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Caenorhabditis elegans SID-2 is required for environmental RNA interference

Proceedings of the National Academy of Sciences - PNAS, 2007-06, Vol.104 (25), p.10565-10570

2007

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GP369, an FGFR2-IIIb-Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling

Cancer research (Chicago, Ill.), 2010-10, Vol.70 (19), p.7630-7639

2010

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Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody

Cancer treatment and research communications, 2021, Vol.28, p.100433-100433, Article 100433

2021

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Systemic RNAi in C. elegans Requires the Putative Transmembrane Protein SID-1

Science (American Association for the Advancement of Science), 2002-03, Vol.295 (5564), p.2456-2459

2002

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Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression

Cancer immunology research, 2022-05, Vol.10 (5), p.581-596

2022

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Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models

Clinical cancer research, 2015-03, Vol.21 (5), p.1106-1114

2015

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mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity

Cancer immunology research, 2023-07, Vol.11 (7), p.962-977

2023

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1059 Spatial analysis of tumor infiltrating lymphocyte populations in syngeneic mouse tumor models after treatment with IL-12 (mWTX-330) and IL-2 (WTX-124) INDUKINETM molecules

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1166-A1166

2023

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1075 Development of WTX-712, a conditionally active IL-21 INDUKINETM molecule for the treatment of cancer

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1184-A1184

2023

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1058 Optimal antitumor immunity triggered by WTX-124, a clinical stage conditionally activated INDUKINETM molecule that releases fully potent IL-2 in the tumor microenvironment

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1165-A1165

2023

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252 The combination of ACT and INDUKINE therapy leads to improved antitumor immunity in solid tumors

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A291-A291

2023

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23814, an Inhibitory Antibody of Ligand-Mediated Notch1 Activation, Modulates Angiogenesis and Inhibits Tumor Growth without Gastrointestinal Toxicity

Molecular cancer therapeutics, 2015-08, Vol.14 (8), p.1858-1867

2015

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Abstract 1829: Generation of IL-21 INDUKINETM molecules for the treatment of cancer

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1829-1829

2023

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Abstract 4078: WTX-712, a conditionally active IL-21 INDUKINETM molecule, induces a strong anti-tumor phenotype through a differentiated mechanism

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.4078-4078

2024

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Abstract 1817: WTX-613, (JZP898) a selectively activated IFNα INDUKINE™ molecule, reprograms the tumor microenvironment and generates robust anti-tumor immunity as a monotherapy and in combination with checkpoint inhibitors

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1817-1817

2023

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Abstract A074: Discovery of WTX-330, a clinical stage conditionally activated IL-12 INDUKINETM therapeutic with potent antitumor activity in murine syngeneic tumor models resistant to checkpoint blockade

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.A074-A074

2023

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Abstract 4074: Discovery of WTX-518, an IL-18 pro-drug that is conditionally activated within the tumor microenvironment and induces regressions in mouse tumor models

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.4074-4074

2024

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Abstract 2054: WTX-124 is a novel IL-2 pro-drug that is conditionally activated in tumors and drives anti-tumor immunity by activating tumor infiltrating CD8+ T cells

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2054-2054

2022

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Abstract 2055: WTX-330 is a conditionally activated IL-12 prodrug that fundamentally reprograms tumor infiltrating CD8+ T cells and drives tumor regression

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2055-2055

2022

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Abstract 4586: Essential role of fibroblast growth factor receptor 2 (FGFR2) in tumorigenesis of human cancers with activated FGFR2 signaling demonstrated by functional blocking antibodies

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.4586-4586

2011

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Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment

PloS one, 2017-07, Vol.12 (7), p.e0181779

2017

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High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2

Molecular cell, 2019-08, Vol.75 (4), p.741-755.e11

2019

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Organization of the human intestine at single-cell resolution

Nature (London), 2023-07, Vol.619 (7970), p.572-584

2023

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Maintenance measures for preservation and recovery of permeable pavement surface infiltration rate – The effects of street sweeping, vacuum cleaning, high pressure washing, and milling

Journal of environmental management, 2016-03, Vol.169, p.132-144

2016

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Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer

Nature genetics, 2022-07, Vol.54 (7), p.985-995

2022

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Caenorhabditis elegans SID-2 is required for environmental RNA interference

GP369, an FGFR2-IIIb-Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling

Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody

Systemic RNAi in C. elegans Requires the Putative Transmembrane Protein SID-1

Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression

Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models

mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity

1059 Spatial analysis of tumor infiltrating lymphocyte populations in syngeneic mouse tumor models after treatment with IL-12 (mWTX-330) and IL-2 (WTX-124) INDUKINETM molecules

1075 Development of WTX-712, a conditionally active IL-21 INDUKINETM molecule for the treatment of cancer

1058 Optimal antitumor immunity triggered by WTX-124, a clinical stage conditionally activated INDUKINETM molecule that releases fully potent IL-2 in the tumor microenvironment

252 The combination of ACT and INDUKINE therapy leads to improved antitumor immunity in solid tumors

23814, an Inhibitory Antibody of Ligand-Mediated Notch1 Activation, Modulates Angiogenesis and Inhibits Tumor Growth without Gastrointestinal Toxicity

Abstract 1829: Generation of IL-21 INDUKINETM molecules for the treatment of cancer

Abstract 4078: WTX-712, a conditionally active IL-21 INDUKINETM molecule, induces a strong anti-tumor phenotype through a differentiated mechanism

Abstract 1817: WTX-613, (JZP898) a selectively activated IFNα INDUKINE™ molecule, reprograms the tumor microenvironment and generates robust anti-tumor immunity as a monotherapy and in combination with checkpoint inhibitors

Abstract A074: Discovery of WTX-330, a clinical stage conditionally activated IL-12 INDUKINETM therapeutic with potent antitumor activity in murine syngeneic tumor models resistant to checkpoint blockade

Abstract 4074: Discovery of WTX-518, an IL-18 pro-drug that is conditionally activated within the tumor microenvironment and induces regressions in mouse tumor models

Abstract 2054: WTX-124 is a novel IL-2 pro-drug that is conditionally activated in tumors and drives anti-tumor immunity by activating tumor infiltrating CD8+ T cells

Abstract 2055: WTX-330 is a conditionally activated IL-12 prodrug that fundamentally reprograms tumor infiltrating CD8+ T cells and drives tumor regression

Abstract 4586: Essential role of fibroblast growth factor receptor 2 (FGFR2) in tumorigenesis of human cancers with activated FGFR2 signaling demonstrated by functional blocking antibodies

Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment

High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2

Organization of the human intestine at single-cell resolution

Maintenance measures for preservation and recovery of permeable pavement surface infiltration rate – The effects of street sweeping, vacuum cleaning, high pressure washing, and milling

Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer

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