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Prodrugs of phosphonates and phosphates: crossing the membrane barrier

Topics in current chemistry, 2015-01, Vol.360, p.115

2015

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Mixed Aryl Phosphonate Prodrugs of a Butyrophilin Ligand

ACS medicinal chemistry letters, 2017-09, Vol.8 (9), p.914-918

2017

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Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors

Molecules (Basel, Switzerland), 2017-05, Vol.22 (6), p.886

2017

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Direct Conversion of Benzylic and Allylic Alcohols to Phosphonates

Journal of organic chemistry, 2011-04, Vol.76 (8), p.2875-2879

2011

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Isoprenoid metabolism as a therapeutic target in gram-negative pathogens

Current topics in medicinal chemistry, 2010-12, Vol.10 (18), p.1858-1871

2010

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The intermediate enzymes of isoprenoid metabolism as anticancer targets

Anti-cancer agents in medicinal chemistry, 2009-06, Vol.9 (5), p.526-542

2009

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Total Synthesis of (+)-Schweinfurthins B and E

Journal of organic chemistry, 2009-09, Vol.74 (18), p.6965-6972

2009

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Exploration of Cascade Cyclizations Terminated by Tandem Aromatic Substitution: Total Synthesis of (+)-Schweinfurthin A

Journal of organic chemistry, 2011-02, Vol.76 (3), p.909-919

2011

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Diester Prodrugs of a Phosphonate Butyrophilin Ligand Display Improved Cell Potency, Plasma Stability, and Payload Internalization

Journal of medicinal chemistry, 2023-11, Vol.66 (22), p.15309-15325

2023

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3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines

Lipids, 2015-12, Vol.50 (12), p.1195-1207

2015

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A Tandem Cascade Cyclization−Electrophilic Aromatic Substitution: Application in the Total Synthesis of (+)-Angelichalcone

Journal of the American Chemical Society, 2009-10, Vol.131 (41), p.14630-14631

2009

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Substitution of a triazole for the central olefin in biologically active stilbenes

Bioorganic & medicinal chemistry letters, 2022-11, Vol.75, p.128980-128980, Article 128980

2022

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Conjugate reduction of vinyl bisphosphonates

Tetrahedron letters, 2022-09, Vol.106, p.154078, Article 154078

2022

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A luciferase lysis assay reveals in vivo malignant cell sensitization by phosphoantigen prodrugs

Biochemical pharmacology, 2019-12, Vol.170, p.113668-113668, Article 113668

2019

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Efficiency of bis-amidate phosphonate prodrugs

Bioorganic & medicinal chemistry letters, 2022-06, Vol.66, p.128724-128724, Article 128724

2022

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Enhanced Plasma Stability and Potency of Aryl/Acyloxy Prodrugs of a BTN3A1 Ligand

ACS medicinal chemistry letters, 2024-10, Vol.15 (10), p.1771-1777

2024

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Synthesis of isoprenoid bisphosphonate ethers through C-P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase

Beilstein journal of organic chemistry, 2014-07, Vol.10 (1), p.1645-1650

2014

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Opportunities and challenges in development of phosphoantigens as Vγ9Vδ2 T cell agonists

Biochemical pharmacology, 2014-06, Vol.89 (3), p.301-312

2014

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A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro[S]

Journal of lipid research, 2011-11, Vol.52 (11), p.1957-1964

2011

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Synthesis of a Coumarin-Based Analogue of Schweinfurthin F

Journal of organic chemistry, 2021-12, Vol.86 (23), p.16824-16833

2021

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Potent double prodrug forms of synthetic phosphoantigens

Bioorganic & medicinal chemistry, 2020-10, Vol.28 (19), p.115666-115666, Article 115666

2020

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Synthesis of Nonracemic 3-Deoxyschweinfurthin B

Journal of organic chemistry, 2005-02, Vol.70 (3), p.925-931

2005

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Functional evaluation of a fluorescent schweinfurthin: mechanism of cytotoxicity and intracellular quantification

Molecular pharmacology, 2012-07, Vol.82 (1), p.9-16

2012

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α-Amino bisphosphonate triazoles serve as GGDPS inhibitors

Bioorganic & medicinal chemistry letters, 2024-04, Vol.102, p.129659-129659, Article 129659

2024

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Incorporation of a FRET pair within a phosphonate diester

Bioorganic chemistry, 2021-09, Vol.114, p.105048-105048, Article 105048

2021

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Prodrugs of phosphonates and phosphates: crossing the membrane barrier

Mixed Aryl Phosphonate Prodrugs of a Butyrophilin Ligand

Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors

Direct Conversion of Benzylic and Allylic Alcohols to Phosphonates

Isoprenoid metabolism as a therapeutic target in gram-negative pathogens

The intermediate enzymes of isoprenoid metabolism as anticancer targets

Total Synthesis of (+)-Schweinfurthins B and E

Exploration of Cascade Cyclizations Terminated by Tandem Aromatic Substitution: Total Synthesis of (+)-Schweinfurthin A

Diester Prodrugs of a Phosphonate Butyrophilin Ligand Display Improved Cell Potency, Plasma Stability, and Payload Internalization

3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines

A Tandem Cascade Cyclization−Electrophilic Aromatic Substitution: Application in the Total Synthesis of (+)-Angelichalcone

Substitution of a triazole for the central olefin in biologically active stilbenes

Conjugate reduction of vinyl bisphosphonates

A luciferase lysis assay reveals in vivo malignant cell sensitization by phosphoantigen prodrugs

Efficiency of bis-amidate phosphonate prodrugs

Enhanced Plasma Stability and Potency of Aryl/Acyloxy Prodrugs of a BTN3A1 Ligand

Synthesis of isoprenoid bisphosphonate ethers through C-P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase

Opportunities and challenges in development of phosphoantigens as Vγ9Vδ2 T cell agonists

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro[S]

Synthesis of a Coumarin-Based Analogue of Schweinfurthin F

Potent double prodrug forms of synthetic phosphoantigens

Synthesis of Nonracemic 3-Deoxyschweinfurthin B

Functional evaluation of a fluorescent schweinfurthin: mechanism of cytotoxicity and intracellular quantification

α-Amino bisphosphonate triazoles serve as GGDPS inhibitors

Incorporation of a FRET pair within a phosphonate diester

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