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Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics

PloS one, 2016-08, Vol.11 (8), p.e0160890-e0160890

2016

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Crystal structure of a eukaryotic phosphate transporter

Nature (London), 2013-04, Vol.496 (7446), p.533-536

2013

Volltextzugriff (PDF)

Structure and mechanism of a pentameric formate channel

Nature structural & molecular biology, 2010-01, Vol.17 (1), p.31

2010

Volltextzugriff (PDF)

Structural basis for alternating access of a eukaryotic calcium/proton exchanger

Nature (London), 2013-07, Vol.499 (7456), p.107-110

2013

Volltextzugriff (PDF)

A machine learning strategy for the identification of key in silico descriptors and prediction models for IgG monoclonal antibody developability properties

mAbs, 2023-12, Vol.15 (1), p.2248671-2248671

2023

Volltextzugriff (PDF)

Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates

Molecular cancer therapeutics, 2018-12, Vol.17 (12), p.2633-2642

2018

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Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates

Molecular cancer therapeutics, 2016-05, Vol.15 (5), p.938-945

2016

Volltextzugriff (PDF)

Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR + and Heterogeneous Tumor Models

Molecular cancer therapeutics, 2018-08, Vol.17 (8), p.1752-1760

2018

Volltextzugriff (PDF)

A previously undescribed tubulin binder

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (38), p.13684-13685

2014

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Engineering an Enhanced EGFR Engager: Humanization of Cetuximab for Improved Developability

Antibodies (Basel), 2022-01, Vol.11 (1), p.6

2022

Volltextzugriff (PDF)

Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation

Journal of molecular biology, 2016-07, Vol.428 (15), p.2981-2988

2016

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Codon Optimization Using a Recurrent Neural Network

Journal of computational biology, 2023-01, Vol.30 (1), p.70

2023

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ACE2-Fc fusion protein overcomes viral escape by potently neutralizing SARS-CoV-2 variants of concern

Antiviral research, 2022-03, Vol.199, p.105271-105271, Article 105271

2022

Volltextzugriff (PDF)

Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux-positive Tumor Models

Molecular cancer therapeutics, 2021-02, Vol.20 (2), p.320-328

2021

Volltextzugriff (PDF)

Structure-activity relationships of tubulysin analogues

Bioorganic & medicinal chemistry letters, 2020-07, Vol.30 (14), p.127241-127241, Article 127241

2020

Volltextzugriff (PDF)

Ion selectivity and gating mechanisms of FNT channels

Current opinion in structural biology, 2013-08, Vol.23 (4), p.499-506

2013

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Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation

ChemMedChem, 2021-04, Vol.16 (7), p.1077-1081

2021

Volltextzugriff (PDF)

Front Cover: Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation (ChemMedChem 7/2021)

ChemMedChem, 2021-04, Vol.16 (7), p.1047-1047

2021

Volltextzugriff (PDF)

Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics

PloS one, 2016-08, Vol.11 (8)

2016

Volltextzugriff (PDF)

Abstract 2803: Novel auristatins with high activity on efflux-positive models and demonstrable bystander activity

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2803-2803

2018

Volltextzugriff (PDF)

Abstract 930: Targeted delivery of cytotoxic NAMPT inhibitors using antibody-drug conjugates

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.930-930

2018

Volltextzugriff (PDF)

Abstract 1649: Impact of linker and conjugation site on tubulysin M ADC stability and in vivo activity

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1649-1649

2018

Volltextzugriff (PDF)

Abstract 983: Antibody-drug conjugates of NAMPT inhibitors: Discovery, optimization, and preclinical characterization

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.983-983

2019

Volltextzugriff (PDF)

A machine learning strategy for the identification of key in silico descriptors and prediction models for IgG monoclonal antibody developability properties

mAbs, 2023, Vol.15 (1)

2023

Volltextzugriff (PDF)

Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence

PloS one, 2007-08, Vol.2 (8), p.e753-e753

2007

Volltextzugriff (PDF)

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Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics

Crystal structure of a eukaryotic phosphate transporter

Structure and mechanism of a pentameric formate channel

Structural basis for alternating access of a eukaryotic calcium/proton exchanger

A machine learning strategy for the identification of key in silico descriptors and prediction models for IgG monoclonal antibody developability properties

Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates

Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates

Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR + and Heterogeneous Tumor Models

A previously undescribed tubulin binder

Engineering an Enhanced EGFR Engager: Humanization of Cetuximab for Improved Developability

Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation

Codon Optimization Using a Recurrent Neural Network

ACE2-Fc fusion protein overcomes viral escape by potently neutralizing SARS-CoV-2 variants of concern

Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux-positive Tumor Models

Structure-activity relationships of tubulysin analogues

Ion selectivity and gating mechanisms of FNT channels

Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation

Front Cover: Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation (ChemMedChem 7/2021)

Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics

Abstract 2803: Novel auristatins with high activity on efflux-positive models and demonstrable bystander activity

Abstract 930: Targeted delivery of cytotoxic NAMPT inhibitors using antibody-drug conjugates

Abstract 1649: Impact of linker and conjugation site on tubulysin M ADC stability and in vivo activity

Abstract 983: Antibody-drug conjugates of NAMPT inhibitors: Discovery, optimization, and preclinical characterization

A machine learning strategy for the identification of key in silico descriptors and prediction models for IgG monoclonal antibody developability properties

Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence

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