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Comparing MDI and DPI Aerosol Deposition Using In Vitro Experiments and a New Stochastic Individual Path (SIP) Model of the Conducting Airways

Pharmaceutical research, 2012-06, Vol.29 (6), p.1670-1688

2012

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Current Inhalers Deliver Very Small Doses to the Lower Tracheobronchial Airways: Assessment of Healthy and Constricted Lungs

Journal of pharmaceutical sciences, 2016-01, Vol.105 (1), p.147-159

2016

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Impact of Vehicle Physicochemical Properties on Modeling-Based Predictions of Cyclosporine Ophthalmic Emulsion Bioavailability and Tear Film Breakup Time

Journal of pharmaceutical sciences, 2019-01, Vol.108 (1), p.620-629

2019

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Development of a stochastic individual path (SIP) model for predicting the tracheobronchial deposition of pharmaceutical aerosols: Effects of transient inhalation and sampling the airways

Journal of aerosol science, 2011-11, Vol.42 (11), p.781-799

2011

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Use of the Same Model or Modeling Strategy Across Multiple Submissions: Focus on Complex Drug Products

The AAPS journal, 2024-01, Vol.26 (1), p.12-12, Article 12

2024

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Development of characteristic upper tracheobronchial airway models for testing pharmaceutical aerosol delivery

Journal of biomechanical engineering, 2013-09, Vol.135 (9), p.91010

2013

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Scientific and regulatory activities initiated by the U.S. Food and drug administration to foster approvals of generic dry powder inhalers: Bioequivalence perspective

Advanced drug delivery reviews, 2022-11, Vol.190, p.114526, Article 114526

2022

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In Silico Methods for Development of Generic Drug–Device Combination Orally Inhaled Drug Products

CPT: pharmacometrics and systems pharmacology, 2019-06, Vol.8 (6), p.359-370

2019

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Scientific and regulatory activities initiated by the U.S. food and drug administration to foster approvals of generic dry powder inhalers: Quality perspective

Advanced drug delivery reviews, 2022-10, Vol.189, p.114519-114519, Article 114519

2022

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Pharmaceutical aerosols deposition patterns from a Dry Powder Inhaler: Euler Lagrangian prediction and validation

Medical engineering & physics, 2017-04, Vol.42, p.35-47

2017

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Aerosol Drug Delivery During Noninvasive Positive Pressure Ventilation: Effects of Intersubject Variability and Excipient Enhanced Growth

Journal of aerosol medicine and pulmonary drug delivery, 2017-06, Vol.30 (3), p.190

2017

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Mechanistic modeling of generic orally inhaled drug products: A workshop summary report

CPT: pharmacometrics and systems pharmacology, 2023-05, Vol.12 (5), p.560-574

2023

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Mechanistic Understanding of High Flow Nasal Cannula Therapy and Pressure Support with an In Vitro Infant Model

Annals of biomedical engineering, 2020-02, Vol.48 (2), p.624-633

2020

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Regulatory utility of mechanistic modeling to support alternative bioequivalence approaches: A workshop overview

CPT: pharmacometrics and systems pharmacology, 2023-05, Vol.12 (5), p.619-623

2023

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Variability in nose-to-lung aerosol delivery

Journal of aerosol science, 2014-12, Vol.78, p.11-29

2014

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Creation of an in vitro biomechanical model of the trachea using rapid prototyping

Journal of biomechanics, 2014-06, Vol.47 (8), p.1861-1868

2014

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A quasi‐3D wire approach to model pulmonary airflow in human airways

International journal for numerical methods in biomedical engineering, 2017-07, Vol.33 (7), p.n/a

2017

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High-efficiency generation and delivery of aerosols through nasal cannula during noninvasive ventilation

Journal of aerosol medicine and pulmonary drug delivery, 2013-10, Vol.26 (5), p.266

2013

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Mechanistic modeling of ophthalmic, nasal, injectable, and implant generic drug products: A workshop summary report

CPT: pharmacometrics and systems pharmacology, 2023-05, Vol.12 (5), p.631-638

2023

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Development of a Transient Flow Aerosol Mixer-Heater System for Lung Delivery of Nasally Administered Aerosols Using a Nasal Cannula

