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Elongator and the role of its subcomplexes in human diseases

EMBO molecular medicine, 2023-02, Vol.15 (2), p.e16418-n/a

2023

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The Many Faces of Elongator in Neurodevelopment and Disease

Frontiers in molecular neuroscience, 2016-11, Vol.9, p.115-115

2016

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Inhibition of CDK4/6 by Palbociclib Significantly Extends Survival in Medulloblastoma Patient-Derived Xenograft Mouse Models

Clinical cancer research, 2017-10, Vol.23 (19), p.5802-5813

2017

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Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility

Genome medicine, 2021-02, Vol.13 (1), p.19-19, Article 19

2021

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Correction: Proliferation of Murine Midbrain Neural Stem Cells Depends upon an Endogenous Sonic Hedgehog (Shh) Source

PloS one, 2020-09, Vol.15 (9), p.e0239995-e0239995

2020

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Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors

PloS one, 2011-02, Vol.6 (2), p.e14680-e14680

2011

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MicroRNA Biogenesis and Hedgehog-Patched Signaling Cooperate to Regulate an Important Developmental Transition in Granule Cell Development

Genetics (Austin), 2016-03, Vol.202 (3), p.1105-1118

2016

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Nuclear factor one transcription factors: Divergent functions in developmental versus adult stem cell populations

Developmental dynamics, 2015-03, Vol.244 (3), p.227-238

2015

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Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

Nature communications, 2018-08, Vol.9 (1), p.3195-13, Article 3195

2018

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A novel ELP1 mutation impairs the function of the Elongator complex and causes a severe neurodevelopmental phenotype

Journal of human genetics, 2023-07, Vol.68 (7), p.445-453

2023

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Editorial: Bench to bedside: translating pre-clinical research into clinical trials for childhood brain tumors

Frontiers in oncology, 2023, Vol.13, p.1274465

2023

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Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release

The Journal of experimental medicine, 2021-05, Vol.218 (5)

2021

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Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells

Cancer cell, 2008-08, Vol.14 (2), p.135-145

2008

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Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (20), p.7859-7864

2012

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Sex-Related Disparities in Acute Limb Ischemia Treatment Outcomes

Annals of vascular surgery, 2023-09, Vol.95, p.133-141

2023

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Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse

The Journal of experimental medicine, 2021-09, Vol.218 (9)

2021

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Paradigm Shift of Interventional Strategies and Outcomes for Acute Limb Ischemia Post-Pandemic

Journal of endovascular therapy, 2024-04, p.15266028241246162-15266028241246162

2024

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Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source

PloS one, 2013-06, Vol.8 (6), p.e65818-e65818

2013

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Efficient detection and monitoring of pediatric brain malignancies with liquid biopsy based on patient-specific somatic mutation screening

Neuro-oncology (Charlottesville, Va.), 2023-08, Vol.25 (8), p.1507-1517

2023

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Functional divergence of the two Elongator subcomplexes during neurodevelopment

EMBO molecular medicine, 2022-07, Vol.14 (7), p.e15608-n/a

2022

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Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis

Development (Cambridge), 2012-11, Vol.139 (22), p.4152-4161

2012

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Patient-derived orthotopic xenograft models of medulloblastoma lack a functional blood-brain barrier

Neuro-oncology (Charlottesville, Va.), 2021-05, Vol.23 (5), p.732-742

2021

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Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition

Genome medicine, 2023-05, Vol.15 (1), p.29-29, Article 29

2023

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MicroRNAs Promote Granule Cell Expansion in the Cerebellum Through Gli2

Cerebellum (London, England), 2015-12, Vol.14 (6), p.688-698

2015

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Patched 1 and Patched 2 Redundancy Has a Key Role in Regulating Epidermal Differentiation

Journal of investigative dermatology, 2014-07, Vol.134 (7), p.1981-1990

2014

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Elongator and the role of its subcomplexes in human diseases

The Many Faces of Elongator in Neurodevelopment and Disease

Inhibition of CDK4/6 by Palbociclib Significantly Extends Survival in Medulloblastoma Patient-Derived Xenograft Mouse Models

Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility

Correction: Proliferation of Murine Midbrain Neural Stem Cells Depends upon an Endogenous Sonic Hedgehog (Shh) Source

Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors

MicroRNA Biogenesis and Hedgehog-Patched Signaling Cooperate to Regulate an Important Developmental Transition in Granule Cell Development

Nuclear factor one transcription factors: Divergent functions in developmental versus adult stem cell populations

Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

A novel ELP1 mutation impairs the function of the Elongator complex and causes a severe neurodevelopmental phenotype

Editorial: Bench to bedside: translating pre-clinical research into clinical trials for childhood brain tumors

Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release

Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells

Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model

Sex-Related Disparities in Acute Limb Ischemia Treatment Outcomes

Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse

Paradigm Shift of Interventional Strategies and Outcomes for Acute Limb Ischemia Post-Pandemic

Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source

Efficient detection and monitoring of pediatric brain malignancies with liquid biopsy based on patient-specific somatic mutation screening

Functional divergence of the two Elongator subcomplexes during neurodevelopment

Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis

Patient-derived orthotopic xenograft models of medulloblastoma lack a functional blood-brain barrier

Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition

MicroRNAs Promote Granule Cell Expansion in the Cerebellum Through Gli2

Patched 1 and Patched 2 Redundancy Has a Key Role in Regulating Epidermal Differentiation

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