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Evaluation of the Potential for Cytochrome P450 and Transporter-Mediated Drug-Drug Interactions for Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor (FXR) Agonist

Clinical pharmacokinetics, 2023-04, Vol.62 (4), p.609-621

2023

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Pharmacokinetics, pharmacodynamics, safety and tolerability of cilofexor, a novel nonsteroidal Farnesoid X receptor agonist, in healthy volunteers

Clinical and translational science, 2023-03, Vol.16 (3), p.536-547

2023

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Effect of Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist

Journal of clinical pharmacology, 2023-09, Vol.63 (9), p.1017-1025

2023

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A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury

Critical care medicine, 2011-07, Vol.39 (7), p.1655-1662

2011

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The association between platelet transfusion and idiopathic pneumonia syndrome is unaffected by platelet product type

Transfusion (Philadelphia, Pa.), 2016-02, Vol.56 (2), p.489-496

2016

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Anemia in Critical Illness: Insights into Etiology, Consequences, and Management

American journal of respiratory and critical care medicine, 2012-05, Vol.185 (10), p.1049-1057

2012

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An International Normalized Ratio–Based Definition of Acute Traumatic Coagulopathy Is Associated With Mortality, Venous Thromboembolism, and Multiple Organ Failure After Injury

Critical care medicine, 2015-07, Vol.43 (7), p.1429-1438

2015

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Cost-effectiveness of Implementing Low-Tidal Volume Ventilation in Patients With Acute Lung Injury

Chest, 2009-07, Vol.136 (1), p.79-88

2009

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Variation in the Incidence and Timing of Acute Lung Injury

Chest, 2013-04, Vol.143 (4), p.881-882

2013

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Effect of Renal Impairment on the Pharmacokinetics of Firsocostat, an Acetyl‐Coenzyme A Carboxylase Inhibitor, and Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist

Journal of clinical pharmacology, 2023-05, Vol.63 (5), p.560-568

2023

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Evaluation of the Potential for Cytochrome P450 and Transporter-Mediated Drug-Drug Interactions for Firsocostat, a Liver-Targeted Inhibitor of Acetyl-CoA Carboxylase

Clinical pharmacokinetics, 2024-09

2024

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Pharmacokinetics and Safety of Firsocostat, an Acetyl‐Coenzyme A Carboxylase Inhibitor, in Participants with Mild, Moderate, and Severe Hepatic Impairment

Journal of clinical pharmacology, 2024-07, Vol.64 (7), p.878-886

2024

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Pharmacokinetics and Safety of Cilofexor and Firsocostat in Healthy Japanese and Non-Japanese Participants

Journal of clinical pharmacology, 2024-08

2024

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Early Identification of Patients at Risk of Acute Lung Injury: Evaluation of Lung Injury Prediction Score in a Multicenter Cohort Study

American journal of respiratory and critical care medicine, 2011-02, Vol.183 (4), p.462-470

2011

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Assessment of Drug Resistance during Phase 2b Clinical Trials of Presatovir in Adults Naturally Infected with Respiratory Syncytial Virus

Antimicrobial agents and chemotherapy, 2020-08, Vol.64 (9)

2020

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Derivation and validation of a noninvasive prediction tool to identify pulmonary hypertension in patients with IPF: Evolution of the model FORD

The Journal of heart and lung transplantation, 2024-04, Vol.43 (4), p.547-553

2024

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The monocyte and acute respiratory distress syndrome: implicated, innocent bystander, or awash in research translation?

American journal of respiratory and critical care medicine, 2013-08, Vol.188 (4), p.407-408

Watkins, Timothy R

2013

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Effects of filgotinib on semen parameters and sex hormones in male patients with inflammatory diseases: results from the phase 2, randomised, double-blind, placebo-controlled MANTA and MANTA-RAy studies

Annals of the rheumatic diseases, 2023-08, Vol.82 (8), p.1049-1058

2023

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A randomized controlled trial of presatovir for respiratory syncytial virus after lung transplant

The Journal of heart and lung transplantation, 2023-07, Vol.42 (7), p.908-916

2023

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Prediction of critical illness during out-of-hospital emergency care

JAMA : the journal of the American Medical Association, 2010-08, Vol.304 (7), p.747

2010

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MANTA and MANTA-RAy: Rationale and Design of Trials Evaluating Effects of Filgotinib on Semen Parameters in Patients with Inflammatory Diseases

Advances in therapy, 2022-07, Vol.39 (7), p.3403-3422

2022

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Walking Acute Respiratory Distress Syndrome: A Target for Treatment and Prevention?

Critical care medicine, 2013-08, Vol.41 (8), p.2046-2047

Watkins, Timothy R

2013

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Evaluation of the Potential for Cytochrome P450 and Transporter-Mediated Drug-Drug Interactions for Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor (FXR) Agonist

A Phase 2, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients

Pharmacokinetics, pharmacodynamics, safety and tolerability of cilofexor, a novel nonsteroidal Farnesoid X receptor agonist, in healthy volunteers

Effect of Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist

A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury

The association between platelet transfusion and idiopathic pneumonia syndrome is unaffected by platelet product type

Anemia in Critical Illness: Insights into Etiology, Consequences, and Management

An International Normalized Ratio–Based Definition of Acute Traumatic Coagulopathy Is Associated With Mortality, Venous Thromboembolism, and Multiple Organ Failure After Injury

Cost-effectiveness of Implementing Low-Tidal Volume Ventilation in Patients With Acute Lung Injury

Variation in the Incidence and Timing of Acute Lung Injury

Effect of Renal Impairment on the Pharmacokinetics of Firsocostat, an Acetyl‐Coenzyme A Carboxylase Inhibitor, and Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist

Evaluation of the Potential for Cytochrome P450 and Transporter-Mediated Drug-Drug Interactions for Firsocostat, a Liver-Targeted Inhibitor of Acetyl-CoA Carboxylase

A Phase 2b, Randomized, Double-blind, Placebo-Controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of Presatovir in Hematopoietic Cell Transplant Recipients with Respiratory Syncytial Virus Infection of the Lower Respiratory Tract

Pharmacokinetics and Safety of Firsocostat, an Acetyl‐Coenzyme A Carboxylase Inhibitor, in Participants with Mild, Moderate, and Severe Hepatic Impairment

Pharmacokinetics and Safety of Cilofexor and Firsocostat in Healthy Japanese and Non-Japanese Participants

Early Identification of Patients at Risk of Acute Lung Injury: Evaluation of Lung Injury Prediction Score in a Multicenter Cohort Study

Assessment of Drug Resistance during Phase 2b Clinical Trials of Presatovir in Adults Naturally Infected with Respiratory Syncytial Virus

Derivation and validation of a noninvasive prediction tool to identify pulmonary hypertension in patients with IPF: Evolution of the model FORD

The monocyte and acute respiratory distress syndrome: implicated, innocent bystander, or awash in research translation?

Effects of filgotinib on semen parameters and sex hormones in male patients with inflammatory diseases: results from the phase 2, randomised, double-blind, placebo-controlled MANTA and MANTA-RAy studies

A randomized controlled trial of presatovir for respiratory syncytial virus after lung transplant

Prediction of critical illness during out-of-hospital emergency care

MANTA and MANTA-RAy: Rationale and Design of Trials Evaluating Effects of Filgotinib on Semen Parameters in Patients with Inflammatory Diseases

Walking Acute Respiratory Distress Syndrome: A Target for Treatment and Prevention?

AI-based automation of enrollment criteria and endpoint assessment in clinical trials in liver diseases

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