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Exploring protein hotspots by optimized fragment pharmacophores

Nature communications, 2021-05, Vol.12 (1), p.3201-10, Article 3201

2021

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Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue

American journal of physiology. Regulatory, integrative and comparative physiology, 1998-07, Vol.275 (1), p.291-R299

1998

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Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist

The Journal of pharmacology and experimental therapeutics, 2005-06, Vol.313 (3), p.1263

2005

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Structure and ligand recognition of the phosphotyrosine binding domain of Shc

Nature (London), 1995-12, Vol.378 (6557), p.584-592

1995

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Synthesis and structure–activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (16), p.4495-4498

2008

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Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI)

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4224-4227

2008

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Design of peptides that bind in the minor groove of DNA at 5'-(A,T)G(A,T)C(A,T)-3' sequences by a dimeric side-by-side motif

Journal of the American Chemical Society, 1992-11, Vol.114 (23), p.8783-8794

1992

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Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (23), p.6151-6155

2008

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The Pineal Gland: Photoreception and Coupling of Behavioral, Metabolic, and Cardiovascular Circadian Outputs

Journal of biological rhythms, 1995-03, Vol.10 (1), p.64-79

1995

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Structure–activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (16), p.4491-4494

2008

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Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4922-4930

2006

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Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (17), p.4450-4457

2006

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Binding affinities of synthetic peptides, pyridine-2-carboxamidonetropsin and 1-methylimidazole-2-carboxamidonetropsin, that form 2:1 complexes in the minor groove of double-helical DNA

Biochemistry (Easton), 1993-10, Vol.32 (42), p.11385-11389

1993

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A high-throughput chemotaxis assay for pharmacological characterization of chemokine receptors: Utilization of U937 monocytic cells

Journal of pharmacological and toxicological methods, 2005-03, Vol.51 (2), p.105-114

2005

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The suprachiasmatic nucleus controls the circadian rhythm of heart rate via the sympathetic nervous system

Physiology & behavior, 1994-06, Vol.55 (6), p.1091-1099

1994

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Engineering metal coordination sites into the antibody light chain

Journal of the American Chemical Society, 1993-06, Vol.115 (11), p.4449-4456

1993

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Alteration of the sequence specificity of distamycin on DNA by replacement of an N-methylpyrrolecarboxamide with pyridine-2-carboxamide

Journal of the American Chemical Society, 1987-03, Vol.109 (5), p.1574-1575

1987

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Application of Base Cleavable Safety Catch Linkers to Solid Phase Library Production

Journal of combinatorial chemistry, 2000-05, Vol.2 (3), p.266-275

2000

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Pinealectomized Rats Entrain and Phase-Shift to Melatonin Injections in a Dose-Dependent Manner

Journal of biological rhythms, 1993, Vol.8 (3), p.233-245

1993

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A highly specific metal-activated catalytic antibody

Journal of the American Chemical Society, 1993-06, Vol.115 (11), p.4906-4907

1993

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Antiparallel Side-by-Side Dimeric Motif for Sequence-Specific Recognition in the Minor Groove of DNA by the Designed Peptide 1-Methylimidazole-2 Carboxamide Netropsin

Proceedings of the National Academy of Sciences - PNAS, 1992-08, Vol.89 (16), p.7586-7590

1992

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Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's A beta peptide

The Journal of biological chemistry, 1994-10, Vol.269 (41), p.25247-25250

1994

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Shikimate-derived metabolites. 11. A total synthesis of (.+-.)-chorismic acid

Journal of the American Chemical Society, 1982-12, Vol.104 (24), p.6787-6788

1982

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Binding Affinities of Tyrosine-phosphorylated Peptides to the COOH-terminal SH2 and NH2-terminal Phosphotyrosine Binding Domains of Shc (∗)

The Journal of biological chemistry, 1995-12, Vol.270 (52), p.31119-31123

1995

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Solution Structure of the Shc SH2 Domain Complexed with a Tyrosine-Phosphorylated Peptide from the T-Cell Receptor

Proceedings of the National Academy of Sciences - PNAS, 1995-08, Vol.92 (17), p.7784-7788

1995

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Exploring protein hotspots by optimized fragment pharmacophores

Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue

Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

Synthesis and structure–activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint

Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI)

Design of peptides that bind in the minor groove of DNA at 5'-(A,T)G(A,T)C(A,T)-3' sequences by a dimeric side-by-side motif

Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics

The Pineal Gland: Photoreception and Coupling of Behavioral, Metabolic, and Cardiovascular Circadian Outputs

Structure–activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability

Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2

Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1

Binding affinities of synthetic peptides, pyridine-2-carboxamidonetropsin and 1-methylimidazole-2-carboxamidonetropsin, that form 2:1 complexes in the minor groove of double-helical DNA

A high-throughput chemotaxis assay for pharmacological characterization of chemokine receptors: Utilization of U937 monocytic cells

The suprachiasmatic nucleus controls the circadian rhythm of heart rate via the sympathetic nervous system

Engineering metal coordination sites into the antibody light chain

Alteration of the sequence specificity of distamycin on DNA by replacement of an N-methylpyrrolecarboxamide with pyridine-2-carboxamide

Application of Base Cleavable Safety Catch Linkers to Solid Phase Library Production

Pinealectomized Rats Entrain and Phase-Shift to Melatonin Injections in a Dose-Dependent Manner

A highly specific metal-activated catalytic antibody

Antiparallel Side-by-Side Dimeric Motif for Sequence-Specific Recognition in the Minor Groove of DNA by the Designed Peptide 1-Methylimidazole-2 Carboxamide Netropsin

Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's A beta peptide

Shikimate-derived metabolites. 11. A total synthesis of (.+-.)-chorismic acid

Binding Affinities of Tyrosine-phosphorylated Peptides to the COOH-terminal SH2 and NH2-terminal Phosphotyrosine Binding Domains of Shc (∗)

Solution Structure of the Shc SH2 Domain Complexed with a Tyrosine-Phosphorylated Peptide from the T-Cell Receptor

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