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A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma

Clinical cancer research, 2019-05, Vol.25 (9), p.2708-2716

2019

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Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers

Oncoimmunology, 2021-01, Vol.10 (1), p.1943253

2021

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Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1-Deficient Thoracic Cancers

Journal of clinical oncology, 2017-06, Vol.35 (16), p.1778-1785

2017

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Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

Investigational new drugs, 2013-04, Vol.31 (2), p.425-434

2013

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Dicaffeoylquinic and Dicaffeoyltartaric Acids Are Selective Inhibitors of Human Immunodeficiency Virus Type 1 Integrase

Antimicrobial Agents and Chemotherapy, 1998-01, Vol.42 (1), p.140-146

1998

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Structure-Based Design and Synthesis of Substituted 2-Butanols as Nonpeptidic Inhibitors of HIV Protease: Secondary Amide Series

Journal of medicinal chemistry, 1996-07, Vol.39 (14), p.2781-2794

1996

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Bis Tertiary Amide Inhibitors of the HIV-1 Protease Generated via Protein Structure-Based Iterative Design

Journal of medicinal chemistry, 1996-07, Vol.39 (14), p.2795-2811

1996

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Crystal-Structure-Based Design and Synthesis of Novel C-Terminal Inhibitors of HIV Protease

Journal of medicinal chemistry, 1994-07, Vol.37 (15), p.2274-2284

1994

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A phase II study of ADI-PEG 20 in combination with gemcitabine and docetaxel for the treatment of soft tissue sarcoma

Journal of clinical oncology, 2019-05, Vol.37 (15_suppl), p.TPS11079-TPS11079

2019

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A phase Ib study of ADI-PEG 20 plus pembrolizumab in advanced solid cancers

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.2556-2556

2018

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Phase 1 study of pegargiminase combined with cisplatin and pemetrexed in patients with ASS1-deficient uveal melanoma

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.2589-2589

2018

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Abstract B33: Expansion study of pegylated arginine deiminase (ADI-PEG20), pemetrexed, and cisplatin in patients with ASS1-deficient non-squamous non-small cell lung cancer (TRAP)

Clinical cancer research, 2018-09, Vol.24 (17_Supplement), p.B33-B33

2018

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Protein Structure-Based Design of Potent Orally Bioavailable, Nonpeptide Inhibitors of Human Immunodeficiency Virus Protease

Proceedings of the National Academy of Sciences - PNAS, 1995-04, Vol.92 (8), p.3298-3302

1995

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Highly purified pea chloroplast RNA polymerase transcribes both rRNA and mRNA genes

European journal of biochemistry, 1991-01, Vol.195 (1), p.215-228

1991

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A phase I expansion study of pegargiminase, cisplatin, and pemetrexed in argininosuccinate synthetase 1-negative recurrent high grade gliomas (HGGs)

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.e14085-e14085

2018

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18-FLT-PET/CT as an imaging biomarker in patients with ASS1-deficient thoracic cancers treated with ADI-PEG20, pemetrexed and cisplatin

Journal of clinical oncology, 2016-05, Vol.34 (15_suppl), p.11567-11567

2016

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A PHASE I EXPANSION STUDY OF PEGARGIMINASE, CISPLATIN AND PEMETREXED IN ARGININOSUCCINATE SYNTHETASE 1-NEGATIVE RECURRENT HIGH GRADE GLIOMAS (HGGS)

Neuro-oncology (Charlottesville, Va.), 2018-10, Vol.20 (suppl_5), p.v345-v345

2018

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Structure-based drug design of nonpeptidic P2 substituents for HIV-1 protease inhibitors

Bioorganic & medicinal chemistry letters, 1995-04, Vol.5 (7), p.727-732

1995

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ITERATIVE PROTEIN STRUCTURE-BASED DRUG DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS

European journal of medicinal chemistry, 1995, Vol.30, p.201s-214s

1995

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In vitro analysis of the pea chloroplast 16S rRNA gene promoter

Molecular and Cellular Biology, 1989-12, Vol.9 (12), p.5650-5659

1989

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Abstract 2702: Renal cell carcinomas lack arginosuccinate synthetase expression and respond to pegylated arginine deiminase treatment

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.2702-2702

2010

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Abstract 4519: Small cell lung cancers lack expression of argininosuccinate synthase (ASS) and are sensitive to arginine deprivation using arginine deiminase-PEG20 (ADI-PEG20)

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.4519-4519

2010

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Phase II study of ADI-PEG 20 in patients with relapsed sensitive or refractory small cell lung cancer

Journal of clinical oncology, 2012-05, Vol.30 (15_suppl), p.e17558-e17558

2012

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A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma

Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging

Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers

Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1-Deficient Thoracic Cancers

Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial

Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

Dicaffeoylquinic and Dicaffeoyltartaric Acids Are Selective Inhibitors of Human Immunodeficiency Virus Type 1 Integrase

Structure-Based Design and Synthesis of Substituted 2-Butanols as Nonpeptidic Inhibitors of HIV Protease: Secondary Amide Series

Bis Tertiary Amide Inhibitors of the HIV-1 Protease Generated via Protein Structure-Based Iterative Design

Crystal-Structure-Based Design and Synthesis of Novel C-Terminal Inhibitors of HIV Protease

A phase II study of ADI-PEG 20 in combination with gemcitabine and docetaxel for the treatment of soft tissue sarcoma

A phase Ib study of ADI-PEG 20 plus pembrolizumab in advanced solid cancers

Phase 1 study of pegargiminase combined with cisplatin and pemetrexed in patients with ASS1-deficient uveal melanoma

Abstract B33: Expansion study of pegylated arginine deiminase (ADI-PEG20), pemetrexed, and cisplatin in patients with ASS1-deficient non-squamous non-small cell lung cancer (TRAP)

Protein Structure-Based Design of Potent Orally Bioavailable, Nonpeptide Inhibitors of Human Immunodeficiency Virus Protease

Highly purified pea chloroplast RNA polymerase transcribes both rRNA and mRNA genes

A phase I expansion study of pegargiminase, cisplatin, and pemetrexed in argininosuccinate synthetase 1-negative recurrent high grade gliomas (HGGs)

18-FLT-PET/CT as an imaging biomarker in patients with ASS1-deficient thoracic cancers treated with ADI-PEG20, pemetrexed and cisplatin

A PHASE I EXPANSION STUDY OF PEGARGIMINASE, CISPLATIN AND PEMETREXED IN ARGININOSUCCINATE SYNTHETASE 1-NEGATIVE RECURRENT HIGH GRADE GLIOMAS (HGGS)

Structure-based drug design of nonpeptidic P2 substituents for HIV-1 protease inhibitors

ITERATIVE PROTEIN STRUCTURE-BASED DRUG DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS

In vitro analysis of the pea chloroplast 16S rRNA gene promoter

Abstract 2702: Renal cell carcinomas lack arginosuccinate synthetase expression and respond to pegylated arginine deiminase treatment

Abstract 4519: Small cell lung cancers lack expression of argininosuccinate synthase (ASS) and are sensitive to arginine deprivation using arginine deiminase-PEG20 (ADI-PEG20)

Phase II study of ADI-PEG 20 in patients with relapsed sensitive or refractory small cell lung cancer

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