Aerosol science and technology, 2014-10, Vol.48 (10), p.1009-1021

2014

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A quasi-3D model of the whole lung: airway extension to the tracheobronchial limit using the constrained constructive optimization and alveolar modeling, using a sac–trumpet model

Journal of Computational Design and Engineering , 2021, 8(2), , pp.691-704

2021

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Computational analysis of a 3D mucociliary clearance model predicting nasal drug uptake

Journal of aerosol science, 2021-06, Vol.155, p.105757, Article 105757

2021

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Leveraging Modeling and Simulation to Enhance the Efficiency of Bioequivalence Approaches for Generic Drugs: Highlights from the 2023 Generic Drug Science and Research Initiatives Public Workshop

The AAPS journal, 2024-04, Vol.26 (3), p.45, Article 45

2024

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Current Inhalers Deliver Very Small Doses to the Lower Tracheobronchial Airways: Assessment of Healthy and Constricted Lungs: Pharmaceutics, Drug Delivery and Pharmaceutical Technology

Journal of pharmaceutical sciences, 2016-01, Vol.105 (1), p.147-159

2016

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Transport and deposition of beclomethasone dipropionate drug aerosols with varying ethanol concentration in severe asthmatic subjects

International journal of pharmaceutics, 2023-04, Vol.636, p.122805-122805, Article 122805

2023

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Comparing MDI and DPI Aerosol Deposition Using In Vitro Experiments and a New Stochastic Individual Path (SIP) Model of the Conducting Airways

Current Inhalers Deliver Very Small Doses to the Lower Tracheobronchial Airways: Assessment of Healthy and Constricted Lungs

Impact of Vehicle Physicochemical Properties on Modeling-Based Predictions of Cyclosporine Ophthalmic Emulsion Bioavailability and Tear Film Breakup Time

Development of a stochastic individual path (SIP) model for predicting the tracheobronchial deposition of pharmaceutical aerosols: Effects of transient inhalation and sampling the airways

Use of the Same Model or Modeling Strategy Across Multiple Submissions: Focus on Complex Drug Products

Development of characteristic upper tracheobronchial airway models for testing pharmaceutical aerosol delivery

Scientific and regulatory activities initiated by the U.S. Food and drug administration to foster approvals of generic dry powder inhalers: Bioequivalence perspective

In Silico Methods for Development of Generic Drug–Device Combination Orally Inhaled Drug Products

Scientific and regulatory activities initiated by the U.S. food and drug administration to foster approvals of generic dry powder inhalers: Quality perspective

Pharmaceutical aerosols deposition patterns from a Dry Powder Inhaler: Euler Lagrangian prediction and validation

Aerosol Drug Delivery During Noninvasive Positive Pressure Ventilation: Effects of Intersubject Variability and Excipient Enhanced Growth

Mechanistic modeling of generic orally inhaled drug products: A workshop summary report

Mechanistic Understanding of High Flow Nasal Cannula Therapy and Pressure Support with an In Vitro Infant Model

Regulatory utility of mechanistic modeling to support alternative bioequivalence approaches: A workshop overview

Variability in nose-to-lung aerosol delivery

Creation of an in vitro biomechanical model of the trachea using rapid prototyping

A quasi‐3D wire approach to model pulmonary airflow in human airways

High-efficiency generation and delivery of aerosols through nasal cannula during noninvasive ventilation

Mechanistic modeling of ophthalmic, nasal, injectable, and implant generic drug products: A workshop summary report

Development of a Transient Flow Aerosol Mixer-Heater System for Lung Delivery of Nasally Administered Aerosols Using a Nasal Cannula

A quasi-3D model of the whole lung: airway extension to the tracheobronchial limit using the constrained constructive optimization and alveolar modeling, using a sac–trumpet model

Computational analysis of a 3D mucociliary clearance model predicting nasal drug uptake

Leveraging Modeling and Simulation to Enhance the Efficiency of Bioequivalence Approaches for Generic Drugs: Highlights from the 2023 Generic Drug Science and Research Initiatives Public Workshop

Current Inhalers Deliver Very Small Doses to the Lower Tracheobronchial Airways: Assessment of Healthy and Constricted Lungs: Pharmaceutics, Drug Delivery and Pharmaceutical Technology

Transport and deposition of beclomethasone dipropionate drug aerosols with varying ethanol concentration in severe asthmatic subjects

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