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Fatty acid metabolism: target for metabolic syndrome

Journal of lipid research, 2009-04, Vol.50 (Suppl), p.S138-S143

2009

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Acetyl-CoA Carboxylase 2−/− Mutant Mice are Protected against Fatty Liver under High-fat, High-carbohydrate Dietary and de Novo Lipogenic Conditions

The Journal of biological chemistry, 2012-04, Vol.287 (15), p.12578-12588

2012

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Lipid Metabolism

Wakil, Salih

1, 1970

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Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (44), p.18831-18836

2009

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Acetyl-CoA Carboxylase 2 Mutant Mice Are Protected against Obesity and Diabetes Induced by High-Fat/High-Carbohydrate Diets

Proceedings of the National Academy of Sciences - PNAS, 2003-09, Vol.100 (18), p.10207-10212

2003

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Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

Proceedings of the National Academy of Sciences - PNAS, 2007-10, Vol.104 (42), p.16480-16485

2007

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Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (22), p.8552-8557

2006

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Mutant Mice Lacking Acetyl-CoA Carboxylase 1 Are Embryonically Lethal

Proceedings of the National Academy of Sciences - PNAS, 2005-08, Vol.102 (34), p.12011-12016

2005

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Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2

Science (American Association for the Advancement of Science), 2001-03, Vol.291 (5513), p.2613-2616

2001

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Structure and function of animal fatty acid synthase

Lipids, 2004-11, Vol.39 (11), p.1045-1053

2004

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Human Fatty Acid Synthase: Structure and Substrate Selectivity of the Thioesterase Domain

Proceedings of the National Academy of Sciences - PNAS, 2004-11, Vol.101 (44), p.15567-15572

2004

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Fatty Acid Synthesis Is Essential in Embryonic Development: Fatty Acid Synthase Null Mutants and Most of the Heterozygotes Die in utero

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (11), p.6358-6363

2003

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Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (5), p.1384-1389

2005

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aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues

Proceedings of the National Academy of Sciences - PNAS, 2009-10, Vol.106 (41), p.17576-17581

2009

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Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-γ-linolenic acid

Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (38), p.15757-15762

2011

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Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule

Biochemical journal, 2012-12, Vol.448 (3), p.409-416

2012

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Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4923-4927

2011

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Fatty acid synthase, a proficient multifunctional enzyme

Biochemistry (Easton), 1989-05, Vol.28 (11), p.4523-4530

Wakil, Salih J

1989

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Experimental Verification of Conformational Variation of Human Fatty Acid Synthase as Predicted by Normal Mode Analysis

Structure (London), 2004-02, Vol.12 (2), p.185-191

2004

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Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice

American journal of physiology. Heart and circulatory physiology, 2008-07, Vol.295 (1), p.H256-H265

2008

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The Subcellular Localization of Acetyl-CoA Carboxylase 2

Proceedings of the National Academy of Sciences - PNAS, 2000-02, Vol.97 (4), p.1444-1449

2000

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Saccharomyces cerevisiae mutant strain defective in acetyl-CoA carboxylase arrests at the G₂/M phase of the cell cycle

Proceedings of the National Academy of Sciences - PNAS, 2003-03, Vol.100 (6), p.3095-3100

2003

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Domain Movements in Human Fatty Acid Synthase by Quantized Elastic Deformational Model

Proceedings of the National Academy of Sciences - PNAS, 2002-06, Vol.99 (12), p.7895-7899

2002

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Human Acetyl-CoA Carboxylase 1 Gene: Presence of Three Promoters and Heterogeneity at the 5′-Untranslated mRNA Region

Proceedings of the National Academy of Sciences - PNAS, 2003-06, Vol.100 (13), p.7515-7520

2003

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Human Fatty Acid Synthase: Role of Interdomain in the Formation of Catalytically Active Synthase Dimer

Proceedings of the National Academy of Sciences - PNAS, 2001-03, Vol.98 (6), p.3104-3108

2001

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Fatty acid metabolism: target for metabolic syndrome

Acetyl-CoA Carboxylase 2−/− Mutant Mice are Protected against Fatty Liver under High-fat, High-carbohydrate Dietary and de Novo Lipogenic Conditions

Lipid Metabolism

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

Acetyl-CoA Carboxylase 2 Mutant Mice Are Protected against Obesity and Diabetes Induced by High-Fat/High-Carbohydrate Diets

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis

Mutant Mice Lacking Acetyl-CoA Carboxylase 1 Are Embryonically Lethal

Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2

Structure and function of animal fatty acid synthase

Human Fatty Acid Synthase: Structure and Substrate Selectivity of the Thioesterase Domain

Fatty Acid Synthesis Is Essential in Embryonic Development: Fatty Acid Synthase Null Mutants and Most of the Heterozygotes Die in utero

Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice

aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues

Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-γ-linolenic acid

Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule

Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins

Fatty acid synthase, a proficient multifunctional enzyme

Experimental Verification of Conformational Variation of Human Fatty Acid Synthase as Predicted by Normal Mode Analysis

Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice

The Subcellular Localization of Acetyl-CoA Carboxylase 2

Saccharomyces cerevisiae mutant strain defective in acetyl-CoA carboxylase arrests at the G₂/M phase of the cell cycle

Domain Movements in Human Fatty Acid Synthase by Quantized Elastic Deformational Model

Human Acetyl-CoA Carboxylase 1 Gene: Presence of Three Promoters and Heterogeneity at the 5′-Untranslated mRNA Region

Human Fatty Acid Synthase: Role of Interdomain in the Formation of Catalytically Active Synthase Dimer

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