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The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits

The Journal of pharmacology and experimental therapeutics, 2016-07, Vol.358 (1), p.71-82

2016

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Allosteric modulation of the muscarinic M₄ receptor as an approach to treating schizophrenia

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (31), p.10978-10983

2008

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A role for cannabinoid CB1 receptors in mood and anxiety disorders

Behavioural pharmacology, 2005-09, Vol.16 (5-6), p.315-331

2005

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Preclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability-related effects

Pharmacology, biochemistry and behavior, 2017-04, Vol.155, p.43-55

2017

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Procholinergic and memory enhancing properties of the selective norepinephrine uptake inhibitor atomoxetine

Molecular psychiatry, 2006-02, Vol.11 (2), p.187-195

2006

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Obituary: J. David LEander, Ph.D. : (April 8, 1944-November 14, 2014)

Psychopharmacology, 2015-04, Vol.232 (7), p.1175-1176

2015

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In vivo occupancy of dopamine D3 receptors by antagonists produces neurochemical and behavioral effects of potential relevance to attention-deficit-hyperactivity disorder

The Journal of pharmacology and experimental therapeutics, 2013-02, Vol.344 (2), p.501

2013

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The α2,3-selective potentiators of GABAA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects and block chemotherapy-induced hyperalgesia in mice without tolerance development

Pharmacology, biochemistry and behavior, 2020-09, Vol.196, p.172996-172996, Article 172996

2020

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M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine

The Journal of pharmacology and experimental therapeutics, 2014-11, Vol.351 (2), p.448

2014

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AMPA receptor potentiators as novel antidepressants

Current pharmaceutical design, 2005-01, Vol.11 (12), p.1511-1527

2005

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Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N -Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression

The Journal of pharmacology and experimental therapeutics, 2017-04, Vol.361 (1), p.68-86

2017

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Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the central nervous system

Pharmacology & therapeutics (Oxford), 2004-07, Vol.103 (1), p.1-20

2004

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Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA A receptors: Improved bioavailability enhances anticonvulsant efficacy

Neuropharmacology, 2018-07, Vol.137, p.332

2018

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Perampanel, an antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, for the treatment of epilepsy: studies in human epileptic brain and nonepileptic brain and in rodent models

The Journal of pharmacology and experimental therapeutics, 2014-10, Vol.351 (1), p.124-133

2014

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The α2,3-selective potentiator of GABA A receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

Pharmacology, biochemistry and behavior, 2019-05, Vol.180, p.22

2019

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Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors

Pharmacology, biochemistry and behavior, 2017-06, Vol.157, p.35-40

2017

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An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA A receptors

Pharmacology, biochemistry and behavior, 2018-07, Vol.170, p.9-13

2018

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The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

Pharmacology, biochemistry and behavior, 2019-05, Vol.180, p.22-31

2019

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Behavioral effects and anticonvulsant efficacies of low-affinity, uncompetitive NMDA antagonists in mice

Psychopharmacologia, 1999-10, Vol.146 (3), p.280-289

1999

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Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate

Neuropharmacology, 2000-06, Vol.39 (7), p.1184-1196

2000

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mGlu2/3 agonist-induced hyperthermia: an in vivo assay for detection of mGlu2/3 receptor antagonism and its relation to antidepressant-like efficacy in mice

CNS & neurological disorders drug targets, 2013-08, Vol.12 (5), p.554-566

2013

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Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections

The Journal of pharmacology and experimental therapeutics, 1991-05, Vol.257 (2), p.706

1991

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Pharmacological and behavioral characterization of cocaine-kindled seizures in mice

Psychopharmacologia, 2000-01, Vol.148 (1), p.74-82

2000

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Obituary: J. David Leander, Ph.D: April 8, 1944–November 14, 2014

Psychopharmacology, 2015-04, Vol.232 (7), p.1175-1176

2015

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Pharmacological characterization of the novel discriminative stimulus effects of a low dose of cocaine

The Journal of pharmacology and experimental therapeutics, 1994-09, Vol.270 (3), p.1041

1994

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The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits

Allosteric modulation of the muscarinic M₄ receptor as an approach to treating schizophrenia

A role for cannabinoid CB1 receptors in mood and anxiety disorders

Preclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability-related effects

Procholinergic and memory enhancing properties of the selective norepinephrine uptake inhibitor atomoxetine

Obituary: J. David LEander, Ph.D. : (April 8, 1944-November 14, 2014)

In vivo occupancy of dopamine D3 receptors by antagonists produces neurochemical and behavioral effects of potential relevance to attention-deficit-hyperactivity disorder

The α2,3-selective potentiators of GABAA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects and block chemotherapy-induced hyperalgesia in mice without tolerance development

M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine

AMPA receptor potentiators as novel antidepressants

Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N -Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression

Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the central nervous system

Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA A receptors: Improved bioavailability enhances anticonvulsant efficacy

Perampanel, an antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, for the treatment of epilepsy: studies in human epileptic brain and nonepileptic brain and in rodent models

The α2,3-selective potentiator of GABA A receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors

An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA A receptors

The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

Behavioral effects and anticonvulsant efficacies of low-affinity, uncompetitive NMDA antagonists in mice

Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate

mGlu2/3 agonist-induced hyperthermia: an in vivo assay for detection of mGlu2/3 receptor antagonism and its relation to antidepressant-like efficacy in mice

Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections

Pharmacological and behavioral characterization of cocaine-kindled seizures in mice

Obituary: J. David Leander, Ph.D: April 8, 1944–November 14, 2014

Pharmacological characterization of the novel discriminative stimulus effects of a low dose of cocaine

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