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Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Nucleic acids research, 2011-11, Vol.39 (21), p.e142-e142

2011

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Tuberculosis and lung damage: from epidemiology to pathophysiology

European respiratory review, 2018-03, Vol.27 (147), p.170077

2018

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An ionizable lipid toolbox for RNA delivery

Nature communications, 2021-12, Vol.12 (1), p.7233-7233, Article 7233

2021

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Nanomaterial Delivery Systems for mRNA Vaccines

Vaccines (Basel), 2021-01, Vol.9 (1), p.65

2021

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Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

Nano letters, 2021-07, Vol.21 (13), p.5671-5680

2021

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Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Journal of controlled release, 2015-11, Vol.217, p.345-351

2015

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Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

Immunity (Cambridge, Mass.), 2005-08, Vol.23 (2), p.165-175

2005

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In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Nature biotechnology, 2021-08, Vol.39 (8), p.949-957

2021

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D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization

Cell host & microbe, 2021-01, Vol.29 (1), p.23-31.e4

2021

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Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice

Science (American Association for the Advancement of Science), 2021-08, Vol.373 (6558), p.991-998

2021

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Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis

Nature communications, 2023-01, Vol.14 (1), p.75-12, Article 75

2023

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The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity

Journal of the American Chemical Society, 2022-03, Vol.144 (11), p.4746-4753

2022

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Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA

Nature communications, 2021-01, Vol.12 (1), p.613-10, Article 613

2021

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Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

Nature communications, 2018-08, Vol.9 (1), p.3361-12, Article 3361

2018

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Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

Nature communications, 2017-03, Vol.8 (1), p.14630-8, Article 14630

2017

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PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake

Journal of controlled release, 2018-12, Vol.291, p.106-115

2018

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mRNA transcript therapy

Expert review of vaccines, 2015-02, Vol.14 (2), p.265-281

Weissman, Drew

2015

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Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

Communications biology, 2021-08, Vol.4 (1), p.956-956, Article 956

2021

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Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)

Journal of controlled release, 2022-04, Vol.344, p.50-61

2022

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Nucleoside-Modified mRNA Vaccines Protect IFNAR -/- Mice against Crimean-Congo Hemorrhagic Fever Virus Infection

Journal of virology, 2022-02, Vol.96 (3), p.e0156821

2022

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mRNA Is an Endogenous Ligand for Toll-like Receptor 3

The Journal of biological chemistry, 2004-03, Vol.279 (13), p.12542-12550

2004

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An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection

PLoS pathogens, 2020-07, Vol.16 (7), p.e1008795-e1008795

2020

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DELAYED INTRASPINAL DELIVERY OF MRNAS ENCODING A COMBINATION OF CYTOKINES AND GDNF PROMOTES MORPHOLOGICAL AND FUNCTIONAL RECOVERY FOLLOWING SPINAL CORD INJURY

IBRO neuroscience reports, 2023-10, Vol.15, p.S177-S177

2023

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Small Interfering RNAs Mediate Sequence-Independent Gene Suppression and Induce Immune Activation by Signaling through Toll-Like Receptor 3

The Journal of immunology (1950), 2004-06, Vol.172 (11), p.6545-6549

2004

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Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Tuberculosis and lung damage: from epidemiology to pathophysiology

An ionizable lipid toolbox for RNA delivery

Nanomaterial Delivery Systems for mRNA Vaccines

Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice

Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis

The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity

Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake

mRNA transcript therapy

Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)

Nucleoside-Modified mRNA Vaccines Protect IFNAR -/- Mice against Crimean-Congo Hemorrhagic Fever Virus Infection

mRNA Is an Endogenous Ligand for Toll-like Receptor 3

An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection

DELAYED INTRASPINAL DELIVERY OF MRNAS ENCODING A COMBINATION OF CYTOKINES AND GDNF PROMOTES MORPHOLOGICAL AND FUNCTIONAL RECOVERY FOLLOWING SPINAL CORD INJURY

Small Interfering RNAs Mediate Sequence-Independent Gene Suppression and Induce Immune Activation by Signaling through Toll-Like Receptor 3

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