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Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor

Clinical cancer research, 2022-02, Vol.28 (4), p.770-780

2022

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Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases

Journal of medicinal chemistry, 2015-02, Vol.58 (3), p.1358-1371

2015

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Activity and resistance of a brain-permeable paradox breaker BRAF inhibitor in melanoma brain metastasis

Cancer research (Chicago, Ill.), 2022-07, Vol.82 (14), p.2552-2564

2022

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Behavioral Effects of a Synthetic Agonist Selective for Nociceptin Orphanin FQ Peptide Receptors in Monkeys

Neuropsychopharmacology (New York, N.Y.), 2009-08, Vol.34 (9), p.2088-2096

2009

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The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys

Psychopharmacologia, 2011-01, Vol.213 (1), p.53-60

2011

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Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1666-1669

2009

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Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma

Molecular therapy. Oncolytics, 2021-03, Vol.20, p.166-174

2021

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Positive Allosteric Modulators of Metabotropic Glutamate 1 Receptor: Characterization, Mechanism of Action, and Binding Site

Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (23), p.13402-13407

2001

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Activation of Nociceptin Orphanin FQ Peptide Receptors Disrupts Visual but Not Auditory Sensorimotor Gating in BALB cByJ Mice: Comparison to Dopamine Receptor Agonists

Neuropsychopharmacology, 2012-01, Vol.37 (2), p.378-389

2012

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Altered distribution of mGlu2 receptors in β-amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice

Brain research, 2010-12, Vol.1363, p.180-190

2010

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Education and the values crisis in Central and Eastern Europe

1994

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Distribution and abundance of metabotropic glutamate receptor subtype 2 in rat brain revealed by [3H]LY354740 binding in vitro and quantitative radioautography: Correlation with the sites of synthesis, expression, and agonist stimulation of [35S]GTPγs binding

Journal of comparative neurology (1911), 2005-06, Vol.487 (1), p.15-27

2005

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Further characterization of the prototypical nociceptin/orphanin FQ peptide receptor agonist Ro 64-6198 in rodent models of conflict anxiety and despair

Psychopharmacologia, 2012-07, Vol.222 (2), p.203-214

2012

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Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5746-5752

2009

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Sehen, um zu glauben: Frühsowjetische Kunstwerke im Prozess der politisch-moralischen Erziehung und gesellschaftlichen Integration der "Massen"

Wichmann, Jürgen

2001

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Nociceptin Receptor Impairs Recognition Memory via Interaction with NMDA Receptor-Dependent Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in the Hippocampus

The Journal of neuroscience, 2008-02, Vol.28 (9), p.2190-2198

2008

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High-Affinity, Non-Peptide Agonists for the ORL1 (Orphanin FQ/Nociceptin) Receptor

Journal of medicinal chemistry, 2000-04, Vol.43 (7), p.1329-1338

2000

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Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity

The Journal of pharmacology and experimental therapeutics, 2005-11, Vol.315 (2), p.711-721

2005

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A Short and Efficient Synthesis of (2S,2′R,3′R)-2-(2′,3′-Dicarboxylcyclopropyl)glycine (DCG-IV)

European journal of organic chemistry, 1999-11, Vol.1999 (11), p.3131-3133

1999

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Characterization of the Discriminative Stimulus Effects of a NOP Receptor Agonist Ro 64-6198 in Rhesus Monkeys

The Journal of pharmacology and experimental therapeutics, 2016-04, Vol.357 (1), p.17-23

2016

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Natalija Mussijenko / Alexander Vatlin, Schule der Träume: Die Karl-Liebknecht-Schule in Moskau (1924 - 1938), Bad Heilbrunn, Klinkhardt, 2005, 484 S., ISBN 3-7815-1368-8. [Rezension]

Erziehungswissenschaftliche revue, 2006, Vol.5 (2), p.5:2

Wichmann, Jürgen

2006

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Natalija Mussijenko / Alexander Vatlin: Schule der Träume. Die Karl-Liebknecht-Schule in Moskau (1924-1938). Bad Heilbrunn: Klinkhardt 2005 (484 S.) [Rezension]

Erziehungswissenschaftliche revue, 2006, Vol.5 (2), p.5:2

Wichmann, Jürgen

2006

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Synthesis and characterization of 1,3-dihydro-benzo[ b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.6969-6974

2010

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ORL1 receptor ligands : Structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-ones

Bioorganic & medicinal chemistry letters, 2000-04, Vol.10 (8), p.831-834

2000

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The effect of a systemically active ORL-1 agonist, Ro 64-6198, on the acquisition, expression, extinction, and reinstatement of morphine conditioned place preference

Neuropharmacology, 2005-09, Vol.49 (4), p.439-446

2005

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Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases

Activity and resistance of a brain-permeable paradox breaker BRAF inhibitor in melanoma brain metastasis

Behavioral Effects of a Synthetic Agonist Selective for Nociceptin Orphanin FQ Peptide Receptors in Monkeys

The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys

Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers

Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma

Positive Allosteric Modulators of Metabotropic Glutamate 1 Receptor: Characterization, Mechanism of Action, and Binding Site

Activation of Nociceptin Orphanin FQ Peptide Receptors Disrupts Visual but Not Auditory Sensorimotor Gating in BALB cByJ Mice: Comparison to Dopamine Receptor Agonists

Altered distribution of mGlu2 receptors in β-amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice

Education and the values crisis in Central and Eastern Europe

Distribution and abundance of metabotropic glutamate receptor subtype 2 in rat brain revealed by [3H]LY354740 binding in vitro and quantitative radioautography: Correlation with the sites of synthesis, expression, and agonist stimulation of [35S]GTPγs binding

Further characterization of the prototypical nociceptin/orphanin FQ peptide receptor agonist Ro 64-6198 in rodent models of conflict anxiety and despair

Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series

Sehen, um zu glauben: Frühsowjetische Kunstwerke im Prozess der politisch-moralischen Erziehung und gesellschaftlichen Integration der "Massen"

Nociceptin Receptor Impairs Recognition Memory via Interaction with NMDA Receptor-Dependent Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in the Hippocampus

High-Affinity, Non-Peptide Agonists for the ORL1 (Orphanin FQ/Nociceptin) Receptor

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity

A Short and Efficient Synthesis of (2S,2′R,3′R)-2-(2′,3′-Dicarboxylcyclopropyl)glycine (DCG-IV)

Characterization of the Discriminative Stimulus Effects of a NOP Receptor Agonist Ro 64-6198 in Rhesus Monkeys

Natalija Mussijenko / Alexander Vatlin, Schule der Träume: Die Karl-Liebknecht-Schule in Moskau (1924 - 1938), Bad Heilbrunn, Klinkhardt, 2005, 484 S., ISBN 3-7815-1368-8. [Rezension]

Natalija Mussijenko / Alexander Vatlin: Schule der Träume. Die Karl-Liebknecht-Schule in Moskau (1924-1938). Bad Heilbrunn: Klinkhardt 2005 (484 S.) [Rezension]

Synthesis and characterization of 1,3-dihydro-benzo[ b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

ORL1 receptor ligands : Structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-ones

The effect of a systemically active ORL-1 agonist, Ro 64-6198, on the acquisition, expression, extinction, and reinstatement of morphine conditioned place preference

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