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Kynurenines in the mammalian brain: when physiology meets pathology

Nature reviews. Neuroscience, 2012-07, Vol.13 (7), p.465-477

2012

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Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood

The European journal of neuroscience, 2012-05, Vol.35 (10), p.1605-1612

2012

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Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory

Neuropsychopharmacology (New York, N.Y.), 2011-10, Vol.36 (11), p.2357-2367

2011

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Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine

Psychopharmacologia, 2012-04, Vol.220 (3), p.627-637

2012

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Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior

Neuropsychopharmacology (New York, N.Y.), 2010-07, Vol.35 (8), p.1734-1742

2010

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Impaired Spatial Representation in CA1 after Lesion of Direct Input from Entorhinal Cortex

Neuron (Cambridge, Mass.), 2008-01, Vol.57 (2), p.290-302

2008

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The Astrocyte-Derived α7 Nicotinic Receptor Antagonist Kynurenic Acid Controls Extracellular Glutamate Levels in the Prefrontal Cortex

Journal of molecular neuroscience, 2010, Vol.40 (1-2), p.204-210

2010

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Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum

Journal of neurochemistry, 2005-05, Vol.93 (3), p.762-765

2005

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Increased cortical kynurenate content in schizophrenia

Biological psychiatry (1969), 2001-10, Vol.50 (7), p.521-530

2001

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Enzymatic transamination of d-kynurenine generates kynurenic acid in rat and human brain

Journal of neurochemistry, 2012-03, Vol.120 (6), p.1026-1035

2012

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Competitive Antagonism between the Nicotinic Allosteric Potentiating Ligand Galantamine and Kynurenic Acid at α7 Nicotinic Receptors

The Journal of pharmacology and experimental therapeutics, 2007-07, Vol.322 (1), p.48-58

2007

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The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition

The Journal of pharmacology and experimental therapeutics, 2015-10, Vol.355 (1), p.76

2015

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Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of (S)-4-(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor

ChemMedChem, 2006-05, Vol.1 (5), p.528-531

2006

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Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain

The Journal of biological chemistry, 2013-12, Vol.288 (51), p.36554-36566

2013

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Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid

Nature neuroscience, 2013-11, Vol.16 (11), p.1652-1661

2013

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Targeting Kynurenine Aminotransferase II in Psychiatric Diseases: Promising Effects of an Orally Active Enzyme Inhibitor

Schizophrenia bulletin, 2014-03, Vol.40 (Suppl 2), p.S152-S158

2014

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Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain

Analytical biochemistry, 2012-02, Vol.421 (2), p.573-581

2012

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Kynurenate and 7‐Chlorokynurenate Formation in Chronically Epileptic Rats

Epilepsia (Copenhagen), 2005-07, Vol.46 (7), p.1010-1016

2005

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Prolonged Nicotine Administration Results in Biphasic, Brain-Specific Changes in Kynurenate Levels in the Rat

Neuropsychopharmacology (New York, N.Y.), 2005-04, Vol.30 (4), p.697-704

2005

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Neuronal A1 receptors mediate increase in extracellular kynurenic acid after local intrastriatal adenosine infusion

Journal of neurochemistry, 2004-08, Vol.90 (3), p.621-628

2004

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On the comparison of price and quantity competition under endogenous timing

Research in economics, 2009-03, Vol.63 (1), p.55-61

2009

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2-oxoacids regulate kynurenic acid production in the rat brain : Studies in vitro and in vivo

Journal of neurochemistry, 1999-02, Vol.72 (2), p.643-651

1999

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Dopaminergic Control of Kynurenate Levels and N-Methyl-D-Aspartate Toxicity in the Developing Rat Striatum

Developmental neuroscience, 1998-03, Vol.20 (2-3), p.146-153

1998

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Kynurenic Acid in the Quinolinate-lesioned Rat Hippocampus: Studies In Vitro and In Vivo

The European journal of neuroscience, 1992, Vol.4 (12), p.1264-1270

1992

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Kynurenines in the mammalian brain: when physiology meets pathology

Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood

Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory

Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine

Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior

Impaired Spatial Representation in CA1 after Lesion of Direct Input from Entorhinal Cortex

The Astrocyte-Derived α7 Nicotinic Receptor Antagonist Kynurenic Acid Controls Extracellular Glutamate Levels in the Prefrontal Cortex

Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum

Increased cortical kynurenate content in schizophrenia

Enzymatic transamination of d-kynurenine generates kynurenic acid in rat and human brain

Competitive Antagonism between the Nicotinic Allosteric Potentiating Ligand Galantamine and Kynurenic Acid at α7 Nicotinic Receptors

The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of (S)-4-(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor

Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain

Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid

Targeting Kynurenine Aminotransferase II in Psychiatric Diseases: Promising Effects of an Orally Active Enzyme Inhibitor

Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain

Kynurenate and 7‐Chlorokynurenate Formation in Chronically Epileptic Rats

Prolonged Nicotine Administration Results in Biphasic, Brain-Specific Changes in Kynurenate Levels in the Rat

Neuronal A1 receptors mediate increase in extracellular kynurenic acid after local intrastriatal adenosine infusion

On the comparison of price and quantity competition under endogenous timing

2-oxoacids regulate kynurenic acid production in the rat brain : Studies in vitro and in vivo

Dopaminergic Control of Kynurenate Levels and N-Methyl-D-Aspartate Toxicity in the Developing Rat Striatum

Kynurenic Acid in the Quinolinate-lesioned Rat Hippocampus: Studies In Vitro and In Vivo

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