

Psc3 cohesin of Schizosaccharomyces pombe: cell cycle analysis and identification of three distinct isoforms

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