UB Paderborn / Katalog / Suche / in CDI

1 – 25 von 99

Sortiert nach

Novel synthetic and computational approaches to the discovery of drugs targeting nonalcoholic fatty liver disease

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S6-S7

Westlin, William

2019

Link zum Volltext

Verfügbarkeit prüfen

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (13), p.E1796-E1805

2016

Link zum Volltext

Verfügbarkeit prüfen

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

Nature medicine, 2016-10, Vol.22 (10), p.1108-1119

2016

Link zum Volltext

Verfügbarkeit prüfen

Acetyl‐coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double‐blind, crossover study

Hepatology (Baltimore, Md.), 2017-08, Vol.66 (2), p.324-334

2017

Link zum Volltext

Verfügbarkeit prüfen

Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy

The Journal of experimental medicine, 2015-12, Vol.212 (13), p.2189-2201

2015

Link zum Volltext

Verfügbarkeit prüfen

Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans

The Journal of pharmacology and experimental therapeutics, 2013-08, Vol.346 (2), p.219

2013

Link zum Volltext

Verfügbarkeit prüfen

Kidney transplantation from triple‐knockout pigs expressing multiple human proteins in cynomolgus macaques

American journal of transplantation, 2022-01, Vol.22 (1), p.46-57

2022

Link zum Volltext

Verfügbarkeit prüfen

MYD88 L265P mutations identify a prognostic gene expression signature and a pathway for targeted inhibition in CLL

British journal of haematology, 2019-03, Vol.184 (6), p.925-936

2019

Link zum Volltext

Verfügbarkeit prüfen

Extensive germline genome engineering in pigs

Nature biomedical engineering, 2021-02, Vol.5 (2), p.134

2021

Link zum Volltext

Verfügbarkeit prüfen

Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine

Nature chemical biology, 2011-01, Vol.7 (1), p.22

2011

Link zum Volltext

Verfügbarkeit prüfen

In vitro and in vivo characterization of irreversible mutant-selective EGFR inhibitors that are wild-type sparing

Molecular cancer therapeutics, 2014-06, Vol.13 (6), p.1468-1479

2014

Link zum Volltext

Verfügbarkeit prüfen

Genetic modifications designed for xenotransplantation attenuate sialoadhesin‐dependent binding of human erythrocytes to porcine macrophages

Xenotransplantation (Københaven), 2022-11, Vol.29 (6), p.e12780-n/a

2022

Link zum Volltext

Verfügbarkeit prüfen

Abstract 1048: Modulation of lipid metabolism through inhibition of acetyl-CoA carboxylase with ND-646 leads to potent inhibition of breast cancer cell growth in vitro and in vivo

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1048-1048

2016

Link zum Volltext

Verfügbarkeit prüfen

A Methionine Aminopeptidase-2 Inhibitor, PPI-2458, for the Treatment of Rheumatoid Arthritis

Proceedings of the National Academy of Sciences - PNAS, 2004-07, Vol.101 (29), p.10768-10773

2004

Link zum Volltext

Verfügbarkeit prüfen

αvβ3 Integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice

Cancer research (Chicago, Ill.), 2003-05, Vol.63 (9), p.2079-2087

2003

Link zum Volltext

Verfügbarkeit prüfen

Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis

ACS medicinal chemistry letters, 2013-10, Vol.4 (10), p.942-947

2013

Link zum Volltext

Verfügbarkeit prüfen

Methionine aminopeptidases type I and type II are essential to control cell proliferation

Journal of cellular biochemistry, 2005-08, Vol.95 (6), p.1191-1203

2005

Link zum Volltext

Verfügbarkeit prüfen

Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (2), p.472-475

2013

Link zum Volltext

Verfügbarkeit prüfen

Liver Selective Acetyl-CoA Carboxylase Inhibition Inhibits Hepatocellular Carcinoma in a Cirrhosis Model

Journal of the American College of Surgeons, 2014-09, Vol.219 (3), p.S23-S24

2014

Link zum Volltext

Verfügbarkeit prüfen

Leukocyte Adhesion to Vascular Endothelium Induces E-Selectin Linkage to the Actin Cytoskeleton

The Journal of cell biology, 1996-04, Vol.133 (2), p.445-455

1996

Link zum Volltext

Verfügbarkeit prüfen

Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3156-3161

2006

Link zum Volltext

Verfügbarkeit prüfen

TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis

The Journal of clinical investigation, 2020-04, Vol.130 (4), p.1863-1878

2020

Link zum Volltext

Verfügbarkeit prüfen

Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2520-2524

2010

Link zum Volltext

Verfügbarkeit prüfen

1 – 25 von 99

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(95)
Mit Volltextzugriff
(90)

Publikationsform

Artikel
(98)
Dissertationen
(1)

Sprache

Englisch
(99)
Japanisch
(12)

Erscheinungsjahr

n.n

Thema

Science & Technology
(46)
Life Sciences & Biomedicine
(42)
Humans
(36)
Animals
(33)
Biological And Medical Sciences
(18)
Mice
(17)
Pharmacology & Pharmacy
(16)
Male
(14)
Medical Sciences
(14)
Chemistry, Medicinal
(10)
Pharmacology. Drug Treatments
(10)
Female
(9)
Structure-Activity Relationship
(9)
Aminopeptidases - Antagonists & Inhibitors
(7)
Rats
(7)
Administration, Oral
(6)
Cell Biology
(6)
Cell Line
(6)
Cell Proliferation - Drug Effects
(6)
Cells, Cultured
(6)

15 weitere anzeigen...

Weniger anzeigen...

Menü

Weitere Dienste

Einstellungen

Novel synthetic and computational approaches to the discovery of drugs targeting nonalcoholic fatty liver disease

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

Acetyl‐coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double‐blind, crossover study

Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans

Kidney transplantation from triple‐knockout pigs expressing multiple human proteins in cynomolgus macaques

MYD88 L265P mutations identify a prognostic gene expression signature and a pathway for targeted inhibition in CLL

Extensive germline genome engineering in pigs

Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine

In vitro and in vivo characterization of irreversible mutant-selective EGFR inhibitors that are wild-type sparing

Genetic modifications designed for xenotransplantation attenuate sialoadhesin‐dependent binding of human erythrocytes to porcine macrophages

Abstract 1048: Modulation of lipid metabolism through inhibition of acetyl-CoA carboxylase with ND-646 leads to potent inhibition of breast cancer cell growth in vitro and in vivo

A Methionine Aminopeptidase-2 Inhibitor, PPI-2458, for the Treatment of Rheumatoid Arthritis

αvβ3 Integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice

Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis

Methionine aminopeptidases type I and type II are essential to control cell proliferation

Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1

Liver Selective Acetyl-CoA Carboxylase Inhibition Inhibits Hepatocellular Carcinoma in a Cirrhosis Model

Leukocyte Adhesion to Vascular Endothelium Induces E-Selectin Linkage to the Actin Cytoskeleton

Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists

TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis

Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists

Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC

Suchergebnisse filtern