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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Proceedings of the National Academy of Sciences - PNAS, 2016-06, Vol.113 (26), p.7124-7129

2016

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Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.583-598

2018

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Recent advances in the evolutionary engineering of industrial biocatalysts

Genomics (San Diego, Calif.), 2014-12, Vol.104 (6), p.406-411

2014

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Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor

Clinical cancer research, 2007-03, Vol.13 (5), p.1576-1583

2007

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Targeted protein degradation by PROTACs

Pharmacology & therapeutics (Oxford), 2017-06, Vol.174, p.138-144

2017

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Refactoring the Genetic Code for Increased Evolvability

mBio, 2017-11, Vol.8 (6)

2017

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Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

Chemistry & biology, 2015-06, Vol.22 (6), p.755-763

2015

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The LASER database: Formalizing design rules for metabolic engineering

Metabolic engineering communications, 2015-12, Vol.2 (C), p.30-38

2015

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Evolved osmotolerant Escherichia coli mutants frequently exhibit defective N-acetylglucosamine catabolism and point mutations in cell shape-regulating protein MreB

Applied and Environmental Microbiology, 2014-06, Vol.80 (12), p.3729-3740

2014

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

Oncogene, 1999-07, Vol.18 (28), p.4047-4054

1999

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Bacterial Recombineering: Genome Engineering via Phage-Based Homologous Recombination

ACS synthetic biology, 2015-11, Vol.4 (11), p.1176-1185

2015

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Quantifying complexity in metabolic engineering using the LASER database

Metabolic engineering communications, 2016-12, Vol.3 (C), p.227-233

2016

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Clinical experience of MEK inhibitors in cancer therapy

Biochimica et biophysica acta, 2007-08, Vol.1773 (8), p.1248-1255

2007

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Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7

Journal of medicinal chemistry, 2001-06, Vol.44 (12), p.2015-2026

2001

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Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors

Molecular cancer therapeutics, 2022-03, Vol.21 (3), p.397-406

2022

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Complex systems in metabolic engineering

Current opinion in biotechnology, 2015-12, Vol.36 (C), p.107-114

2015

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Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts

Journal of rheumatology, 2002-02, Vol.29 (2), p.230

2002

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The Tolerome: A Database of Transcriptome-Level Contributions to Diverse Escherichia coli Resistance and Tolerance Phenotypes

ACS synthetic biology, 2017-12, Vol.6 (12), p.2302-2315

2017

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The emergence of commodity-scale genetic manipulation

Current opinion in chemical biology, 2015-10, Vol.28, p.150-155

2015

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4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo

Journal of medicinal chemistry, 2005-09, Vol.48 (18), p.5644-5647

2005

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A Web Interface for Codon Compression

ACS synthetic biology, 2016-09, Vol.5 (9), p.1021-1023

2016

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The Resistome: A Comprehensive Database of Escherichia coli Resistance Phenotypes

ACS synthetic biology, 2016-12, Vol.5 (12), p.1566-1577

2016

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An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage

Cancer research (Chicago, Ill.), 2000-02, Vol.60 (3), p.566-572

2000

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Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity

The Journal of biological chemistry, 2000-04, Vol.275 (14), p.10342-10348

2000

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Genome-Wide Tuning of Protein Expression Levels to Rapidly Engineer Microbial Traits

ACS synthetic biology, 2015-11, Vol.4 (11), p.1244-1253

2015

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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1

Recent advances in the evolutionary engineering of industrial biocatalysts

Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor

Targeted protein degradation by PROTACs

Refactoring the Genetic Code for Increased Evolvability

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

The LASER database: Formalizing design rules for metabolic engineering

Evolved osmotolerant Escherichia coli mutants frequently exhibit defective N-acetylglucosamine catabolism and point mutations in cell shape-regulating protein MreB

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

Bacterial Recombineering: Genome Engineering via Phage-Based Homologous Recombination

Quantifying complexity in metabolic engineering using the LASER database

Clinical experience of MEK inhibitors in cancer therapy

Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7

Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors

Complex systems in metabolic engineering

Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts

The Tolerome: A Database of Transcriptome-Level Contributions to Diverse Escherichia coli Resistance and Tolerance Phenotypes

The emergence of commodity-scale genetic manipulation

4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo

A Web Interface for Codon Compression

The Resistome: A Comprehensive Database of Escherichia coli Resistance Phenotypes

An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage

Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity

Genome-Wide Tuning of Protein Expression Levels to Rapidly Engineer Microbial Traits

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