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Design, synthesis, and STING-agonistic activity of benzo[b]thiophene-2-carboxamide derivatives

Molecular diversity, 2023-10

2023

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Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors

Journal of medicinal chemistry, 2018-10, Vol.61 (20), p.9085-9104

2018

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Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.6289-6304

2017

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Microwave assisted solvent-free CH amination by silica-supported manganese dioxide

Tetrahedron letters, 2016-06, Vol.57 (22), p.2390-2394

2016

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A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease

Molecules (Basel, Switzerland), 2024-04, Vol.29 (8), p.1803

2024

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Catalytic Enantioselective Henry Reactions of Isatins: Application in the Concise Synthesis of (S)-(−)-Spirobrassinin

Chemistry : a European journal, 2011-07, Vol.17 (28), p.7791-7795

2011

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Organocatalytic Enantioselective Conjugate Additions to Enones

Journal of the American Chemical Society, 2006-10, Vol.128 (39), p.12652-12653

2006

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Synthesis of Chiral 3-Substituted Phthalides by a Sequential Organocatalytic Enantioselective Aldol-Lactonization Reaction. Three-Step Synthesis of (S)-(−)-3-Butylphthalide

Journal of organic chemistry, 2010-01, Vol.75 (2), p.368-374

2010

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Organocatalytic Asymmetric Michael Addition of 2,4-Pentandione to Nitroolefins

Organic letters, 2005-10, Vol.7 (21), p.4713-4716

2005

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A Novel Bifunctional Sulfonamide Primary Amine‐Catalyzed Enantioselective Conjugate Addition of Ketones to Nitroolefins

Advanced synthesis & catalysis, 2008-10, Vol.350 (14‐15), p.2194-2198

2008

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Highly enantioselective conjugate addition of nitroalkanes to enones catalyzed by cinchona alkaloid derived primary amine

Tetrahedron letters, 2013-07, Vol.54 (29), p.3791-3793

2013

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An efficient method for demethylation of aryl methyl ethers

Tetrahedron letters, 2008-06, Vol.49 (25), p.4054-4056

2008

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Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

Organic letters, 2009-07, Vol.11 (13), p.2864-2867

2009

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The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma

BMC cancer, 2009-09, Vol.9 (1), p.343-343, Article 343

2009

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Synthesis of triazolotriazine derivatives as c-Met inhibitors

Molecular diversity, 2021-05, Vol.25 (2), p.839-846

2021

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Enatioselective organocatalytic synthesis of highly functionalized tetrahydrothiophenes by a Michael-aldol cascade reaction

Tetrahedron letters, 2009-06, Vol.50 (24), p.2946-2948

2009

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Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by shikonin was partly through the inactivation of NF-κB pathway

Phytotherapy research, 2008-03, Vol.22 (3), p.407-415

2008

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Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation

Cell discovery, 2022-12, Vol.8 (1), p.133-133, Article 133

2022

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Gambogic acid inhibits the catalytic activity of human topoisomerase IIα by binding to its ATPase domain

Molecular cancer therapeutics, 2007-09, Vol.6 (9), p.2429-2440

2007

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Synthesis and Bioevaluation of Shikonin Derivatives

Letters in drug design & discovery, 2018-01, Vol.15 (9), p.945-950

2018

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A novel strategy for treating oncogene‐mutated tumors by targeting tumor microenvironment and synergistically enhancing anti‐PD‐1 immunotherapy

Cancer communications (London, England), 2024-03, Vol.44 (3), p.438-442

2024

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Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma

Acta pharmaceutica Sinica. B, 2023-12, Vol.13 (12), p.4748-4764

2023

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SH‐7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor

International journal of cancer, 2006-09, Vol.119 (5), p.1184-1193

2006

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Synthesis and biological activity of novel shikonin analogues

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.735-737

2009

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Synthesis and antitumor activity of 10-arylcamptothecin derivatives

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (7), p.2071-2074

2011

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Design, synthesis, and STING-agonistic activity of benzo[b]thiophene-2-carboxamide derivatives

Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors

Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization

Microwave assisted solvent-free CH amination by silica-supported manganese dioxide

A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease

Catalytic Enantioselective Henry Reactions of Isatins: Application in the Concise Synthesis of (S)-(−)-Spirobrassinin

Organocatalytic Enantioselective Conjugate Additions to Enones

Synthesis of Chiral 3-Substituted Phthalides by a Sequential Organocatalytic Enantioselective Aldol-Lactonization Reaction. Three-Step Synthesis of (S)-(−)-3-Butylphthalide

Organocatalytic Asymmetric Michael Addition of 2,4-Pentandione to Nitroolefins

A Novel Bifunctional Sulfonamide Primary Amine‐Catalyzed Enantioselective Conjugate Addition of Ketones to Nitroolefins

Highly enantioselective conjugate addition of nitroalkanes to enones catalyzed by cinchona alkaloid derived primary amine

An efficient method for demethylation of aryl methyl ethers

Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma

Synthesis of triazolotriazine derivatives as c-Met inhibitors

Enatioselective organocatalytic synthesis of highly functionalized tetrahydrothiophenes by a Michael-aldol cascade reaction

Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by shikonin was partly through the inactivation of NF-κB pathway

Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation

Gambogic acid inhibits the catalytic activity of human topoisomerase IIα by binding to its ATPase domain

Synthesis and Bioevaluation of Shikonin Derivatives

A novel strategy for treating oncogene‐mutated tumors by targeting tumor microenvironment and synergistically enhancing anti‐PD‐1 immunotherapy

Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma

SH‐7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor

Synthesis and biological activity of novel shikonin analogues

Synthesis and antitumor activity of 10-arylcamptothecin derivatives

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