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Understanding Idiosyncratic Toxicity: Lessons Learned from Drug-Induced Liver Injury

Journal of medicinal chemistry, 2020-06, Vol.63 (12), p.6436-6461

2020

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The transformation in biomarker detection and management of drug‐induced liver injury

Liver international, 2017-11, Vol.37 (11), p.1582-1590

2017

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Incidence and Etiology of Drug-Induced Liver Injury in Mainland China

Gastroenterology (New York, N.Y. 1943), 2019-06, Vol.156 (8), p.2230-2241.e11

2019

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Hepatic histological findings in suspected drug‐induced liver injury: Systematic evaluation and clinical associations

Hepatology (Baltimore, Md.), 2014-02, Vol.59 (2), p.661-670

2014

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Polygenic architecture informs potential vulnerability to drug-induced liver injury

Nature medicine, 2020-10, Vol.26 (10), p.1541-1548

2020

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Candidate biomarkers for the diagnosis and prognosis of drug‐induced liver injury: An international collaborative effort

Hepatology (Baltimore, Md.), 2019-02, Vol.69 (2), p.760-773

2019

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Drug-induced liver injury : Summary of a single topic clinical research conference

Hepatology (Baltimore, Md.), 2006-03, Vol.43 (3), p.618-631

2006

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Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis

PloS one, 2019-01, Vol.14 (1), p.e0208958-e0208958

2019

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In silico modeling to optimize interpretation of liver safety biomarkers in clinical trials

Experimental biology and medicine (Maywood, N.J.), 2018-02, Vol.243 (3), p.300-307

2018

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Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

Gastroenterology (New York, N.Y. 1943), 2011-07, Vol.141 (1), p.338-347

2011

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Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group

PloS one, 2018-10, Vol.13 (10), p.e0206389-e0206389

2018

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Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.916-932

2018

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Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences

PloS one, 2022-12, Vol.17 (12), p.e0278297-e0278297

2022

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Assessing Liver Effects of Cannabidiol and Valproate Alone and in Combination Using Quantitative Systems Toxicology

Clinical pharmacology and therapeutics, 2023-11, Vol.114 (5), p.1006-1014

2023

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Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

Nature reviews. Drug discovery, 2007-11, Vol.6 (11), p.904-916

2007

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Precision Dosing Priority Criteria: Drug, Disease, and Patient Population Variables

Frontiers in pharmacology, 2020-04, Vol.11, p.420

2020

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Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

Toxicological sciences, 2017-01, Vol.155 (1), p.61-74

2017

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Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury

Toxicological sciences, 2019-08, Vol.170 (2), p.499-508

2019

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Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse

PloS one, 2020-10, Vol.15 (10), p.e0240562

2020

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Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injury

Hepatology (Baltimore, Md.), 2008-10, Vol.48 (4), p.1175-1183

2008

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Liver Injury Due to Drugs and Viruses: Mechanistic Similarities and Implications for AAV Gene Therapy

Clinical pharmacology and therapeutics, 2022-10, Vol.112 (4), p.751-753

Watkins, Paul B.

2022

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Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization

Toxicological sciences, 2019-10, Vol.171 (2), p.431-442

2019

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Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

Liver international, 2014-03, Vol.34 (3), p.367-378

2014

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The Challenge of Interpreting Alanine Aminotransferase Elevations in Clinical Trials of New Drug Candidates

Clinical and translational science, 2021-03, Vol.14 (2), p.434-436

2021

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Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

Journal of pharmaceutical sciences, 2016-02, Vol.105 (2), p.443-459

2016

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Understanding Idiosyncratic Toxicity: Lessons Learned from Drug-Induced Liver Injury

The transformation in biomarker detection and management of drug‐induced liver injury

Incidence and Etiology of Drug-Induced Liver Injury in Mainland China

Hepatic histological findings in suspected drug‐induced liver injury: Systematic evaluation and clinical associations

Polygenic architecture informs potential vulnerability to drug-induced liver injury

Candidate biomarkers for the diagnosis and prognosis of drug‐induced liver injury: An international collaborative effort

Drug-induced liver injury : Summary of a single topic clinical research conference

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis

In silico modeling to optimize interpretation of liver safety biomarkers in clinical trials

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group

Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences

Assessing Liver Effects of Cannabidiol and Valproate Alone and in Combination Using Quantitative Systems Toxicology

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

Precision Dosing Priority Criteria: Drug, Disease, and Patient Population Variables

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury

Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse

Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injury

Liver Injury Due to Drugs and Viruses: Mechanistic Similarities and Implications for AAV Gene Therapy

Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization

Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

The Challenge of Interpreting Alanine Aminotransferase Elevations in Clinical Trials of New Drug Candidates

Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

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